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methylparaben (CID 7456) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(15)
 
 
Inactive(856)
 
 
Inconclusive(50)
 
 
Unspecified(158)
 
 
Top Targets:
7TM GPCR Srx(36)
 
 
 
7TM GPCR Srsx(32)
 
 
 
NR LBD PPAR(29)
 
 
 
NR LBD ER(25)
 
 
 
 
NR LBD AR(24)
 
 
 
 
BioAssay Types:
Confirmatory(428)
 
 
 
 
 
Screening(315)
 
 
 
Literature(103)
 
 
 
 
 
Summary(72)
 
 
 
BioActivity Types:
Potency(451)
 
 
 
 
 
IC50(144)
 
 
 
 
Ki(6)
 
 
EC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 752    Data Row: 1079   Total Pages: 22   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103329864]
Ki 0.78Inhibition of human carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID729536, Type: Literature]Carbonic anhydrase 7 [gi:1168744]
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2
[SID103329864]
Ki 0.82Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID729534, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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3
[SID103329864]
Ki 2.6Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID729538, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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4
[SID103329864]
Ki 3.4Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID729537, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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5
[SID103329864]
Ki 4.1Inhibition of human carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID729533, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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6
[SID103329864]
Ki 5.5Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID729535, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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7
[SID26754470]
Potency 19.3312qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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8
[SID103329864]
IC50 23Phytotoxicity against Amaranthus hypochondriacus assessed as inhibition of radicle elongation [AID380384, Type: Literature]
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9
[SID144209516]
Potency-Replicate_1 55.0372qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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10
[SID144209516]
Potency-Replicate_1 69.2877qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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11
[SID103329864]
Binding affinity to spinach calmodulin at 0.033 ug/mL after 1.5 hrs by electrophoretic mobility assay in presence of calcium chloride [AID380388, Type: Literature]Calmodulin [gi:122063217]
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12
[SID103329864]
Binding affinity to spinach calmodulin at 0.033 ug/mL after 1.5 hrs by electrophoretic mobility assay presence of EGTA [AID380389, Type: Literature]Calmodulin [gi:122063217]
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13
[SID103329864]
Binding affinity to bovine brain calmodulin at 0.033 ug/mL after 1.5 hrs by electrophoretic mobility assay in presence of calcium chloride [AID380386, Type: Literature]Calmodulin [gi:49037473]
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14
[SID48416256]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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15
[SID48422035]
DSSTox (NCTRER) National Center for Toxicological Research Estrogen Receptor Binding Database [AID1204, Type: screening]
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16
[SID103329864]
IC50 50Inhibition of xanthine oxidase-mediated formation of uric acid by spectrophotometry [AID336485, Type: Literature]
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17
[SID103329864]
IC50 200Antitumor activity against KB cells by MTT assay [AID290547, Type: Literature]
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18
[SID103329864]
IC50 200Antitumor activity against KBv200 cells by MTT assay [AID290548, Type: Literature]
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19
[SID103329864]
IC50 426.58Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) [AID255211, Type: Literature]
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20
[SID103329864]
IC50 630Phytotoxicity against Echinochloa crusgalli assessed as inhibition of radicle elongation [AID380385, Type: Literature]
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21
[SID103329864]
IC50 2010Inhibitory activity on germination of Bacillus subtilis PCI219 spores was determined. [AID40623, Type: Literature]
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22
[SID103329864]
Inhibition of Bacillus subtilis PCI219 spore germination, expressed as log 1/I50 [AID40936, Type: Literature]
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23
[SID103329864]
ABTS radical scavenging activity assessed as Trolox equivalent antioxidant capacity at 1 mM by spectrophotometry [AID336484, Type: Literature]
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24
[SID103329864]
Dissociation constant was determined at pH 7.2 [AID25608, Type: Literature]
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25
[SID103329864]
Dissociation constant (pKa) [AID25611, Type: Literature]
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26
[SID103329864]
Partition coefficient (logP) [AID26793, Type: Literature]
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27
[SID29215301]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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28
[SID50085960]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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29
[SID103329864]
Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT assay [AID372895, Type: Literature]
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30
[SID103329864]
Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT assay [AID372896, Type: Literature]
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31
[SID103329864]
Antibacterial activity against Streptococcus faecalis ATCC 9790 after 24 hrs by MTT assay [AID372897, Type: Literature]
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32
[SID103329864]
Antibacterial activity against sPseudomonas aeruginosa ATCC 13525 after 24 hrs by MTT assay [AID372898, Type: Literature]
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33
[SID103329864]
Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay [AID372899, Type: Literature]
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34
[SID103329864]
Antibacterial activity against Enterobacter cloacae ATCC 13047 after 24 hrs by MTT assay [AID372900, Type: Literature]
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35
[SID103329864]
IC50 DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) [AID625270, Type: other]Histamine H2 receptor [gi:123120]
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36
[SID103329864]
IC50 DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) [AID625271, Type: other]3-hydroxy-3-methylglutaryl-coenzyme A reductase [gi:123343]
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37
[SID103329864]
IC50 DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) [AID625273, Type: other]Insulin receptor [gi:124531]
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38
[SID103329864]
IC50 DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625185, Type: other]Tyrosine-protein kinase Fyn [gi:125370]
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39
[SID103329864]
IC50 DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625187, Type: other]Tyrosine-protein kinase Lck [gi:125474]
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40
[SID103329864]
IC50 DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) [AID625146, Type: other]Arachidonate 15-lipoxygenase [gi:126397]
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41
[SID103329864]
IC50 DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) [AID625226, Type: other]Substance-P receptor [gi:128359]
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42
[SID103329864]
IC50 DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
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43
[SID103329864]
DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) [AID625156, Type: other]Neuropeptide Y receptor type 1 [gi:128997]
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44
[SID103329864]
IC50 DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) [AID625168, Type: other]Platelet-activating factor receptor [gi:129557]
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45
[SID103329864]
Specific activity of expressed human recombinant UGT1A1 [AID624606, Type: Literature]UDP-glucuronosyltransferase 1-1 [gi:136729]
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46
[SID103329864]
IC50 DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) [AID625236, Type: other]Carbonic anhydrase 2 [gi:115456]
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47
[SID103329864]
IC50 DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) [AID625235, Type: other]Cannabinoid receptor 1 [gi:115562]
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48
[SID103329864]
IC50 DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) [AID625175, Type: other]Cathepsin G [gi:115725]
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49
[SID103329864]
IC50 DRUGMATRIX: Peptidase, Matrix Metalloproteinase-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) [AID625177, Type: other]Interstitial collagenase [gi:116852]
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50
[SID103329864]
IC50 DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625245, Type: other]Cytochrome P450 1A2 [gi:117144]
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