methylparaben (CID 7456) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(7)
 
 
Inactive(550)
 
 
Inconclusive(10)
 
 
Unspecified(158)
 
 
Top Targets:
7TM GPCR Srx(29)
 
 
 
7TM GPCR Srsx(16)
 
 
 
p450(8)
 
 
NR LBD TR(6)
 
 
NR LBD PPAR(5)
 
 
BioAssay Types:
Screening(259)
 
 
 
Confirmatory(208)
 
 
 
 
 
Literature(97)
 
 
 
 
 
BioActivity Types:
Potency(181)
 
 
 
 
 
IC50(142)
 
 
 
 
EC50(6)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 617    Data Row: 725   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26754470]
Potency 19.3312qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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2
[SID26754470]
Potency 19.3312qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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3
[SID26754470]
Potency 19.3312qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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4
[SID26754470]
Potency 19.3312qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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5
[SID103329864]
IC50 23Phytotoxicity against Amaranthus hypochondriacus assessed as inhibition of radicle elongation [AID380384, Type: Literature]
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6
[SID103329864]
 Binding affinity to spinach calmodulin at 0.033 ug/mL after 1.5 hrs by electrophoretic mobility assay in presence of calcium chloride [AID380388, Type: Literature]Calmodulin [gi:122063217]
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7
[SID103329864]
 Binding affinity to spinach calmodulin at 0.033 ug/mL after 1.5 hrs by electrophoretic mobility assay presence of EGTA [AID380389, Type: Literature]Calmodulin [gi:122063217]
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8
[SID48416256]
 DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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9
[SID48422035]
 DSSTox (NCTRER) National Center for Toxicological Research Estrogen Receptor Binding Database [AID1204, Type: screening]
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10
[SID103329864]
 Binding affinity to bovine brain calmodulin at 0.033 ug/mL after 1.5 hrs by electrophoretic mobility assay in presence of calcium chloride [AID380386, Type: Literature]Calmodulin [gi:49037473]
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11
[SID103329864]
IC50 50Inhibition of xanthine oxidase-mediated formation of uric acid by spectrophotometry [AID336485, Type: Literature]
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12
[SID103329864]
IC50 200Antitumor activity against KB cells by MTT assay [AID290547, Type: Literature]
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13
[SID103329864]
IC50 200Antitumor activity against KBv200 cells by MTT assay [AID290548, Type: Literature]
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14
[SID103329864]
IC50 426.58Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) [AID255211, Type: Literature]
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15
[SID103329864]
IC50 630Phytotoxicity against Echinochloa crusgalli assessed as inhibition of radicle elongation [AID380385, Type: Literature]
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16
[SID103329864]
IC50 1995.26Inhibition of Bacillus subtilis PCI219 spore germination, expressed as log 1/I50 [AID40936, Type: Literature]
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17
[SID103329864]
IC50 2010Inhibitory activity on germination of Bacillus subtilis PCI219 spores was determined. [AID40623, Type: Literature]
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18
[SID103329864]
 Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay [AID372895, Type: Literature]
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19
[SID103329864]
 Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay [AID372896, Type: Literature]
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20
[SID103329864]
 Antibacterial activity against Streptococcus faecalis ATCC 9790 after 24 hrs by MTT assay [AID372897, Type: Literature]
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21
[SID103329864]
 Antibacterial activity against sPseudomonas aeruginosa ATCC 13525 after 24 hrs by MTT assay [AID372898, Type: Literature]
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22
[SID103329864]
 Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay [AID372899, Type: Literature]
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23
[SID103329864]
 Antibacterial activity against Enterobacter cloacae ATCC 13047 after 24 hrs by MTT assay [AID372900, Type: Literature]
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24
[SID103329864]
IC50 DRUGMATRIX: Nicotinic Acetylcholine radioligand binding (ligand: [125I] Epibatidine) [AID625158, Type: other]
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25
[SID103329864]
 DRUGMATRIX: Phorbol Ester radioligand binding (ligand: [3H] PDBu) [AID625164, Type: other]
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26
[SID103329864]
IC50 DRUGMATRIX: Phosphodiesterase PDE3 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625165, Type: other]
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27
[SID103329864]
IC50 DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625166, Type: other]
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28
[SID103329864]
 DRUGMATRIX: Platelet-Derived Growth Factor (PDGF) radioligand binding (ligand: [125I] PDGF) [AID625169, Type: other]
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29
[SID103329864]
IC50 DRUGMATRIX: Potassium Channel [KATP] radioligand binding (ligand: [3H] Glyburide) [AID625170, Type: other]
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30
[SID103329864]
 DRUGMATRIX: Purinergic P2X radioligand binding (ligand: [3H] alpha, beta-Methylene-ATP) [AID625189, Type: other]
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31
[SID103329864]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) [AID625190, Type: other]
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32
[SID103329864]
IC50 DRUGMATRIX: Sodium/nucleoside co-transporter radioligand binding (ligand: nitrobenzylthioinosine) [AID625197, Type: other]
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33
[SID103329864]
IC50 DRUGMATRIX: ATPase, Na+/K+ enzyme inhibition (substrate: ATP) [AID625210, Type: other]
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34
[SID103329864]
 DRUGMATRIX: Atrial Natriuretic Factor (ANF) radioligand binding (ligand: [125I] ANF (rat)) [AID625211, Type: other]
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35
[SID103329864]
IC50 DRUGMATRIX: beta-Lactamase enzyme inhibition (substrate: Nitrocefin) [AID625212, Type: other]
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36
[SID103329864]
IC50 DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) [AID625215, Type: other]
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37
[SID103329864]
IC50 DRUGMATRIX: Calcium Channel Type L, Dihydropyridine radioligand binding (ligand: [3H] Nitrendipine) [AID625216, Type: other]
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38
[SID103329864]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT3 radioligand binding (ligand: [3H] GR-65630) [AID625219, Type: other]
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39
[SID103329864]
IC50 DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil) [AID625224, Type: other]
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40
[SID103329864]
IC50 DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) [AID625225, Type: other]
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41
[SID103329864]
 DRUGMATRIX: Tumor Necrosis Factor (TNF), Non-Selective radioligand binding (ligand: [125I] TNF-alpha) [AID625230, Type: other]
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42
[SID103329864]
IC50 DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: other]
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43
[SID103329864]
IC50 DRUGMATRIX: GABAA, Muscimol, Central radioligand binding (ligand: [3H] Muscimol) [AID625260, Type: other]
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44
[SID103329864]
IC50 DRUGMATRIX: GABAA, Flunitrazepam, Central radioligand binding (ligand: [3H] Flunitrazepam) [AID625261, Type: other]
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45
[SID103329864]
IC50 DRUGMATRIX: GABAA, Chloride Channel, TBOB radioligand binding (ligand: [3H] TBOB) [AID625262, Type: other]
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46
[SID103329864]
IC50 DRUGMATRIX: Glutamate, AMPA radioligand binding (ligand: [3H] AMPA) [AID625264, Type: other]
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47
[SID103329864]
 DRUGMATRIX: Glutamate, Kainate radioligand binding (ligand: [3H] Kainic acid) [AID625265, Type: other]
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48
[SID103329864]
IC50 DRUGMATRIX: Glutamate, NMDA, Agonism radioligand binding (ligand: [3H] CGP-39653) [AID625266, Type: other]
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49
[SID103329864]
IC50 DRUGMATRIX: Glutamate, NMDA, Phencyclidine radioligand binding (ligand: [3H] TCP) [AID625267, Type: other]
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50
[SID103329864]
IC50 DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) [AID625268, Type: other]
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