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hesperetin (CID 72281) - Compound BioActivity Data
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BioActivity Outcomes:
Active(32)
 
 
Inactive(646)
 
 
Inconclusive(63)
 
 
Unspecified(86)
 
 
Top Targets:
7tm 4(38)
 
 
 
p450(17)
 
 
 
 
NR LBD PPAR(8)
 
 
 
HSD10-like SD..(8)
 
 
 
CASc(6)
 
 
BioAssay Types:
Screening(333)
 
 
 
Confirmatory(296)
 
 
 
 
 
Literature(117)
 
 
 
 
 
BioActivity Types:
Potency(235)
 
 
 
 
 
IC50(26)
 
 
 
 
 
EC50(7)
 
 
Ki(2)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 675    Data Row: 827   Total Pages: 42   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103558713]
IC50 0.511Inhibition of human CYP1B1 by EROD assay [AID502475, Type: Literature]Cytochrome P450 1B1 [gi:48429256]
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2
[SID103558713]
IC50 2.1Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression after 18 hrs [AID400608, Type: Literature]
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3
[SID103558713]
IC50 2.786Inhibition of human CYP1A1 by EROD assay [AID502474, Type: Literature]Cytochrome P450 1A1 [gi:117139]
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4
[SID11112384]
Potency 5.0119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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5
[SID11112384]
Potency 5.0119qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
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6
[SID11112385]
Potency 7.9433qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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7
[SID103558713]
IC50 8.3Inhibition of SARS coronavirus 3C-like protease cis-cleavage activity transfected in african green monkey Vero cells by luciferase reporter gene assay [AID753300, Type: Literature]
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8
[SID11112384]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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9
[SID56463566]
Potency 15.1014qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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10
[SID26754195]
Potency 15.8489qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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11
[SID103558713]
ID50 20.9Inhibition of Moloney murine leukemia virus reverse transcriptase using (riboadenylic acid)n(deoxythymidylic acid)12-18 as template primer by liquid scintillation counting [AID339056, Type: Literature]
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12
[SID103558713]
ID50 22.1Inhibition of Moloney murine leukemia virus reverse transcriptase using (ribocytidylic acid)n(deoxyguanylic acid)12-18 as template primer by liquid scintillation counting [AID339057, Type: Literature]
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13
[SID103558713]
Kd 24.5Binding affinity to SARS coronavirus 3C-like protease by SPR analysis [AID753299, Type: Literature]
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14
[SID103558713]
IC50 26.9Inhibition of Homo sapiens (human) recombinant GSK3beta after 30 min by Kinase-Glo assay [AID1115335, Type: confirmatory]Glycogen synthase kinase-3 beta [gi:20455502]
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15
[SID103558713]
IC50 34.647Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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16
[SID56463566]
Wnt/Beta-catenin HTS Measured in Cell-Based System Using Plate Reader - 2161-01_Activator_SinglePoint_HTS_Activity [AID743398, Type: screening]
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17
[SID103558713]
Antagonist activity at human TGF-beta receptor in HeLa cells assessed as reduction in TGF-beta1-induced Smad3 phosphorylation at 100 uM after 1 hr by Western blot analysis [AID717764, Type: Literature]
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18
[SID103558713]
Antagonist activity at human TGF-beta receptor in HeLa cells assessed as suppression of nuclear translocation of Smad3 at 100 uM after 1 hr by immunofluorescence imaging [AID717765, Type: Literature]
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19
[SID103558713]
Antagonist activity at human TGF-beta receptor in HeLa cells assessed as reduction in TGF-beta1-induced p21 expression at 100 uM after 24 hrs by Western blot analysis [AID717766, Type: Literature]
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20
[SID103558713]
Antimigratory activity against human HeLa cells assessed as inhibition of TGF-beta1-induced cell migration at 100 uM after 24 hrs by scratch motility assay [AID717767, Type: Literature]
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