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Glycine (CID 750) - Compound BioActivity Data
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BioActivity Outcomes:
Active(28)
 
 
Inactive(228)
 
 
Inconclusive(15)
 
 
Unspecified(271)
 
 
Top Targets:
p450(25)
 
 
 
 
7TM GPCR Srsx(18)
 
 
 
7TM GPCR Srx(17)
 
 
NR LBD ER(9)
 
 
 
NR LBD PPAR(8)
 
 
BioAssay Types:
Confirmatory(297)
 
 
 
 
Literature(94)
 
 
 
 
 
Summary(24)
 
 
Screening(8)
 
 
BioActivity Types:
Potency(179)
 
 
 
IC50(136)
 
 
 
 
EC50(8)
 
 
 
 
Ki(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 505    Data Row: 542   Total Pages: 28   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103204298]
EC50 0.068In vitro concentration eliciting half-maximal effect on [3H]-MK 801 radioligand binding to NMDA receptor [AID145252, Type: Literature]
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2
[SID103204298]
IC50 0.086Tested for binding affinity against NMDA receptor, from rat synaptic membrane, using [3H]glycine as the radioligand. [AID143072, Type: Literature]
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3
[SID103204298]
EC50 0.096Effective concentration against NR1/NR2D receptor [AID146064, Type: Literature]
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4
[SID103204298]
Ki 0.12589Displacement of [3H]glycine from strychnine-insensitive glycine recognition site of NMDA receptor in rat brain cortex membrane [AID430782, Type: Literature]
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5
[SID103204298]
EC50 0.15Effective concentration against NR1/NR2C receptor [AID146062, Type: Literature]
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6
[SID103204298]
Ki 0.17Affinity for the glycine binding site of NMDA receptor by inhibition of [3H]5,7-dichlorokynurenic acid ([3H]DCKA) binding to rat brain synaptic membrane [AID143084, Type: Literature]
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7
[SID103204298]
EC50 0.19Effective concentration against NR1/NR2B receptor [AID146060, Type: Literature]
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8
[SID103204298]
EC50 0.2Compound was evaluated for in vitro inhibition of [3H]TCP at NMDA receptor [AID144825, Type: Literature]
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9
[SID103204298]
IC50 0.2In vitro inhibition of [3H]glycine at NMDA receptor [AID145260, Type: Literature]
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10
[SID103204298]
IC50 0.223Inhibition of rat glutamate receptor [AID566258, Type: Literature]
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11
[SID103204298]
IC50 0.25In vitro inhibitory activity to inhibit [3H]glycine binding to NMDA receptor [AID143065, Type: Literature]
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12
[SID103204298]
IC50 0.69Binding affinity against glycine binding site associated with N-methyl-D-aspartate glutamate receptor of rat synaptic plasma membrane(SPM) determined using [3H]glycine as radioligand. [AID144598, Type: Literature]
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13
[SID103204298]
EC50 0.84Effective concentration against NR1/NR2A receptor [AID146058, Type: Literature]
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14
[SID103204298]
IC50 6Inhibition of binding of [3H]strychnine to glycine receptor in rat [AID143467, Type: Literature]
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15
[SID103204298]
IC50 6.2Inhibitory concentration required to inhibit [3H]strychnine binding to N-methyl-D-aspartate glutamate receptor 1 [AID143614, Type: Literature]
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16
[SID103204298]
IC50 15.8Displacement of [3H]strychnine from strychnine-sensitive glycine receptor in rat spinal cord [AID270051, Type: Literature]
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17
[SID103204298]
IC50 15.8Displacement of [3H]strychnine from glycine receptor in rat spinal cord synaptosomal membranes [AID286349, Type: Literature]
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18
[SID103204298]
Binding affinity to 30 mM pyridoxal-5'-phosphate assessed as formation of PLP-aldimine by ESI-MS analysis [AID443653, Type: Literature]
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19
[SID48413824]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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20
[SID48413824]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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