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ubenimex (CID 72172) - Compound BioActivity Data
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BioActivity Outcomes:
Active(102)
 
 
Inactive(427)
 
 
Inconclusive(24)
 
 
Unspecified(400)
 
 
Top Targets:
M1 APN 2(44)
 
 
 
 
7TM GPCR Srx(23)
 
 
 
7TM GPCR Srsx(18)
 
 
 
 
p450(17)
 
 
 
MFS(9)
 
 
BioAssay Types:
Confirmatory(346)
 
 
 
 
 
Literature(205)
 
 
 
 
 
Screening(200)
 
 
BioActivity Types:
IC50(244)
 
 
 
 
 
Potency(189)
 
 
 
 
Ki(16)
 
 
 
EC50(6)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 882    Data Row: 953   Total Pages: 48   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103201243]
IC50 0.0005Inhibition of bovine lens cytosolic leucine aminopeptidase by Dixon plot analysis [AID568369, Type: Literature]Cytosol aminopeptidase [gi:124028614]
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2
[SID103201243]
Ki 0.0005Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis [AID704974, Type: Literature]Aminopeptidase N [gi:449081295]
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3
[SID103201243]
Ki 0.0006Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidney [AID101207, Type: Literature]
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4
[SID103201243]
IC50 0.0016Inhibition of Aeromonas proteolytica aminopeptidase by Dixon plot analysis [AID568371, Type: Literature]
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5
[SID103201243]
IC50 0.005Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate [AID35686, Type: Literature]
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6
[SID103201243]
IC50 0.008Antimalarial activity against Plasmodium falciparum 3D7 infected in human O positive erythrocytes under low oxygen atmosphere after 72 hrs by spectrophotometric analysis [AID711161, Type: Literature]
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7
[SID103201243]
Ki 0.014Inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver [AID38221, Type: Literature]
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8
[SID46393277]
Ki 0.018Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, X-Ray Crystal Structure Of Bestatin Bound To Aap [gi:51247772]
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9
[SID46393277]
Ki 0.018Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, X-Ray Crystal Structure Of Bestatin Bound To Aap [gi:51247772]
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10
[SID103201243]
Ki 0.02Inhibitory activity against Leucine aminopeptidase [AID101204, Type: Literature]
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11
[SID103201243]
Ki 0.02Inhibition of leucine aminopeptidase [AID101332, Type: Literature]
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12
[SID103201243]
Ki 0.06Inhibitory activity against aminopeptidase B [AID38222, Type: Literature]
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13
[SID103201243]
IC50 0.17Inhibition of partially purified soluble aminopeptidase from rat brain [AID35689, Type: Literature]
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14
[SID103201243]
Ki 0.19Inhibition of Plasmodium falciparum recombinant M1-aminopeptidase expressed in Escherichia coli after 40 mins uisng fluorogenic substrate L-Leucyl-7-amido-40-methylcoumarin by fluorescence spectrophotometry [AID587097, Type: Literature]
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15
[SID103201243]
IC50 0.284Inhibitory activity for Plasmodium falciparum Zinc aminopeptidase [AID220436, Type: Literature]
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16
[SID103201243]
IC50 0.3Compound was evaluated for its inhibitory potency against purified membrane bound rat brain APs [AID35664, Type: Literature]
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17
[SID103201243]
IC50 0.478Inhibition of Plasmodium falciparum recombinant AM1 using Leu-pNA as substrate [AID711021, Type: Literature]
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18
[SID103201243]
IC50 0.5Inhibition of aminopeptidase activity of human leukotriene A4 hydrolase by Dixon plot analysis [AID568370, Type: Literature]Leukotriene A-4 hydrolase [gi:126353]
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19
[SID103201243]
Ki 0.5Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis [AID704972, Type: Literature]Cytosol aminopeptidase [gi:124028614]
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20
[SID103201243]
EC50 0.9Antimalarial activity as inhibition of Plasmodium falciparum 3D7 replication in medium + isoleucine after 65 hrs [AID386437, Type: Literature]
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