pinobanksin (CID 73202) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Inactive(25)
 
 
Unspecified(17)
 
 
Top Targets:
Tyrosinase(6)
 
 
Bcl-2 like(1)
 
 
DUF3371(1)
 
 
MSH6 like(1)
 
 
Myc N(1)
 
 
BioAssay Types:
Literature(25)
 
 
 
Screening(17)
 
 
BioActivity Types:
IC50(3)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 42    Data Row: 42   Total Pages: 1   
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103719054]
IC50 100Inhibition of melanogenesis in theophyline-stimulated mouse B16-4A5 cells after 72 hrs [AID450471, Type: Literature]
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2
[SID103719054]
IC50 100Inhibition of theophyline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability after 68 hrs by WST8 assay [AID450477, Type: Literature]
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3
[SID103719054]
IC50 100Inhibition of mushroom tyrosinase [AID450483, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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4
[SID103719054]
 Inhibition of theophyline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability at 1 uM after 68 hrs by WST8 assay [AID450472, Type: Literature]
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5
[SID103719054]
 Inhibition of theophyline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability at 3 uM after 68 hrs by WST8 assay [AID450473, Type: Literature]
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6
[SID103719054]
 Inhibition of theophyline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability at 10 uM after 68 hrs by WST8 assay [AID450474, Type: Literature]
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7
[SID103719054]
 Inhibition of theophyline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability at 30 uM after 68 hrs by WST8 assay [AID450475, Type: Literature]
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8
[SID103719054]
 Inhibition of theophyline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability at 100 uM after 68 hrs by WST8 assay [AID450476, Type: Literature]
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9
[SID103719054]
 Inhibition of melanogenesis in theophyline-stimulated mouse B16-4A5 cells at 10 uM after 72 hrs [AID450468, Type: Literature]
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10
[SID103719054]
 Inhibition of melanogenesis in theophyline-stimulated mouse B16-4A5 cells at 30 uM after 72 hrs [AID450469, Type: Literature]
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11
[SID103719054]
 Inhibition of melanogenesis in theophyline-stimulated mouse B16-4A5 cells at 100 uM after 72 hrs [AID450470, Type: Literature]
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12
[SID103719054]
 Inhibition of mushroom tyrosinase at 1 uM [AID450478, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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13
[SID103719054]
 Inhibition of mushroom tyrosinase at 3 uM [AID450479, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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14
[SID103719054]
 Inhibition of mushroom tyrosinase at 10 uM [AID450480, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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15
[SID103719054]
 Inhibition of mushroom tyrosinase at 30 uM [AID450481, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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16
[SID103719054]
 Inhibition of mushroom tyrosinase at 100 uM [AID450482, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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17
[SID103719054]
 Inhibition of melanogenesis in theophyline-stimulated mouse B16-4A5 cells at 3 uM after 72 hrs [AID450467, Type: Literature]
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18
[SID85843169]
 Luminescence Cell-Based Primary HTS to Identify Re-Activators of the P53 Mutant Pathway Measured in Cell-Based System Using Plate Reader - 2071-01_Activator_SinglePoint_HTS_Activity [AID624151, Type: screening]
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19
[SID85843169]
 Fluorescence Cell-Based Primary HTS to Identify Reactive Oxygen Species Inducers in Cancer Cells Measured in Cell-Based System Using Plate Reader and Imaging Combination - 2044-01_Activator_SinglePoint_HTS_Activity [AID624156, Type: screening]
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20
[SID85843169]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of the Sonic Hedgehog Signaling Pathway [AID2313, Type: screening]
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21
[SID85843169]
 Luminescence Cell-Based Primary HTS to Identify Activators of the Reversal of PD-1 Mediated Inhibitors of T-Cell Inhibition [AID2316, Type: screening]
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22
[SID85843169]
 Luminescence Homogenous Primary HTS to Identify Inhibitors of STK33 Activity [AID2322, Type: screening]
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23
[SID85843169]
 Fluorescence Cell-Based Primary HTS to Measure Inhibition of Y box Binding Protein 1 Expression [AID434959, Type: screening]
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24
[SID85843169]
 Luminescence Cell-Based Primary HTS to Measure Viability of BJeLR cells [AID2275, Type: screening]
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25
[SID103719054]
 Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay [AID469799, Type: Literature]
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26
[SID103719054]
 Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol after 96 hrs by alamar blue assay [AID469800, Type: Literature]
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27
[SID103719054]
 Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol after 96 hrs by alamar blue assay [AID469801, Type: Literature]
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28
[SID103719054]
 Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay [AID469802, Type: Literature]
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29
[SID103719054]
 Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by luciferase reporter gene assay [AID469803, Type: Literature]
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30
[SID103719054]
 Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol by luciferase reporter gene assay [AID469804, Type: Literature]
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31
[SID103719054]
 Estrogenic activity in luciferase transfected human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by luciferase reporter gene assay [AID469805, Type: Literature]
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32
[SID103719054]
 Estrogenic activity in luciferase transfected human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol by luciferase reporter gene assay [AID469806, Type: Literature]
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33
[SID85843169]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of A1 [AID2241, Type: screening]Chain A, Human Bcl2-A1 In Complex With Bim-Bh3 Peptide [gi:167013344]
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34
[SID85843169]
 EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Reader - 2125-01_Inhibitor_SinglePoint_HTS_Activity [AID651548, Type: screening]EZH2 gene product [Homo sapiens] [gi:21361095]
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35
[SID85843169]
 Development of IDH1/2 inhibitors (CTD2project) Measured in Biochemical System Using Plate Reader - 2107-01_Inhibitor_SinglePoint_HTS_Activity [AID624101, Type: screening]Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens] [gi:62203298]
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36
[SID85843169]
 Development of IDH1/2 inhibitors (CTD2project) Measured in Biochemical System Using Plate Reader - 2107-01_Inhibitor_SinglePoint_HTS_Activity [AID624101, Type: screening]Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens] [gi:62203298]
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37
[SID85843169]
 Development of IDH1/2 inhibitors (CTD2project) Measured in Biochemical System Using Plate Reader - 2107-01_Inhibitor_SinglePoint_HTS_Activity [AID624101, Type: screening]Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens] [gi:62203298]
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38
[SID85843169]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of MITF [AID2240, Type: screening]microphthalmia-associated transcription factor isoform 1 [Homo sapiens] [gi:38156699]
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39
[SID85843169]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of MITF [AID2240, Type: screening]microphthalmia-associated transcription factor isoform 1 [Homo sapiens] [gi:38156699]
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40
[SID85843169]
 SMM c-myc Measured in Biochemical System Using Small Molecule MicroArray - 2081-01_Other_SinglePoint_HTS_Activity [AID624141, Type: screening]MYC gene product [Homo sapiens] [gi:71774083]
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41
[SID85843169]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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42
[SID85843169]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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43
[SID85843169]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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44
[SID85843169]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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45
[SID85843169]
 SMM STAT-3 Measured in Biochemical System Using Small Molecule MicroArray - 2076-01_Other_SinglePoint_HTS_Activity_Set2 [AID624138, Type: screening]STAT3 gene product [Homo sapiens] [gi:21618340]
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46
[SID85843169]
 SMM STAT-3 Measured in Biochemical System Using Small Molecule MicroArray - 2076-01_Other_SinglePoint_HTS_Activity_Set2 [AID624138, Type: screening]STAT3 gene product [Homo sapiens] [gi:21618340]
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47
[SID85843169]
 SMM STAT-3 Measured in Biochemical System Using Small Molecule MicroArray - 2076-01_Other_SinglePoint_HTS_Activity_Set2 [AID624138, Type: screening]STAT3 gene product [Homo sapiens] [gi:21618340]
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48
[SID85843169]
 mutant P53 Measured in Biochemical System Using Small Molecule MicroArray - 2077-01_Other_SinglePoint_HTS_Activity [AID624136, Type: screening]mutant p53 [Homo sapiens] [gi:208342286]
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49
[SID85843169]
 mutant P53 Measured in Biochemical System Using Small Molecule MicroArray - 2077-01_Other_SinglePoint_HTS_Activity [AID624136, Type: screening]mutant p53 [Homo sapiens] [gi:208342286]
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50
[SID85843169]
 mutant P53 Measured in Biochemical System Using Small Molecule MicroArray - 2077-01_Other_SinglePoint_HTS_Activity [AID624136, Type: screening]mutant p53 [Homo sapiens] [gi:208342286]
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