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ubenimex (CID 72172) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(87)
 
 
Inactive(422)
 
 
Inconclusive(24)
 
 
Unspecified(230)
 
 
Top Targets:
M1 APN 2(37)
 
 
 
 
7TM GPCR Srx(23)
 
 
 
7TM GPCR Srsx(18)
 
 
 
 
p450(17)
 
 
 
MFS(9)
 
 
BioAssay Types:
Confirmatory(217)
 
 
 
 
Screening(200)
 
 
Literature(172)
 
 
 
 
 
BioActivity Types:
IC50(229)
 
 
 
 
 
Potency(184)
 
 
 
 
Ki(14)
 
 
 
EC50(6)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 697    Data Row: 763   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103201243]
IC50 0.0005Inhibition of bovine lens cytosolic leucine aminopeptidase by Dixon plot analysis [AID568369, Type: Literature]Cytosol aminopeptidase [gi:124028614]
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2
[SID103201243]
Ki 0.0005Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis [AID704974, Type: Literature]Aminopeptidase N [gi:449081295]
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3
[SID103201243]
Ki 0.0006Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidney [AID101207, Type: Literature]
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4
[SID103201243]
IC50 0.0016Inhibition of Aeromonas proteolytica aminopeptidase by Dixon plot analysis [AID568371, Type: Literature]
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5
[SID103201243]
IC50 0.005Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate [AID35686, Type: Literature]
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6
[SID103201243]
IC50 0.008Antimalarial activity against Plasmodium falciparum 3D7 infected in human O positive erythrocytes under low oxygen atmosphere after 72 hrs by spectrophotometric analysis [AID711161, Type: Literature]
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7
[SID103201243]
Ki 0.014Inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver [AID38221, Type: Literature]
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8
[SID103201243]
Ki 0.02Inhibition of leucine aminopeptidase [AID101332, Type: Literature]
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9
[SID103201243]
Ki 0.02Inhibitory activity against Leucine aminopeptidase [AID101204, Type: Literature]
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10
[SID103201243]
Ki 0.06Inhibitory activity against aminopeptidase B [AID38222, Type: Literature]
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11
[SID103201243]
IC50 0.17Inhibition of partially purified soluble aminopeptidase from rat brain [AID35689, Type: Literature]
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12
[SID103201243]
Ki 0.19Inhibition of Plasmodium falciparum recombinant M1-aminopeptidase expressed in Escherichia coli after 40 mins uisng fluorigenic substrate L-Leucyl-7-amido-40-methylcoumarin by fluorescence spectrophotometry [AID587097, Type: Literature]
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13
[SID103201243]
IC50 0.284Inhibitory activity for Plasmodium falciparum Zinc aminopeptidase [AID220436, Type: Literature]
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14
[SID103201243]
IC50 0.3Compound was evaluated for its inhibitory potency against purified membrane bound rat brain APs [AID35664, Type: Literature]
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15
[SID103201243]
IC50 0.478Inhibition of Plasmodium falciparum recombinant AM1 using Leu-pNA as substrate [AID711021, Type: Literature]
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16
[SID103201243]
Ki 0.5Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis [AID704972, Type: Literature]Cytosol aminopeptidase [gi:124028614]
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17
[SID103201243]
IC50 0.5Inhibition of aminopeptidase activity of human leukotriene A4 hydrolase by Dixon plot analysis [AID568370, Type: Literature]Leukotriene A-4 hydrolase [gi:126353]
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18
[SID103201243]
EC50 0.9Antimalarial activity as inhibition of Plasmodium falciparum 3D7 replication in medium + isoleucine after 65 hrs [AID386437, Type: Literature]
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19
[SID103201243]
EC50 1.8Antimalarial activity as inhibition of Plasmodium falciparum 3D7 replication in medium with all amino acids after 65 hrs [AID386438, Type: Literature]
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20
[SID103201243]
IC50 2.1Inhibition of pig kidney aminopeptidase N [AID406526, Type: Literature]Aminopeptidase N [gi:449081295]
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21
[SID103201243]
IC50 2.1Inhibition of pig kidney aminopeptidase N using Leu-AMC as substrate [AID472434, Type: Literature]Aminopeptidase N [gi:449081295]
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22
[SID103201243]
IC50 2.4Inhibition of pig kidney microsomes aminopeptidase N preincubated for 30 mins [AID440776, Type: Literature]Aminopeptidase N [gi:449081295]
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23
[SID103201243]
IC50 2.4Inhibition of aminopeptidase N [AID477788, Type: Literature]
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24
[SID103201243]
IC50 2.4Inhibition of pig kidney microsomal aminopeptidase assessed as liberation of p-nitroanilide [AID307411, Type: Literature]Aminopeptidase N [gi:449081295]
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25
[SID103201243]
