hesperetin (CID 72281) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(22)
 
 
Inactive(553)
 
 
Inconclusive(59)
 
 
Unspecified(63)
 
 
Top Targets:
p450(18)
 
 
 
 
 
7TM GPCR Srx(17)
 
 
 
NR LBD PPAR(6)
 
 
 
7TM GPCR Srsx(6)
 
 
ampC(6)
 
 
 
BioAssay Types:
Screening(284)
 
 
 
Confirmatory(261)
 
 
 
 
 
Literature(76)
 
 
 
 
 
BioActivity Types:
Potency(204)
 
 
 
 
 
IC50(21)
 
 
 
 
 
EC50(7)
 
 
Ki(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 598    Data Row: 697   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103558713]
IC50 0.511Inhibition of human CYP1B1 by EROD assay [AID502475, Type: Literature]Cytochrome P450 1B1 [gi:48429256]
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2
[SID103558713]
IC50 2.1Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression after 18 hrs [AID400608, Type: Literature]
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3
[SID103558713]
IC50 2.786Inhibition of human CYP1A1 by EROD assay [AID502474, Type: Literature]Cytochrome P450 1A1 [gi:117139]
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4
[SID11112384]
Potency 5.0119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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5
[SID11112384]
Potency 5.0119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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6
[SID11112384]
Potency 5.0119qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
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7
[SID11112384]
Potency 5.0119qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
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8
[SID11112384]
Potency 5.0119qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
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9
[SID11112385]
Potency 7.9433qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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10
[SID11112385]
Potency 7.9433qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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11
[SID11112384]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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12
[SID11112384]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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13
[SID11112384]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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14
[SID56463566]
Potency 15.1014qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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15
[SID26754195]
Potency 15.8489qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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16
[SID26754195]
Potency 15.8489qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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17
[SID26754195]
Potency 15.8489qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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18
[SID103558713]
ID50 20.9Inhibition of Moloney murine leukemia virus reverse transcriptase using (riboadenylic acid)n(deoxythymidylic acid)12-18 as template primer by liquid scintillation counting [AID339056, Type: other]
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19
[SID103558713]
ID50 22.1Inhibition of Moloney murine leukemia virus reverse transcriptase using (ribocytidylic acid)n(deoxyguanylic acid)12-18 as template primer by liquid scintillation counting [AID339057, Type: other]
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20
[SID103558713]
IC50 34.647Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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21
[SID103558713]
IC50 34.647Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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22
[SID103558713]
IC50 34.647Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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23
[SID11112385]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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24
[SID11112385]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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25
[SID11112385]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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26
[SID11112384]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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27
[SID11112384]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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28
[SID11112384]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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29
[SID11112384]
 Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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30
[SID11112384]
 Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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31
[SID11112384]
 Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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32
[SID11112384]
 Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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33
[SID11112384]
 Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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34
[SID11112384]
 Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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35
[SID103558713]
 Induction of PPARgamma-mediated ABCA1 promoter activity in human THP1 cells after 24 hrs by luciferase reporter gene analysis [AID663328, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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36
[SID103558713]
 Induction of PPARgamma-mediated ABCA1 promoter activity in human THP1 cells after 24 hrs by luciferase reporter gene analysis [AID663328, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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37
[SID103558713]
 Induction of PPARgamma-mediated ABCA1 promoter activity in human THP1 cells after 24 hrs by luciferase reporter gene analysis [AID663328, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
38
[SID103558713]
 Induction of PPARgamma-mediated ABCA1 promoter activity in human THP1 cells after 24 hrs by luciferase reporter gene analysis [AID663328, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
39
[SID103558713]
 Induction of LXRalpha-mediated ABCA1 promoter activity in human THP1 cells after 24 hrs by luciferase reporter gene analysis [AID663324, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
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40
[SID103558713]
 Induction of LXRalpha-mediated ABCA1 promoter activity in human THP1 cells after 24 hrs by luciferase reporter gene analysis [AID663324, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
41
[SID103558713]
 Induction of LXRalpha-mediated ABCA1 promoter activity in human THP1 cells after 24 hrs by luciferase reporter gene analysis [AID663324, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
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42
[SID103558713]
 Increase in LXRalpha-mediated ABCA1 mRNA expression in human THP1 cells at 5 to 15 uM after 24 hrs by RT-PCR analysis [AID663325, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
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43
[SID103558713]
 Increase in LXRalpha-mediated ABCA1 mRNA expression in human THP1 cells at 5 to 15 uM after 24 hrs by RT-PCR analysis [AID663325, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
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44
[SID103558713]
 Increase in LXRalpha-mediated ABCA1 mRNA expression in human THP1 cells at 5 to 15 uM after 24 hrs by RT-PCR analysis [AID663325, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
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45
[SID103558713]
 Increase in LXRalpha-mediated ABCA1 protein expression in human THP1 cells at 5 to 15 uM after 48 hrs by Western blotting analysis [AID663326, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
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46
[SID103558713]
 Increase in LXRalpha-mediated ABCA1 protein expression in human THP1 cells at 5 to 15 uM after 48 hrs by Western blotting analysis [AID663326, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
47
[SID103558713]
 Increase in LXRalpha-mediated ABCA1 protein expression in human THP1 cells at 5 to 15 uM after 48 hrs by Western blotting analysis [AID663326, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
48
[SID56463566]
 Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity [AID602393, Type: screening]transcription activator BRG1 isoform 1 [Mus musculus] [gi:291463269]
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49
[SID103558713]
EC50 10Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method [AID477851, Type: Literature]
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50
[SID103558713]
EC50 10Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay [AID477850, Type: Literature]
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