ZINC05168882 (CID 7532476) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(17)
 
 
Inactive(581)
 
 
Inconclusive(10)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
 
Bcl-2 like(16)
 
 
 
alkPPc(10)
 
 
7TM GPCR Srsx(8)
 
 
G-alpha(6)
 
 
 
BioAssay Types:
Screening(407)
 
 
 
 
Confirmatory(187)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(122)
 
 
 
 
IC50(34)
 
 
EC50(24)
 
 
 
AC50(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 609    Data Row: 609   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24815803]
EC50 5.17Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL. [AID1322, Type: confirmatory]bcl-xL [Homo sapiens] [gi:510901]
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2
[SID24815803]
EC50 5.17Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL. [AID1322, Type: confirmatory]bcl-xL [Homo sapiens] [gi:510901]
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3
[SID24815803]
EC50 5.17Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL. [AID1322, Type: confirmatory]bcl-xL [Homo sapiens] [gi:510901]
View
4
[SID24815803]
EC50 5.76Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Mcl-1. [AID1329, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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5
[SID24815803]
EC50 5.76Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Mcl-1. [AID1329, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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6
[SID24815803]
EC50 5.76Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Mcl-1. [AID1329, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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7
[SID24815803]
EC50 7.843Profiling Assay to determine GST-GSH interactions in multiplex bead-based assays [AID1769, Type: confirmatory]glutathione S-transferase [Homo sapiens] [gi:31933]
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8
[SID24815803]
EC50 7.843Profiling Assay to determine GST-GSH interactions in multiplex bead-based assays [AID1769, Type: confirmatory]glutathione S-transferase [Homo sapiens] [gi:31933]
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9
[SID24815803]
EC50 7.89Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-W. [AID1330, Type: confirmatory]Bcl-w [Homo sapiens] [gi:1572493]
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10
[SID24815803]
EC50 7.89Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-W. [AID1330, Type: confirmatory]Bcl-w [Homo sapiens] [gi:1572493]
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11
[SID24815803]
AC50 16.56ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_Dose_CherryPick_Activity [AID651703, Type: confirmatory]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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12
[SID24815803]
AC50 16.56ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_Dose_CherryPick_Activity [AID651703, Type: confirmatory]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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13
[SID24815803]
 ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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14
[SID24815803]
 ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
View
15
[SID24815803]
 Primary biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase [AID1527, Type: screening]metallo beta-lactamase [Pseudomonas aeruginosa] [gi:7381449]
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16
[SID24815803]
 Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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17
[SID24815803]
 Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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18
[SID24815803]
 Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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19
[SID24815803]
 Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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20
[SID24815803]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID761, Type: screening]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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21
[SID24815803]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID759, Type: screening]ras protein [Homo sapiens] [gi:190938]
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22
[SID24815803]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID759, Type: screening]ras protein [Homo sapiens] [gi:190938]
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23
[SID24815803]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID759, Type: screening]ras protein [Homo sapiens] [gi:190938]
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24
[SID24815803]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID760, Type: screening]Ras-related protein Rab-2 [gi:46577642]
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25
[SID24815803]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype [AID757, Type: screening]Rac1 protein [Homo sapiens] [gi:8574038]
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26
[SID24815803]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype [AID757, Type: screening]Rac1 protein [Homo sapiens] [gi:8574038]
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27
[SID24815803]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant [AID764, Type: screening]Rac1 protein [Homo sapiens] [gi:8574038]
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28
[SID24815803]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant [AID764, Type: screening]Rac1 protein [Homo sapiens] [gi:8574038]
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29
[SID24815803]
 qHTS Assay for Inhibitors of the CtBP/E1A Interaction [AID651724, Type: screening]CtBP interacting protein CtIP [Homo sapiens] [gi:1730321]
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30
[SID24815803]
 Epi-absorbance-based confirmation assay for common VIM-2 and IMP-1 inhibitors: biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase. [AID2187, Type: screening]metallo beta-lactamase [Pseudomonas aeruginosa] [gi:7381449]
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31
[SID24815803]
 qHTS Assay for Inhibitors of the Six1/Eya2 Interaction [AID651725, Type: screening]six1 [Homo sapiens] [gi:1246761]
View
32
[SID24815803]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype [AID758, Type: screening]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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33
[SID24815803]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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34
[SID24815803]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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35
[SID24815803]
EC50 3.53Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B protein. [AID1327, Type: confirmatory]Bcl-2-like protein 10 [gi:23396469]
View
36
[SID24815803]
EC50 3.53Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B protein. [AID1327, Type: confirmatory]Bcl-2-like protein 10 [gi:23396469]
View
37
[SID24815803]
EC50 3.53Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B protein. [AID1327, Type: confirmatory]Bcl-2-like protein 10 [gi:23396469]
View
38
[SID24815803]
Potency 11.2202qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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39
[SID24815803]
Potency 11.2202qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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40
[SID24815803]
Potency qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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41
[SID24815803]
 Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL. [AID1007, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
View
42
[SID24815803]
 Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL. [AID1007, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
View
43
[SID24815803]
 Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL. [AID1007, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
View
44
[SID24815803]
EC50 Profiling Assay to determine GST-GSH interactions in multiplex bead-based assays (HPSMTB buffer) [AID1324, Type: confirmatory]glutathione S-transferase [Homo sapiens] [gi:31933]
View
45
[SID24815803]
EC50 Profiling Assay to determine GST-GSH interactions in multiplex bead-based assays (HPSMTB buffer) [AID1324, Type: confirmatory]glutathione S-transferase [Homo sapiens] [gi:31933]
View
46
[SID24815803]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID434989, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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47
[SID24815803]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID434989, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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48
[SID24815803]
 FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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49
[SID24815803]
 FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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50
[SID24815803]
 qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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