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CHEMBL234838 (CID 766948) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(9)
 
 
Inconclusive(1)
 
 
Unspecified(458)
 
 
Top Targets:
PKc like(42)
 
 
PKc(42)
 
 
STKc AGC(16)
 
 
PTKc Abl(16)
 
 
PTKc Src like(11)
 
 
 
BioAssay Types:
Literature(9)
 
 
 
 
Confirmatory(5)
 
 
 
 
BioActivity Types:
Potency(7)
 
 
 
 
IC50(3)
 
 
 
AC50(2)
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 473    Data Row: 474   Total Pages: 24   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103534542]
IC50 0.39811Inhibition of human truncated JNK3 [AID298743, Type: Literature]Mitogen-activated protein kinase 10 [gi:2507196]
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2
[SID53812801]
Ki 0.4Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Crystal Structure Of Human Jnk3 Complexed With N-(3-Cyano-4,5,6,7- Tetrahydro-1-Benzothien-2-Yl)-2-Fluorobenzamide [gi:134105039]
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3
[SID53812801]
Ki 0.4Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Crystal Structure Of Human Jnk3 Complexed With N-(3-Cyano-4,5,6,7- Tetrahydro-1-Benzothien-2-Yl)-2-Fluorobenzamide [gi:134105039]
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4
[SID124349907]
Potency 0.8191qHTS Assay for Inhibitors of Firefly Luciferase from the GSK Published Protein Kinase Inhibitor Set [AID652016, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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5
[SID53812801]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Human Jnk3 Complexed With N-(3-Cyano-4,5,6,7- Tetrahydro-1-Benzothien-2-Yl)-2-Fluorobenzamide [gi:134105039]
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6
[SID134352647]
A screen for small compounds that change glucocorticoid sensitivity in NFkB suppression [AID624486, Type: other]
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7
[SID103534542]
AC50 0.8191GSK_PKIS: Inhibition of Firefly Luciferase (Data from PubChem: AID 652016) [NIH NCATS] [AID720835, Type: Literature]Luciferin 4-monooxygenase [gi:126501]
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8
[SID103534542]
IC50 10Inhibition of human recombinant full length JNK1alpha1 [AID298742, Type: Literature]Mitogen-activated protein kinase 8 [gi:2507195]
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9
[SID103534542]
IC50 15.8489Inhibition of mitogen-activated protein kinase p38alpha [AID298744, Type: Literature]
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10
[SID103534542]
GSK_PKIS: PIP5K1 (Caliper assay) % inhibition at 5 uM [UNC Frye lab] [AID651545, Type: other]
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11
[SID103534542]
GSK_PKIS: ALK mean inhibition at 0.1 uM [Nanosyn] [AID651384, Type: other]ALK tyrosine kinase receptor [gi:296439447]
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12
[SID103534542]
GSK_PKIS: ALK mean inhibition at 1 uM [Nanosyn] [AID651385, Type: other]ALK tyrosine kinase receptor [gi:296439447]
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13
[SID103534542]
GSK_PKIS: BRK mean inhibition at 0.1 uM [Nanosyn] [AID651394, Type: other]Protein-tyrosine kinase 6 [gi:8928302]
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14
[SID103534542]
GSK_PKIS: BRK mean inhibition at 1 uM [Nanosyn] [AID651395, Type: other]Protein-tyrosine kinase 6 [gi:8928302]
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15
[SID103534542]
GSK_PKIS: CK1a mean inhibition at 0.1 uM [Nanosyn] [AID651154, Type: other]Casein kinase I isoform alpha [gi:31077177]
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16
[SID103534542]
GSK_PKIS: CK1a mean inhibition at 1 uM [Nanosyn] [AID651155, Type: other]Casein kinase I isoform alpha [gi:31077177]
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17
[SID103534542]
GSK_PKIS: YES mean inhibition at 0.1 uM [Nanosyn] [AID651450, Type: other]Tyrosine-protein kinase Yes [gi:125870]
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18
[SID103534542]
GSK_PKIS: YES mean inhibition at 1 uM [Nanosyn] [AID651451, Type: other]Tyrosine-protein kinase Yes [gi:125870]
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19
[SID103534542]
GSK_PKIS: MARK4 mean inhibition at 0.1 uM [Nanosyn] [AID651120, Type: other]MAP/microtubule affinity-regulating kinase 4 [gi:29840797]
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20
[SID103534542]
GSK_PKIS: MARK4 mean inhibition at 1 uM [Nanosyn] [AID651121, Type: other]MAP/microtubule affinity-regulating kinase 4 [gi:29840797]
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