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1-(4-Chlorophenylmethyl)-2-aminobenzimidazole (CID 743900) - Compound BioActivity Data
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BioActivity Outcomes:
Active(10)
 
 
Inactive(11)
 
 
Unspecified(3)
 
 
Top Targets:
NACHT(6)
 
 
Chemokine CXC(3)
 
 
TNF(2)
 
 
 
Chorismate bi..(1)
 
 
HTH MARR(1)
 
 
BioAssay Types:
Confirmatory(11)
 
 
 
Literature(6)
 
 
 
 
BioActivity Types:
IC50(15)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 20    Data Row: 24   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85285640]
IC50 4.593SAR analysis of Muramyl dipeptide (MDP) induced IL-8 secretion in MCF-7/NOD2 cells - Set 2 [AID2503, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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2
[SID136923738]
IC50 7.7Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by reporter gene assay [AID655843, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 1 [gi:20137579]
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3
[SID85285640]
IC50_Mean 7.73SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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4
[SID87225518]
IC50_Mean 8.92SAR analysis of inhibitors of TNFa specific NF-kB induction revised [AID2337, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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5
[SID87225518]
IC50_Mean 9.5SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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6
[SID87225518]
IC50_Mean 11.7SAR analysis of compounds that inhibit NOD2 revised [AID2334, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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7
[SID85285640]
IC50_Mean 11.8SAR analysis of compounds that inhibit NOD2 revised [AID2334, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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8
[SID136923738]
IC50 11.9Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay [AID655844, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 2 [gi:20137973]
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9
[SID85285640]
IC50 12.11SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2505, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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10
[SID85285640]
IC50 19.84SAR analysis of Tumor necrosis factor alpha (TNF-alpha) induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2504, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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11
[SID136923738]
IC50 20Inhibition of TNFalpha-induced NFkappaB activation in HEK293T cells after 14 hrs by luciferase reporter gene assay [AID655845, Type: Literature]
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12
[SID136923738]
IC50 100Inhibition of N-terminus His-tagged Francisella tularensis subsp. Tularensis Schu4 Fab1 expressed in Escherichia coli DL21 (DE3) cells assessed as conversion of crotonyl-CoA and NADH to butyryl-CoA and NAD+ preincubated for 30 mins by measured fluorescence analysis [AID643269, Type: Literature]
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13
[SID136923738]
Cytotoxicity against HEK293T cells at 20 uM by alamar blue assay [AID655846, Type: Literature]
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14
[SID85285640]
IC50_Mean 20SAR analysis of compounds that are cytotoxic to HEK293 revised [AID2335, Type: confirmatory]
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15
[SID87225518]
IC50_Mean 20SAR analysis of compounds that are cytotoxic to HEK293 revised [AID2335, Type: confirmatory]
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16
[SID85285640]
IC50_Mean 20SAR analysis of inhibitors of TNFa specific NF-kB induction revised [AID2337, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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17
[SID92245225]
A screen for compounds that inhibit processive DNA synthesis of vaccinia virus [AID493162, Type: other]DNA polymerase [Vaccinia virus] [gi:335756]
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18
[SID92245225]
A screen for compounds that inhibit replication of Vibrio cholerae chromosome II [AID504770, Type: other]hypothetical protein VC_A0002 [Vibrio cholerae O1 biovar El Tor str. N16961] [gi:9657380]
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19
[SID92245225]
A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus [AID720641, Type: other]anion-binding protein [Staphylococcus aureus subsp. aureus Mu50] [gi:15923709]
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20
[SID92245225]
A screen for compounds that inhibit the CapD enzyme of Bacillus anthracis [AID492967, Type: other]gamma-glutamyltranspeptidase [Bacillus anthracis str. 'Ames Ancestor'] [gi:47566732]
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