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BioActivity Data for Compound Trehalose (CID 7427)

BioActivity Outcomes:
Active(5)
 
 
Inactive(3)
 
 
Unspecified(2)
 
 
Top Targets:
DUF3652(3)
 
 
HAD like(3)
 
 
BioAssay Types:
Literature(3)
 
 
BioAssay Categories:
Biochemical(3)
 
 
Toxicity(1)
 
 
ADME(1)
 
 
Cell-based(3)
 
 
BioActivity Types:
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 9    Data Row: 10   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID53812562]
Ki 26000Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, X-ray Structure Of The Sucrose-phosphatase (spp) From Synechocystis Sp.pcc6803 In Complex With Trehalose [gi:116666757]
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2
[SID53812562]
Ki 26000Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, X-ray Structure Of The Sucrose-phosphatase (spp) From Synechocystis Sp.pcc6803 In Complex With Trehalose [gi:116666757]
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3
[SID104252533]
Inhibition of mutated huntingtin aggregate formation in liver homogenate of R6/2 transgenic mouse at 1%, po after 4 to 8 weeks by Western blotting analysis [AID1120457, Type: other]
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4
[SID104252533]
Inhibition of mutated aggregate formation in brain homogenate of R6/2 transgenic mouse at 1%, po by Hoechst staining-based by immunohistochemistry [AID1120462, Type: other]
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5
[SID53812562]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, X-ray Structure Of The Sucrose-phosphatase (spp) From Synechocystis Sp.pcc6803 In Complex With Trehalose [gi:116666757]
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6
[SID104252533]
Toxicity in R6/2 transgenic mouse assessed as body weight loss at 1%, po measured on week 12 [AID1120466, Type: other]
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7
[SID104252533]
Neuroprotective activity in R6/2 transgenic mouse assessed as increased mean survival time at 1%, po (Rvb = 93 days) [AID1120469, Type: other]
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8
[SID104252533]
Inhibition of N-terminal GFP-tagged Htt-exon1-Q103 (unknown origin) transfected in Neuro2a cells assessed as reduction of Htt-Q103 aggregate formation at 100 uM by fluorescence microscopic analysis [AID1120475, Type: other]Huntingtin [gi:296434520]
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9
[SID104252533]
Inhibition of N-terminal GFP-tagged Htt-exon1-Q103 (unknown origin) transfected in HEK293A cells assessed as reduction of Htt-Q103 aggregate formation at 200 uM by filter trap assay [AID1120476, Type: other]Huntingtin [gi:296434520]
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10
[SID104252533]
Inhibition of N-terminal GFP-tagged Htt-exon1-Q103 (unknown origin) transfected in HEK293A cells assessed as reduction of Htt-Q103 aggregate formation at 50 uM after 3 days by fluorescence microscopic analysis [AID1120479, Type: other]Huntingtin [gi:296434520]
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