AE-848/34926026 (CID 740387) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(40)
 
 
Inactive(420)
 
 
Inconclusive(26)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
TRP 2(9)
 
 
 
7TM GPCR Srsx(6)
 
 
alkPPc(4)
 
 
KCNQ channel(4)
 
 
BioAssay Types:
Screening(330)
 
 
 
 
Confirmatory(141)
 
 
 
 
 
Literature(7)
 
 
BioActivity Types:
Potency(102)
 
 
 
 
 
IC50(27)
 
 
 
 
AC50(5)
 
 
 
EC50(4)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 487    Data Row: 487   Total Pages: 10   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49673088]
Potency 0.259qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Primary screen confirmation [AID2787, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
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2
[SID49673088]
Potency 0.73qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen confirmation [AID2795, Type: confirmatory]glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens] [gi:7669492]
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3
[SID49673088]
Potency 0.73qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen confirmation [AID2795, Type: confirmatory]glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens] [gi:7669492]
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4
[SID49673088]
AC50 2.062HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity [AID493248, Type: confirmatory]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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5
[SID49673088]
Potency 3.2944Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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6
[SID49673088]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID49673088]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID49673088]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID49673088]
Potency 6.3096qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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10
[SID49673088]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID49673088]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID49673088]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID49673088]
Potency 6.7456qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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14
[SID49673088]
Potency 11.2202qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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15
[SID49673088]
Potency 12.5893qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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16
[SID49673088]
IC50 14.289Discovery of Small Molecule Probes for H1N1 Influenza NS1A [AID504329, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/California/07/2009(H1N1))] [gi:227977143]
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17
[SID49673088]
Potency 15.8489qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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18
[SID49673088]
Potency 16.3535qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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19
[SID49673088]
AC50 20.17Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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20
[SID49673088]
Potency 20.5962qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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21
[SID49673088]
Potency 22.3872qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]MEN1 gene product [Homo sapiens] [gi:18860839]
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22
[SID49673088]
IC50 100Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition [AID588689, Type: confirmatory]Chain A, Crystal Structure Of Dengue-2 Virus Methyltransferase Complexed With S-Adenosyl-L-Homocyste [gi:219689243]
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23
[SID49673088]
 Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID540248, Type: other]HTRA1 protein [gi:121945198]
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24
[SID49673088]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID504803, Type: screening]HTRA1 protein [gi:121945198]
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25
[SID49673088]
 Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3) [AID1800, Type: screening]NS3 [Hepatitis C virus] [gi:125541954]
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26
[SID49673088]
 HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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27
[SID49673088]
 Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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28
[SID49673088]
 Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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29
[SID49673088]
 uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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30
[SID49673088]
 Counter screen in the myeloid differentiation screening campaign for compound fluorescence with Cherry Pick01 [AID651707, Type: other]
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31
[SID49673088]
 uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504690, Type: screening]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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32
[SID49673088]
 Counter screen for compounds that modulate transient receptor potential cation channel C6 (TRPC6) [AID488924, Type: screening]
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33
[SID49673088]
 Counter screen for identification of compounds that activate the regulator of G-protein signaling 4 (RGS4): Non-induced cells with the primary screen assay [AID602283, Type: screening]
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34
[SID49673088]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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35
[SID49673088]
 Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_SinglePoint_HTS_Activity [AID651704, Type: screening]MLLT3 gene product [Homo sapiens] [gi:156104889]
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36
[SID49673088]
 Validation assay for identification of compounds that activate the regulator of G-protein signaling 4 (RGS4) [AID602282, Type: screening]RGS4 gene product [Homo sapiens] [gi:5032039]
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37
[SID49673088]
 Validation assay for identification of compounds that activate the regulator of G-protein signaling 4 (RGS4) [AID602282, Type: screening]RGS4 gene product [Homo sapiens] [gi:5032039]
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38
[SID49673088]
 Validation assay for identification of compounds that activate the regulator of G-protein signaling 4 (RGS4) [AID602282, Type: screening]RGS4 gene product [Homo sapiens] [gi:5032039]
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39
[SID49673088]
 Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate regulator of G-protein signaling 4 (RGS4) [AID463111, Type: screening]RGS4 gene product [Homo sapiens] [gi:5032039]
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40
[SID49673088]
 Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate regulator of G-protein signaling 4 (RGS4) [AID463111, Type: screening]RGS4 gene product [Homo sapiens] [gi:5032039]
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41
[SID49673088]
 Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate regulator of G-protein signaling 4 (RGS4) [AID463111, Type: screening]RGS4 gene product [Homo sapiens] [gi:5032039]
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42
[SID49673088]
 Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1). [AID1974, Type: screening]glutathione S-transferase omega-1 isoform 1 [Homo sapiens] [gi:4758484]
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43
[SID49673088]
 Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1). [AID1974, Type: screening]glutathione S-transferase omega-1 isoform 1 [Homo sapiens] [gi:4758484]
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44
[SID49673088]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]PLA2G7 gene product [Homo sapiens] [gi:270133071]
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45
[SID49673088]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]PLA2G7 gene product [Homo sapiens] [gi:270133071]
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46
[SID49673088]
 High throughput screening of inhibitors of transient receptor potential cation channel C6 (TRPC6) [AID2553, Type: screening]short transient receptor potential channel 6 [Mus musculus] [gi:160333370]
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47
[SID49673088]
 Specificity screen against TRPC4 for compounds that modulate transient receptor potential cation channel C6 (TRPC6) [AID488927, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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48
[SID49673088]
 Second specificity screen against TRPC4 for compounds that modulate transient receptor potential cation channel C6 (TRPC6) [AID488928, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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49
[SID49673088]
 Confirmatory screen for identification of compounds that inhibit transient receptor potential cation channel C6 (TRPC6) [AID488960, Type: screening]short transient receptor potential channel 6 [Mus musculus] [gi:160333370]
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50
[SID49673088]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the Epstein-Barr virus nuclear antigen 1 (EBNA-1). [AID1950, Type: screening]EBNA-1 protein [Human herpesvirus 4] [gi:23893623]
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