1-[2-(4-Chloro-phenoxy)-ethyl]-1H-benzoimidazol-2-ylamine (CID 761923) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(8)
 
 
Inactive(439)
 
 
Inconclusive(15)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
7TM GPCR Srsx(6)
 
 
CARD NOD1 CAR..(5)
 
 
 
TRP 2(5)
 
 
 
Pyruvate Kina..(4)
 
 
BioAssay Types:
Screening(315)
 
 
 
 
Confirmatory(141)
 
 
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(100)
 
 
 
 
IC50(35)
 
 
 
EC50(4)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 463    Data Row: 463   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85285636]
IC50 8.6SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2505, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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2
[SID85285636]
IC50 8.6SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2505, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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3
[SID85285636]
IC50 8.6SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2505, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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4
[SID85285636]
IC50 12.71SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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5
[SID85285636]
IC50 12.71SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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6
[SID47203483]
 Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID624268, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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7
[SID47203483]
 Luminescence-based biochemical high throughput confirmation assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID624412, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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8
[SID47203483]
 Fluorescent Polarization-based biochemical high throughput orthogonal assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID651607, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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9
[SID47203483]
 Primary cell-based screen for identification of compounds that inhibit transient receptor potential cation channel C4 (TRPC4). [AID2247, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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10
[SID47203483]
 Primary cell-based high-throughput screening for identification of compounds that allosterically activate MrgX1 receptor signaling [AID588675, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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11
[SID47203483]
 Primary cell-based high-throughput screening for identification of compounds that allosterically activate MrgX1 receptor signaling [AID588675, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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12
[SID47203483]
 Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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13
[SID47203483]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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14
[SID47203483]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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15
[SID85285636]
IC50 20SAR analysis of inhibitors of TNFa specific NF-kB induction revised [AID2337, Type: confirmatory]TNF gene product [Homo sapiens] [gi:25952111]
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16
[SID85285636]
IC50 20SAR analysis of inhibitors of TNFa specific NF-kB induction revised [AID2337, Type: confirmatory]TNF gene product [Homo sapiens] [gi:25952111]
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17
[SID85285636]
IC50 20SAR analysis of compounds that inhibit NOD2 revised [AID2334, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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18
[SID85285636]
IC50 20SAR analysis of compounds that inhibit NOD2 revised [AID2334, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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19
[SID85285636]
IC50 20SAR analysis of compounds that inhibit NOD2 revised [AID2334, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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20
[SID85285636]
IC50 20SAR analysis of compounds that are cytotoxic to HEK293 revised [AID2335, Type: confirmatory]
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21
[SID47203483]
Potency 22.3872qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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22
[SID85285636]
IC50 25SAR analysis of NF-kappaB dependent luciferase using Doxorucibin as an inducer - Set 2 [AID2789, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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23
[SID85285636]
IC50 25SAR analysis of NF-kappaB dependent luciferase using Doxorucibin as an inducer - Set 2 [AID2789, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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24
[SID85285636]
IC50 25SAR analysis of NF-kappaB dependent luciferase using PMA/Ionomycin as an inducer - 2 [AID2792, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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25
[SID85285636]
IC50 25SAR analysis of NF-kappaB dependent luciferase using PMA/Ionomycin as an inducer - 2 [AID2792, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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26
[SID85285636]
IC50 25SAR analysis of NF-kappaB dependent luciferase using DAP as an inducer - Set 2 [AID2793, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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27
[SID85285636]
IC50 25SAR analysis of NF-kappaB dependent luciferase using DAP as an inducer - Set 2 [AID2793, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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28
[SID85285636]
IC50 25SAR analysis of Muramyl dipeptide (MDP) induced IL-8 secretion in MCF-7/NOD2 cells - Set 2 [AID2503, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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29
[SID85285636]
IC50 25SAR analysis of Muramyl dipeptide (MDP) induced IL-8 secretion in MCF-7/NOD2 cells - Set 2 [AID2503, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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30
[SID85285636]
IC50 25SAR analysis of Muramyl dipeptide (MDP) induced IL-8 secretion in MCF-7/NOD2 cells - Set 2 [AID2503, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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31
[SID85285636]
IC50 25SAR analysis of Tumor necrosis factor alpha (TNF-alpha) induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2504, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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32
[SID85285636]
IC50 25SAR analysis of Tumor necrosis factor alpha (TNF-alpha) induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2504, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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33
[SID85285636]
IC50 25SAR analysis of Tumor necrosis factor alpha (TNF-alpha) induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2504, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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34
[SID47203483]
Potency 79.4328HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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35
[SID47203483]
Potency 89.1251qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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36
[SID47203483]
Potency 89.1251qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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37
[SID47203483]
 Activator for delta FosB/delta FosB homodimer Measured in Biochemical System Using Plate Reader - 2072-01_Activator_SinglePoint_HTS_Activity [AID493131, Type: screening]protein fosB [Mus musculus] [gi:6679827]
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38
[SID47203483]
 uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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39
[SID47203483]
 uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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40
[SID47203483]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). [AID2098, Type: screening]Hsf1 protein [Mus musculus] [gi:62740231]
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41
[SID47203483]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). [AID2098, Type: screening]Hsf1 protein [Mus musculus] [gi:62740231]
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42
[SID47203483]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) [AID624169, Type: screening]Htr2a gene product [Mus musculus] [gi:27753985]
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43
[SID47203483]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) [AID624169, Type: screening]Htr2a gene product [Mus musculus] [gi:27753985]
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44
[SID47203483]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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45
[SID47203483]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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46
[SID47203483]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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47
[SID47203483]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID1672, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
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48
[SID47203483]
IC50 Fluorescence for the identification of compounds that decrease p/CIP protein stability [AID1984, Type: confirmatory]nuclear receptor coactivator 3 [Mus musculus] [gi:118026946]
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49
[SID47203483]
 Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R1A (PKA-R1A) complex [AID504707, Type: screening]cAMP-dependent protein kinase catalytic subunit beta isoform 1 [Mus musculus] [gi:6755076]
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50
[SID47203483]
Potency qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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