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Glycine (CID 750) - Compound BioActivity Data
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BioActivity Outcomes:
Active(29)
 
 
Inactive(228)
 
 
Inconclusive(15)
 
 
Unspecified(271)
 
 
Top Targets:
p450(25)
 
 
 
 
7TM GPCR Srsx(18)
 
 
 
7TM GPCR Srx(16)
 
 
NR LBD ER(9)
 
 
 
NR LBD PPAR(8)
 
 
BioAssay Types:
Confirmatory(297)
 
 
 
 
Literature(95)
 
 
 
 
 
Summary(24)
 
 
Screening(8)
 
 
BioActivity Types:
Potency(179)
 
 
 
IC50(137)
 
 
 
 
EC50(8)
 
 
 
 
Ki(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 506    Data Row: 543   Total Pages: 28   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103204298]
EC50 0.068In vitro concentration eliciting half-maximal effect on [3H]-MK 801 radioligand binding to NMDA receptor [AID145252, Type: Literature]
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2
[SID103204298]
IC50 0.086Tested for binding affinity against NMDA receptor, from rat synaptic membrane, using [3H]glycine as the radioligand. [AID143072, Type: Literature]
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3
[SID103204298]
EC50 0.096Effective concentration against NR1/NR2D receptor [AID146064, Type: Literature]
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4
[SID103204298]
Ki 0.12589Displacement of [3H]glycine from strychnine-insensitive glycine recognition site of NMDA receptor in rat brain cortex membrane [AID430782, Type: Literature]
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5
[SID103204298]
EC50 0.15Effective concentration against NR1/NR2C receptor [AID146062, Type: Literature]
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6
[SID103204298]
Ki 0.17Affinity for the glycine binding site of NMDA receptor by inhibition of [3H]5,7-dichlorokynurenic acid ([3H]DCKA) binding to rat brain synaptic membrane [AID143084, Type: Literature]
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7
[SID103204298]
EC50 0.19Effective concentration against NR1/NR2B receptor [AID146060, Type: Literature]
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8
[SID103204298]
EC50 0.2Compound was evaluated for in vitro inhibition of [3H]TCP at NMDA receptor [AID144825, Type: Literature]
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9
[SID103204298]
IC50 0.2In vitro inhibition of [3H]glycine at NMDA receptor [AID145260, Type: Literature]
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10
[SID103204298]
IC50 0.223Inhibition of rat glutamate receptor [AID566258, Type: Literature]
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11
[SID103204298]
IC50 0.25In vitro inhibitory activity to inhibit [3H]glycine binding to NMDA receptor [AID143065, Type: Literature]
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12
[SID103204298]
IC50 0.69Binding affinity against glycine binding site associated with N-methyl-D-aspartate glutamate receptor of rat synaptic plasma membrane(SPM) determined using [3H]glycine as radioligand. [AID144598, Type: Literature]
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13
[SID103204298]
EC50 0.84Effective concentration against NR1/NR2A receptor [AID146058, Type: Literature]
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14
[SID103204298]
IC50 6Inhibition of binding of [3H]strychnine to glycine receptor in rat [AID143467, Type: Literature]
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15
[SID103204298]
IC50 6.2Inhibitory concentration required to inhibit [3H]strychnine binding to N-methyl-D-aspartate glutamate receptor 1 [AID143614, Type: Literature]
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16
[SID103204298]
IC50 15.8Displacement of [3H]strychnine from strychnine-sensitive glycine receptor in rat spinal cord [AID270051, Type: Literature]
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17
[SID103204298]
IC50 15.8Displacement of [3H]strychnine from glycine receptor in rat spinal cord synaptosomal membranes [AID286349, Type: Literature]
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18
[SID103204298]
IC50 31.6Inhibition of GlyT1 (unknown origin) assessed as inhibition of [14C]glycine uptake [AID1070046, Type: Literature]Sodium- and chloride-dependent glycine transporter 1 [gi:302393807]
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19
[SID103204298]
Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins [AID678714, Type: Literature]Cytochrome P450 2C19 [gi:60416369]
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20
[SID103204298]
Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins [AID678713, Type: Literature]Cytochrome P450 2C9 [gi:6686268]
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