MLS000549042 (CID 7303054) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(22)
 
 
Inactive(611)
 
 
Inconclusive(19)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
alkPPc(10)
 
 
Bcl-2 like(10)
 
 
7TM GPCR Srsx(8)
 
 
G-alpha(6)
 
 
 
BioAssay Types:
Screening(440)
 
 
 
 
 
Confirmatory(193)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(135)
 
 
 
 
 
IC50(38)
 
 
 
EC50(12)
 
 
 
AC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 650    Data Row: 654   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14728417]
Potency 0.7943qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
View
2
[SID14728417]
Potency 0.7943qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
View
3
[SID14728417]
EC50 1.8Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]DNA recombination protein RecA [Mycobacterium tuberculosis H37Rv] [gi:15609874]
View
4
[SID14728417]
AC50 3.429Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity [AID449749, Type: confirmatory]replicative DNA helicase [Mycobacterium tuberculosis H37Rv] [gi:15607200]
View
5
[SID14728417]
EC50 3.695Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]DNA recombination protein RecA [Mycobacterium tuberculosis H37Rv] [gi:15609874]
View
6
[SID14728417]
Potency 5.0119qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
View
7
[SID14728417]
Potency 5.0119qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
View
8
[SID14728417]
Potency 5.0119qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
View
9
[SID14728417]
AC50 11.12Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity [AID449750, Type: confirmatory]replicative DNA helicase [Mycobacterium tuberculosis H37Rv] [gi:15607200]
View
10
[SID14728417]
Potency 11.2202VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
11
[SID14728417]
Potency 14.1254qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
View
12
[SID14728417]
Potency 14.1254qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
View
13
[SID14728417]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
14
[SID14728417]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
15
[SID14728417]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
16
[SID14728417]
Potency 29.0929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
17
[SID14728417]
Potency 29.0929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
18
[SID14728417]
Potency 29.0929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
19
[SID14728417]
IC50 100Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition [AID588689, Type: confirmatory]Chain A, Crystal Structure Of Dengue-2 Virus Methyltransferase Complexed With S-Adenosyl-L-Homocyste [gi:219689243]
View
20
[SID14728417]
 Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
View
21
[SID14728417]
 Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
View
22
[SID14728417]
 Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
View
23
[SID14728417]
 Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen [AID598, Type: screening]
View
24
[SID14728417]
 Luminescence-based counterscreen assay for HSP90 inhibitors: biochemical high throughput screening assay to identify inhibitors of native luciferase. [AID1847, Type: screening]
View
25
[SID14728417]
 uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
View
26
[SID14728417]
 Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of RecA Intein Splicing Activity [AID2221, Type: screening]DNA recombination protein RecA [Mycobacterium tuberculosis H37Rv] [gi:15609874]
View
27
[SID14728417]
 Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition by HTS hits of PADs 1-4 [AID588487_4, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
View
28
[SID14728417]
 Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition by HTS hits of PADs 1-4 [AID588487, Type: other]protein-arginine deiminase type-1 [Homo sapiens] [gi:122056685]
View
29
[SID14728417]
 uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) [AID602440, Type: screening]SENP8 gene product [Homo sapiens] [gi:262118306]
View
30
[SID14728417]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) [AID485272, Type: screening]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
View
31
[SID14728417]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) [AID485272, Type: screening]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
View
32
[SID14728417]
 Primary biochemical high-throughput screening assay to measure P97 ATPase inhibition [AID1481, Type: screening]Valosin-containing protein [Homo sapiens] [gi:111305821]
View
33
[SID14728417]
 Primary biochemical high-throughput screening assay to measure P97 ATPase inhibition [AID1481, Type: screening]Valosin-containing protein [Homo sapiens] [gi:111305821]
View
34
[SID14728417]
 Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1). [AID1974, Type: screening]glutathione S-transferase omega-1 isoform 1 [Homo sapiens] [gi:4758484]
View
35
[SID14728417]
 Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1). [AID1974, Type: screening]glutathione S-transferase omega-1 isoform 1 [Homo sapiens] [gi:4758484]
View
36
[SID14728417]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
View
37
[SID14728417]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
View
38
[SID14728417]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
View
39
[SID14728417]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
View
40
[SID14728417]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
View
41
[SID14728417]
Potency 89.1251HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
View
42
[SID14728417]
 uHTS identification of small molecule inhibitors of Csn-mediated Deneddylation of Cullin-Ring Ligases, vis a fluorescence polarization assay [AID651999, Type: screening]COPS5 gene product [Homo sapiens] [gi:38027923]
View
43
[SID14728417]
 Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition by HTS hits of PADs 1-4 [AID588487_2, Type: other]protein-arginine deiminase type-2 [Homo sapiens] [gi:122939159]
View
44
[SID14728417]
 Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition by HTS hits of PADs 1-4 [AID588487_3, Type: other]protein-arginine deiminase type-3 [Homo sapiens] [gi:122939161]
View
45
[SID14728417]
 Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition by HTS hits of PADs 1-4 [AID588487_1, Type: other]protein-arginine deiminase type-1 [Homo sapiens] [gi:122056685]
View
46
[SID14728417]
Potency qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
View
47
[SID14728417]
 Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) [AID624377, Type: screening]ASAP1 gene product [Homo sapiens] [gi:351542238]
View
48
[SID14728417]
 Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID602281, Type: screening]ABHD5 gene product [Homo sapiens] [gi:31542303]
View
49
[SID14728417]
 Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK9 [AID488922, Type: screening]KCNK9 gene product [Homo sapiens] [gi:7706135]
View
50
[SID124843441]
 A screen for small molecule inhibitors of the human deubiquitinating enzyme, UCH37 [AID588478, Type: other]ubiquitin C-terminal hydrolase UCH37 [Homo sapiens] [gi:4877999]
View