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CHEMBL234838 (CID 766948) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(9)
 
 
Inconclusive(1)
 
 
Unspecified(458)
 
 
Top Targets:
PTKc Abl(16)
 
 
PTKc EGFR(10)
 
 
PKc like(10)
 
 
STKc MARK(8)
 
 
PTKc PDGFR al..(8)
 
 
BioAssay Types:
Literature(9)
 
 
 
 
Confirmatory(5)
 
 
 
 
BioActivity Types:
Potency(7)
 
 
 
 
IC50(3)
 
 
 
AC50(2)
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 473    Data Row: 474   Total Pages: 24   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103534542]
IC50 0.39811Inhibition of human truncated JNK3 [AID298743, Type: Literature]Mitogen-activated protein kinase 10 [gi:2507196]
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2
[SID53812801]
Ki 0.4Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Crystal Structure Of Human Jnk3 Complexed With N-(3-Cyano-4,5,6,7- Tetrahydro-1-Benzothien-2-Yl)-2-Fluorobenzamide [gi:134105039]
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3
[SID53812801]
Ki 0.4Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Crystal Structure Of Human Jnk3 Complexed With N-(3-Cyano-4,5,6,7- Tetrahydro-1-Benzothien-2-Yl)-2-Fluorobenzamide [gi:134105039]
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4
[SID124349907]
Potency 0.8191qHTS Assay for Inhibitors of Firefly Luciferase from the GSK Published Protein Kinase Inhibitor Set [AID652016, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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5
[SID53812801]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Human Jnk3 Complexed With N-(3-Cyano-4,5,6,7- Tetrahydro-1-Benzothien-2-Yl)-2-Fluorobenzamide [gi:134105039]
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6
[SID134352647]
A screen for small compounds that change glucocorticoid sensitivity in NFkB suppression [AID624486, Type: other]
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7
[SID103534542]
AC50 0.8191GSK_PKIS: Inhibition of Firefly Luciferase (Data from PubChem: AID 652016) [NIH NCATS] [AID720835, Type: Literature]Luciferin 4-monooxygenase [gi:126501]
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8
[SID103534542]
IC50 10Inhibition of human recombinant full length JNK1alpha1 [AID298742, Type: Literature]Mitogen-activated protein kinase 8 [gi:2507195]
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9
[SID103534542]
IC50 15.8489Inhibition of mitogen-activated protein kinase p38alpha [AID298744, Type: Literature]
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10
[SID103534542]
GSK_PKIS: PIP5K1 (Caliper assay) % inhibition at 5 uM [UNC Frye lab] [AID651545, Type: other]
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11
[SID103534542]
AC50 GSK_PKIS: Inhibition of Sea Pansy Luciferase (Data from PubChem: AID 652015) [NIH NCATS] [AID720834, Type: Literature]Renilla-luciferin 2-monooxygenase [gi:126502]
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12
[SID103534542]
GSK_PKIS: PDGFRB mean inhibition at 0.1 uM [Nanosyn] [AID651298, Type: other]Platelet-derived growth factor receptor beta [gi:129890]
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13
[SID103534542]
GSK_PKIS: PDGFRB mean inhibition at 1 uM [Nanosyn] [AID651299, Type: other]Platelet-derived growth factor receptor beta [gi:129890]
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14
[SID103534542]
GSK_PKIS: PDGFRA mean inhibition at 0.1 uM [Nanosyn] [AID651290, Type: other]Platelet-derived growth factor receptor alpha [gi:129892]
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15
[SID103534542]
GSK_PKIS: PDGFRA mean inhibition at 1 uM [Nanosyn] [AID651291, Type: other]Platelet-derived growth factor receptor alpha [gi:129892]
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16
[SID103534542]
GSK_PKIS: PDGFRA (D842V mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651292, Type: other]Platelet-derived growth factor receptor alpha [gi:129892]
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17
[SID103534542]
GSK_PKIS: PDGFRA (D842V mutant) mean inhibition at 1 uM [Nanosyn] [AID651293, Type: other]Platelet-derived growth factor receptor alpha [gi:129892]
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18
[SID103534542]
GSK_PKIS: PDGFRA (T674I mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651294, Type: other]Platelet-derived growth factor receptor alpha [gi:129892]
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19
[SID103534542]
GSK_PKIS: PDGFRA (T674I mutant) mean inhibition at 1 uM [Nanosyn] [AID651295, Type: other]Platelet-derived growth factor receptor alpha [gi:129892]
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20
[SID103534542]
GSK_PKIS: PDGFRA (V561D mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651296, Type: other]Platelet-derived growth factor receptor alpha [gi:129892]
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