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benzylamine (CID 7504) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(12)
 
 
Inactive(129)
 
 
Inconclusive(8)
 
 
Unspecified(53)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
NR LBD ER(7)
 
 
NAD binding 8(7)
 
 
NR LBD AR(7)
 
 
 
NR LBD VDR(5)
 
 
BioAssay Types:
Confirmatory(87)
 
 
 
Literature(64)
 
 
 
 
Summary(24)
 
 
Screening(17)
 
 
BioActivity Types:
Potency(105)
 
 
 
Ki(8)
 
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 194    Data Row: 202   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103174520]
Km 6.7Michaelis-Menten constant for semicarbazide-sensitive amine oxidase (SSAO) from human, rat or mouse crude membranes [AID239765, Type: Literature]
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2
[SID103174520]
Km 15.4Binding affinity to mouse SSAO [AID273100, Type: Literature]Membrane primary amine oxidase [gi:5902787]
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3
[SID103174520]
Ki 20In vitro for binding affinity against Alpha-2 adrenergic receptor by radioligand [3H]clonidine in rat [AID37364, Type: Literature]Alpha-2A adrenergic receptor [gi:231461]
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4
[SID103174520]
Ki 20In vitro for binding affinity against Alpha-2 adrenergic receptor by radioligand [3H]clonidine in rat [AID37364, Type: Literature]Alpha-2C adrenergic receptor [gi:231464]
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5
[SID103174520]
Ki 20In vitro for binding affinity against Alpha-2 adrenergic receptor by radioligand [3H]clonidine in rat [AID37364, Type: Literature]Alpha-2B adrenergic receptor [gi:47117345]
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6
[SID103174520]
Ki 20Displacement of [3H]clonidine from adrenergic alpha-1 receptor in Sprague-Dawley rat cortex [AID313559, Type: Literature]
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7
[SID103174520]
Stimulation of glucose transport in mouse adipocytes at 0.1 mM in presence of sodium orthovanadate [AID273101, Type: Literature]
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8
[SID103174520]
Stimulation of glucose transport in mouse adipocytes at 1 mM in presence of sodium orthovanadate [AID273102, Type: Literature]
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9
[SID48415031]
DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity [AID1188, Type: other]
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10
[SID46393946]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Bovine Pancreas Beta-Trypsin In Complex With Benzylamine [gi:4699788]
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11
[SID46393333]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Trypsin Specificity As Elucidated By Lie Calculations, X-Ray Structures And Association Constant Measurements [gi:42543832]
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12
[SID46393336]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Trypsin Specificity As Elucidated By Lie Calculations, X-Ray Structures And Association Constant Measurements [gi:42543836]
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13
[SID103174520]
IC50 40Antiproliferative activity against human SKBR3 cells after 72 hrs [AID304707, Type: Literature]
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14
[SID103174520]
Km 124Km for Benzylamine oxidase of porcine serum [AID239730, Type: Literature]
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15
[SID103174520]
Km 168.83Kinetic constant (Km) determined in rat brain mitochondria [AID125407, Type: Literature]
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16
[SID103174520]
Ki 170Inhibition of bovine PNMT by radiochemical assay [AID313558, Type: Literature]Phenylethanolamine N-methyltransferase [gi:130374]
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17
[SID103174520]
Ki 179In vitro for inhibition of Phenylethanolamine N-Methyltransferase (PNMT) [AID155135, Type: Literature]Phenylethanolamine N-methyltransferase [gi:130374]
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18
[SID103174520]
Km 224Binding affinity to human SSAO [AID273099, Type: Literature]Membrane primary amine oxidase [gi:2501336]
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19
[SID103174520]
Km 249Activity at baboon liver mitochondrial MAO-B assessed as initial rate of H2O2 production after 8 mins [AID488098, Type: Literature]
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20
[SID103174520]
MIC 250Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by ten-fold serial dilution method [AID643449, Type: Literature]
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21
[SID103174520]
Km 290Michaelis Menten constant against MAO B. [AID102575, Type: Literature]Amine oxidase [flavin-containing] B [gi:124028638]
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22
[SID103174520]
Km 290Oxidation by bovine mono-amine oxidase B MAO-B [AID102891, Type: Literature]Amine oxidase [flavin-containing] B [gi:124028638]
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23
[SID103174520]
Km 557Km for Diamine oxidase of porcine kidney [AID239728, Type: Literature]
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24
[SID103174520]
