1-(4-Chlorophenylmethyl)-2-aminobenzimidazole (CID 743900) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(10)
 
 
Inactive(10)
 
 
Unspecified(3)
 
 
Top Targets:
CARD NOD1 CAR..(3)
 
 
Chemokine CXC(3)
 
 
CARD NOD2 1 C..(2)
 
 
TNF(2)
 
 
 
Chorismate bi..(1)
 
 
BioAssay Types:
Confirmatory(11)
 
 
 
Literature(6)
 
 
 
 
BioActivity Types:
IC50(15)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 19    Data Row: 23   Total Pages: 1   
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85285640]
IC50 4.593SAR analysis of Muramyl dipeptide (MDP) induced IL-8 secretion in MCF-7/NOD2 cells - Set 2 [AID2503, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
2
[SID85285640]
IC50 4.593SAR analysis of Muramyl dipeptide (MDP) induced IL-8 secretion in MCF-7/NOD2 cells - Set 2 [AID2503, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
3
[SID85285640]
IC50 4.593SAR analysis of Muramyl dipeptide (MDP) induced IL-8 secretion in MCF-7/NOD2 cells - Set 2 [AID2503, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
4
[SID136923738]
IC50 7.7Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by reporter gene assay [AID655843, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 1 [gi:20137579]
View
5
[SID136923738]
IC50 7.7Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by reporter gene assay [AID655843, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 1 [gi:20137579]
View
6
[SID85285640]
IC50 7.73SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
View
7
[SID85285640]
IC50 7.73SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
View
8
[SID87225518]
IC50 8.92SAR analysis of inhibitors of TNFa specific NF-kB induction revised [AID2337, Type: confirmatory]TNF gene product [Homo sapiens] [gi:25952111]
View
9
[SID87225518]
IC50 8.92SAR analysis of inhibitors of TNFa specific NF-kB induction revised [AID2337, Type: confirmatory]TNF gene product [Homo sapiens] [gi:25952111]
View
10
[SID87225518]
IC50 9.5SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
View
11
[SID87225518]
IC50 9.5SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
View
12
[SID87225518]
IC50 11.7SAR analysis of compounds that inhibit NOD2 revised [AID2334, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
View
13
[SID87225518]
IC50 11.7SAR analysis of compounds that inhibit NOD2 revised [AID2334, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
View
14
[SID87225518]
IC50 11.7SAR analysis of compounds that inhibit NOD2 revised [AID2334, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
View
15
[SID85285640]
IC50 11.8SAR analysis of compounds that inhibit NOD2 revised [AID2334, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
View
16
[SID85285640]
IC50 11.8SAR analysis of compounds that inhibit NOD2 revised [AID2334, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
View
17
[SID85285640]
IC50 11.8SAR analysis of compounds that inhibit NOD2 revised [AID2334, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
View
18
[SID136923738]
IC50 11.9Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay [AID655844, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 2 [gi:20137973]
View
19
[SID136923738]
IC50 11.9Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay [AID655844, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 2 [gi:20137973]
View
20
[SID136923738]
IC50 11.9Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay [AID655844, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 2 [gi:20137973]
View
21
[SID85285640]
IC50 12.11SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2505, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
22
[SID85285640]
IC50 12.11SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2505, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
23
[SID85285640]
IC50 12.11SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2505, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
24
[SID85285640]
IC50 19.84SAR analysis of Tumor necrosis factor alpha (TNF-alpha) induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2504, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
25
[SID85285640]
IC50 19.84SAR analysis of Tumor necrosis factor alpha (TNF-alpha) induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2504, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
26
[SID85285640]
IC50 19.84SAR analysis of Tumor necrosis factor alpha (TNF-alpha) induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2504, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
27
[SID136923738]
IC50 20Inhibition of TNFalpha-induced NFkappaB activation in HEK293T cells after 14 hrs by luciferase reporter gene assay [AID655845, Type: Literature]
View
28
[SID136923738]
IC50 100Inhibition of N-terminus His-tagged Francisella tularensis subsp. Tularensis Schu4 Fab1 expressed in Escherichia coli DL21 (DE3) cells assessed as conversion of crotonyl-CoA and NADH to butyryl-CoA and NAD+ preincubated for 30 mins by measured fluorescence analysis [AID643269, Type: Literature]
View
29
[SID136923738]
 Cytotoxicity against HEK293T cells at 20 uM by alamar blue assay [AID655846, Type: Literature]
View
30
[SID85285640]
IC50 20SAR analysis of compounds that are cytotoxic to HEK293 revised [AID2335, Type: confirmatory]
View
31
[SID87225518]
IC50 20SAR analysis of compounds that are cytotoxic to HEK293 revised [AID2335, Type: confirmatory]
View
32
[SID85285640]
IC50 20SAR analysis of inhibitors of TNFa specific NF-kB induction revised [AID2337, Type: confirmatory]TNF gene product [Homo sapiens] [gi:25952111]
View
33
[SID85285640]
IC50 20SAR analysis of inhibitors of TNFa specific NF-kB induction revised [AID2337, Type: confirmatory]TNF gene product [Homo sapiens] [gi:25952111]
View
34
[SID92245225]
 A screen for compounds that inhibit processive DNA synthesis of vaccinia virus [AID493162, Type: other]DNA polymerase [Vaccinia virus] [gi:335756]
View
35
[SID92245225]
 A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities [AID588519, Type: Literature]Chain A, Poliovirus Polymerase With Gtp [gi:52695378]
View
36
[SID92245225]
 A screen for compounds that inhibit the bacterial siderophore biosynthetic enzyme MbtI [AID493033, Type: other]Isochorismate synthase/isochorismate-pyruvate lyase mbtI [gi:81706979]
View
37
[SID92245225]
 A screen for compounds that inhibit replication of Vibrio cholerae chromosome II [AID504770, Type: other]hypothetical protein VC_A0002 [Vibrio cholerae O1 biovar El Tor str. N16961] [gi:9657380]
View
38
[SID92245225]
 A screen for compounds that inhibit the CapD enzyme of Bacillus anthracis [AID492967, Type: other]gamma-glutamyltranspeptidase [Bacillus anthracis str. 'Ames Ancestor'] [gi:47566732]
View
39
[SID92245225]
 A screen for compounds that inhibit the activity of Staphylococcus aureus DNA helicase [AID485395, Type: other]replicative DNA helicase [Staphylococcus aureus subsp. aureus JH1] [gi:150392496]
View
40
[SID92245225]
 A screen for compounds that modulate the activity of the Staphylococcus aureus MgrA protein [AID602314, Type: other]MarR family regulatory protein [Staphylococcus aureus subsp. aureus str. Newman] [gi:151220867]
View