Carbonic Acid (CID 767) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(1)
 
 
Inconclusive(1)
 
 
Unspecified(39)
 
 
Top Targets:
alpha CA I II..(10)
 
 
alpha CA IV X..(4)
 
 
 
alpha CA(2)
 
 
 
LbH gamma CA(1)
 
 
alpha CA V(1)
 
 
BioAssay Types:
Literature(40)
 
 
 
 
BioActivity Types:
Ki(25)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 41    Data Row: 41   Total Pages: 1   
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103761718]
Ki 8.6Inhibitory activity against human Carbonic anhydrase IX [AID238442, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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2
[SID103761718]
Ki 270Inhibition of human recombinant CA7 [AID265737, Type: Literature]Carbonic anhydrase 7 [gi:1168744]
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3
[SID103761718]
Ki 450Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay [AID552130, Type: Literature]
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4
[SID103761718]
Ki 800Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay [AID552129, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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5
[SID103761718]
Ki 5700Inhibitory activity against human Carbonic anhydrase IV [AID238441, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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6
[SID103761718]
Ki 6600Inhibition constant of anion against human carbonic anhydrase isozyme hCA IV [AID238544, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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7
[SID103761718]
Ki 7810Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay [AID552131, Type: Literature]
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8
[SID103761718]
Ki 12000Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay [AID552127, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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9
[SID103761718]
Ki 12000Inhibitory activity against human carbonic anhydrase I expressed in Escherichia coli [AID238687, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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10
[SID103761718]
Ki 12000Inhibition constant of anion against human carbonic anhydrase isozyme hCA I [AID238513, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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11
[SID103761718]
Ki 12000Inhibitory constant against carbonic anhydrase I [AID238317, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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12
[SID103761718]
Ki 13000Inhibition constant of anion against human carbonic anhydrase isozyme hCA IX [AID238546, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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13
[SID103761718]
Ki 15000Inhibitory activity against human Carbonic anhydrase I [AID238410, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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14
[SID103761718]
Ki 42000Inhibitory constant against Zn-Cam (Methanosarcina thermophila) [AID238607, Type: Literature]Carbonic anhydrase [gi:729004]
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15
[SID103761718]
Ki 44000Inhibitory constant against carbonic anhydrase IV [AID238328, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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16
[SID103761718]
Ki 44900Inhibitory constant against methanoarchaeon Methanobacterium thermoautotrophicum (Cab) [AID238958, Type: Literature]
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17
[SID103761718]
Ki 73000Inhibitory activity against human Carbonic anhydrase II [AID238440, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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18
[SID103761718]
Ki 82000Inhibition constant of anion against human carbonic anhydrase isozyme hCA V [AID238515, Type: Literature]
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19
[SID103761718]
Ki 82000Inhibitory activity against human carbonic anhydrase V expressed in Escherichia coli [AID238688, Type: Literature]
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20
[SID103761718]
Ki 85000Inhibitory constant against carbonic anhydrase II [AID238327, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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21
[SID103761718]
Ki 85000Inhibition constant of anion against human carbonic anhydrase isozyme hCA II [AID238542, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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22
[SID103761718]
Ki 85000Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli [AID238715, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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23
[SID103761718]
Ki 85000Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay [AID552128, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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24
[SID103761718]
Ki 95000Inhibitory activity against human Carbonic anhydrase V [AID238411, Type: Literature]Carbonic anhydrase 5A, mitochondrial [gi:461680]
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25
[SID103761718]
Ki 140000Inhibitory activity against mouse carbonic anhydrase XIII expressed in Escherichia coli TOP 10 [AID238853, Type: Literature]
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26
[SID103761718]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia [AID625279, Type: Literature]
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27
[SID103761718]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis [AID625280, Type: Literature]
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28
[SID103761718]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis [AID625281, Type: Literature]
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29
[SID103761718]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis [AID625282, Type: Literature]
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30
[SID103761718]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests [AID625283, Type: Literature]
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31
[SID103761718]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure [AID625284, Type: Literature]
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32
[SID103761718]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis [AID625285, Type: Literature]
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33
[SID103761718]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis [AID625286, Type: Literature]
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34
[SID103761718]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly [AID625287, Type: Literature]
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35
[SID103761718]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice [AID625288, Type: Literature]
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36
[SID103761718]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease [AID625289, Type: Literature]
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37
[SID103761718]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty [AID625290, Type: Literature]
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38
[SID103761718]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal [AID625291, Type: Literature]
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39
[SID103761718]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score [AID625292, Type: Literature]
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40
[SID103761718]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681140, Type: other]
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41
[SID103761718]
 Inhibitory constant against carbonic anhydrase IV ; nt= not tested [AID238653, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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