IC50 2.7Inhibition of microsomal neural aminopeptidase in pig kidney [AID284233, Type: Literature]Aminopeptidase N [gi:449081295]
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26
[SID103201243]
IC50 2.7Inhibitory activity against mammalian Aminopeptidase N (APN) [AID38378, Type: Literature]
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27
[SID103201243]
IC50 3Inhibition of pig kidney microsomal Aminopeptidase N [AID397940, Type: Literature]Aminopeptidase N [gi:449081295]
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28
[SID103201243]
Ki 3.03Inhibition of mouse APN [AID712132, Type: other]Aminopeptidase N [gi:31077182]
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29
[SID103201243]
IC50 3.1Inhibition of pig kidney microsome aminopeptidase N by UV-visible spectrophotometer [AID389009, Type: Literature]Aminopeptidase N [gi:449081295]
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30
[SID103201243]
IC50 3.1Inhibition of pig kidney microsomal APN [AID414664, Type: Literature]Aminopeptidase N [gi:449081295]
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31
[SID103201243]
IC50 3.2Antimalarial activity against Plasmodium falciparum 3D7 infected-erythrocytes after 72 hrs by SYBR green fluorescence method [AID587099, Type: Literature]
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32
[SID103201243]
IC50 3.4Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by spectrophotometric analysis [AID729523, Type: Literature]Aminopeptidase N [gi:449081295]
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33
[SID103201243]
IC50 3.4Inhibition of MMP2 after 30 mins [AID307412, Type: Literature]
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34
[SID103201243]
IC50 3.5Inhibition of human aminopeptidase N by Dixon plot analysis [AID568368, Type: Literature]Aminopeptidase N [gi:143811362]
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35
[SID103201243]
IC50 3.6Inhibition of porcine kidney microsome APN assessed as L-Leu-p-nitroanilide hydrolysis [AID453298, Type: Literature]Aminopeptidase N [gi:449081295]
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36
[SID103201243]
IC50 3.7Inhibition of pig kidney microsomal APN assessed as hydrolysis of L-Leu-p-nitroanilide after 1 hr by spectrophotometry [AID613977, Type: Literature]Aminopeptidase N [gi:449081295]
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37
[SID103201243]
Ki 3.73Inhibition of porcine kidney microsome aminopeptidase using L-Leu-p-nitroanilide as substrate by Dixon method [AID701437, Type: Literature]Aminopeptidase N [gi:449081295]
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38
[SID103201243]
IC50 3.8Inhibition of aminopeptidase N in pig kidney misrosome by spectrophotometry [AID437269, Type: Literature]Aminopeptidase N [gi:449081295]
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39
[SID103201243]
IC50 3.8Inhibition of APN from pig kidney microsomes by spectrophotometry [AID456586, Type: Literature]Aminopeptidase N [gi:449081295]
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40
[SID103201243]
IC50 3.9Inhibitory concentration against aminopeptidase N [AID241143, Type: Literature]Aminopeptidase N [gi:143811362]
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41
[SID103201243]
IC50 4Inhibitory activity against Leukotriene A4 hydrolase from human leukocytes [AID99743, Type: other]Leukotriene A-4 hydrolase [gi:126353]
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42
[SID103201243]
IC50 4Inhibition of human recombinant leukotriene A4 hydrolase [AID362195, Type: Literature]Leukotriene A-4 hydrolase [gi:126353]
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43
[SID103201243]
IC50 4.18Inhibition of pig kidney microsome aminopeptidase N after 30 mins by UV-vis spectrophotometric analysis [AID497182, Type: Literature]Aminopeptidase N [gi:449081295]
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44
[SID103201243]
IC50 4.2Inhibition of human LTA4H epoxide hydrolase activity using LTA4 as substrate incubated for 15 mins prior to substrate addition measured after 10 mins by ELISA [AID724223, Type: Literature]Leukotriene A-4 hydrolase [gi:126353]
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45
[SID103201243]
Ki 4.4Inhibition of aminopeptidase M or membrane leucine aminopeptidase [AID38354, Type: Literature]
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46
[SID103201243]
IC50 4.41Competitive inhibition of pig kidney LAP activity using DCDHF-Leu as substrate after 10 mins by Michealis-Menton equation [AID590644, Type: Literature]
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47
[SID103201243]
EC50 5.1Antimalarial activity against Plasmodium falciparum Dd2 [AID278818, Type: Literature]
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48
[SID103201243]
IC50 5.55Inhibition of pig kidney microsome aminopeptidase N using L-Leu-p-nitroanilide substrate [AID619825, Type: Literature]Aminopeptidase N [gi:449081295]
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49
[SID103201243]
IC50 5.87Inhibition of porcine kidney microsomal APN after 10 mins at room temperature by spectrophtotmetry [AID551696, Type: Literature]Aminopeptidase N [gi:449081295]
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50
[SID103201243]
IC50 6Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method. [AID38206, Type: other]
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