Km 780Michaelis Menten constant against MAO A. [AID102566, Type: Literature]
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25
[SID103174520]
Ki 1063Displacement of [3H]MK801 from NMDA receptor in rat brain neuronal membrane [AID353103, Type: Literature]
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26
[SID103174520]
Ki 299916The compound was tested for inhibition of the proteolytic enzyme trypsin. [AID215915, Type: Literature]
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27
[SID103174520]
Inhibition of phenylethanolamine N-methyltransferase(PNMT)activity [AID225081, Type: Literature]
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28
[SID103174520]
Selectivity ratio between Ki of alpha-2 adrenoceptor and Ki of PNMT [AID229906, Type: Literature]
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29
[SID103174520]
Binding affinity to calf thymus DNA assessed as thermal stability in BPE buffer at 2 uM [AID304717, Type: Literature]
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30
[SID103174520]
Binding affinity to calf thymus dodecamer DNA assessed as thermal stability in cacodylate buffer at 12 uM [AID304718, Type: Literature]
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31
[SID103174520]
Binding affinity to calf thymus dodecamer DNA assessed as thermal stability in cacodylate buffer containing 0.1 M NaCl at 12 uM [AID304719, Type: Literature]
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32
[SID103174520]
Ratio of Kinetic constants (Km vs. Vmax). [AID125530, Type: Literature]
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33
[SID103174520]
Kinetic constant (Vmax) determined in rat brain mitochondria. [AID125532, Type: Literature]
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34
[SID103174520]
Percent inhibition of MAO-catalyzed oxidation in rat brain mitochondria induced by pargyline [AID125534, Type: Literature]
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35
[SID103174520]
Tested for pargyline-induced inhibition of MAO-catalyzed oxidation in rat brain mitochondria (Specific inhibitor = Pargyline hydrochloride at 2.5 uM) (Control = 16.68) [AID125535, Type: Literature]
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36
[SID103174520]
Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system [AID237685, Type: Literature]
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37
[SID103174520]
Vmax for Diamine oxidase of porcine kidney [AID242901, Type: Literature]
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38
[SID103174520]
Vmax for porcine serum Benzylamine oxidase [AID242903, Type: Literature]
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39
[SID103174520]
Maximum velocity for semicarbazide-sensitive amine oxidase (SSAO) of human, mouse or rat crude membranes [AID242909, Type: Literature]
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40
[SID103174520]
Ratio of Vmax/Km for human, mouse or rat SSAO [AID242942, Type: Literature]
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41
[SID103174520]
Inhibitory activity against bovine adrenal phenylethanolamine N-methyl-transferase (PNMT) [AID156064, Type: Literature]
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42
[SID103174520]
Turnover number against MAO A (umol of substrate/min per umol of enzyme). [AID102567, Type: Literature]
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43
[SID103174520]
Selectivity of guest-induced changes in membrane potential at pH 5.0 for PVC matrix liquid membrane without any host [AID18736, Type: Literature]
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44
[SID103174520]
Selectivity of guest-induced changes in membrane potential at pH 5.0 for PVC matrix liquid membranes incorporated with o-Tolyloxy-acetic acid decyl ester polymer [AID18737, Type: Literature]
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45
[SID103174520]
Selectivity of guest-induced changes in membrane potential at pH 5.0 for PVC matrix liquid membranes incorporated with o-Tolyloxy-acetic acid ethyl ester polymer [AID18738, Type: Literature]
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46
[SID103174520]
Selectivity of guest-induced changes in membrane potential at pH 5.0 for PVC matrix liquid membranes incorporated with (2-Butoxy-5-tert-butyl-3-methyl-phenyl)-methanol polymer [AID18739, Type: Literature]
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47
[SID103174520]
Selectivity of guest-induced changes in membrane potential(Kpot A,B) at pH 5.0 for PVC matrix liquid membranes incorporated with 6,7,9,10,17,18,20,21-Octahydro-5,8,11,16,19,22-hexaoxa-dibenzo[a,j]cyclooctadecene [AID18741, Type: Literature]
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48
[SID103174520]
Partition coefficient (logP) [AID23236, Type: Literature]
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49
[SID103174520]
Inhibition of [3H]clonidine binding to the rat alpha-2-adrenoreceptor [AID35395, Type: Literature]
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50
[SID103174520]
Ratio of Ki for rat brain NMDA receptor in presence of 100 uM spermine to Ki for rat brain NMDA receptor in absence of spermine [AID353104, Type: Literature]
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