Bookmark and Share
1-(4-Chlorophenylmethyl)-2-aminobenzimidazole (CID 743900) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(10)
 
 
Inactive(13)
 
 
Inconclusive(1)
 
 
Unspecified(8)
 
 
Top Targets:
NACHT(6)
 
 
Chemokine CXC(3)
 
 
TNF(2)
 
 
 
DNA pol B 3(1)
 
 
DUF3346(1)
 
 
BioAssay Types:
Confirmatory(11)
 
 
 
Literature(6)
 
 
 
 
BioActivity Types:
IC50(15)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 28    Data Row: 32   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85285640]
IC50 4.593SAR analysis of Muramyl dipeptide (MDP) induced IL-8 secretion in MCF-7/NOD2 cells - Set 2 [AID2503, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
2
[SID136923738]
IC50 7.7Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by reporter gene assay [AID655843, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 1 [gi:20137579]
View
3
[SID85285640]
IC50_Mean 7.73SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
View
4
[SID87225518]
IC50_Mean 8.92SAR analysis of inhibitors of TNFa specific NF-kB induction revised [AID2337, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
View
5
[SID87225518]
IC50_Mean 9.5SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
View
6
[SID87225518]
IC50_Mean 11.7SAR analysis of compounds that inhibit NOD2 revised [AID2334, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 isoform 1 [Homo sapiens] [gi:11545912]
View
7
[SID85285640]
IC50_Mean 11.8SAR analysis of compounds that inhibit NOD2 revised [AID2334, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 isoform 1 [Homo sapiens] [gi:11545912]
View
8
[SID136923738]
IC50 11.9Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay [AID655844, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 2 [gi:20137973]
View
9
[SID85285640]
IC50 12.11SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2505, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
10
[SID85285640]
IC50 19.84SAR analysis of Tumor necrosis factor alpha (TNF-alpha) induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2504, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
11
[SID136923738]
IC50 20Inhibition of TNFalpha-induced NFkappaB activation in HEK293T cells after 14 hrs by luciferase reporter gene assay [AID655845, Type: Literature]
View
12
[SID136923738]
IC50 100Inhibition of N-terminus His-tagged Francisella tularensis subsp. Tularensis Schu4 Fab1 expressed in Escherichia coli DL21 (DE3) cells assessed as conversion of crotonyl-CoA and NADH to butyryl-CoA and NAD+ preincubated for 30 mins by measured fluorescence analysis [AID643269, Type: Literature]
View
13
[SID136923738]
Cytotoxicity against HEK293T cells at 20 uM by alamar blue assay [AID655846, Type: Literature]
View
14
[SID136923738]
In vitro antifungal activity against Botryotinia fuckeliana assessed as inhibition at 0.1 % [AID1098913, Type: other]
View
15
[SID136923738]
In vitro antibacterial activity against Pseudomonas viridiflava 8 assessed as inhibition at 0.1 % [AID1098914, Type: other]
View
16
[SID136923738]
In vitro antibacterial activity against Pseudomonas syringae pv. glycinea S1 assessed as inhibition at 0.1 % [AID1098916, Type: other]
View
17
[SID136923738]
In vitro antibacterial activity against Pseudomonas syringae pv. phaseolicola E81 assessed as inhibition at 0.1 % [AID1098917, Type: other]
View
18
[SID136923738]
In vitro antibacterial activity against Xanthomonas campestris pv. campestris KF2 assessed as inhibition at 0.1 % [AID1098918, Type: other]
View
19
[SID85285640]
IC50_Mean 20SAR analysis of compounds that are cytotoxic to HEK293 revised [AID2335, Type: confirmatory]
View
20
[SID87225518]
IC50_Mean 20SAR analysis of compounds that are cytotoxic to HEK293 revised [AID2335, Type: confirmatory]
View