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protocatechuic acid (CID 72) - Compound BioActivity Data
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BioActivity Outcomes:
Active(36)
 
 
Inactive(693)
 
 
Inconclusive(24)
 
 
Unspecified(74)
 
 
Top Targets:
7TM GPCR Srx(22)
 
 
7TM GPCR Srsx(17)
 
 
NR LBD ER(9)
 
 
 
NR LBD PPAR(8)
 
 
 
NR LBD AR(7)
 
 
BioAssay Types:
Screening(423)
 
 
 
 
Confirmatory(247)
 
 
 
 
 
Literature(115)
 
 
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(215)
 
 
 
 
 
IC50(46)
 
 
 
 
 
Ki(13)
 
 
 
EC50(8)
 
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 772    Data Row: 827   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103211071]
Ki 0.47Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID568363, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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2
[SID26665736]
IC50 0.4794QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID2195, Type: confirmatory]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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3
[SID103211071]
Ki 0.69Inhibition of human carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID729533, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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4
[SID103211071]
Ki 1.08Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID568362, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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5
[SID103211071]
Ki 2.45Inhibition of human CA4 using 4NPA as substrate for 3 mins by Lineweaver burk plot analysis [AID667535, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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6
[SID103211071]
EC50 2.56Antioxidant activity assessed as protection against peroxyl radical-induced alkaline phosphatase activity loss by microplate assay [AID425006, Type: Literature]
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7
[SID103211071]
Ki 3.21Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assay [AID607497, Type: Literature]Carbonic anhydrase [gi:123910379]
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8
[SID103211071]
IC50 3.31Antioxidant activity assessed as superoxide anion radical scavenging activity [AID311581, Type: Literature]
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9
[SID103211071]
Ki 4.09Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID568365, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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10
[SID103211071]
Ki 4.45Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID568364, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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11
[SID103211071]
Ki 4.72Inhibition of human CA6 using 4NPA as substrate for 3 mins by Lineweaver burk plot analysis [AID667536, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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12
[SID103211071]
Ki 4.72Inhibition of human CA6 using 4-nitrophenylacetate substrate by esterase assay [AID607496, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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13
[SID26665736]
Potency 5.0119qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen [AID2100, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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14
[SID103211071]
Ki 7.87Inhibition of human carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID729536, Type: Literature]Carbonic anhydrase 7 [gi:1168744]
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15
[SID103211071]
Ki 12Inhibition constant against 1A dihydroate dehydrogenase (1A DHOD) from Lactococcus lactis [AID55861, Type: Literature]
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16
[SID103211071]
IC50 15.7ABTS radical scavenging activity [AID276002, Type: Literature]
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17
[SID103211071]
Kd 19Dissociation constant against 1A dihydroate dehydrogenase (1A DHOD) from Lactococcus lactis at 25 degrees C pH 8.0 [AID55747, Type: Literature]
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18
[SID26665736]
Potency 25.1189qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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19
[SID103211071]
IC50 27DPPH radical scavenging activity [AID276004, Type: Literature]
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20
[SID103211071]
Ki 44Inhibition constant for binding to Co2+ form of 3-dehydroquinate synthase (DHQ) purified from Escherichia coli [AID3249, Type: Literature]
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21
[SID103211071]
Antioxidant activity against Cu2+-induced lipid peroxidation in human plasma LDL at 0.01 to 0.1 umol/L preincubated for 1 hr before Cu2+ challenge [AID397159, Type: Literature]
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22
[SID103211071]
Antioxidant activity against AAPH-induced lipid peroxidation in human plasma LDL at 0.01 to 0.1 umol/L preincubated for 1 hr before AAPH challenge [AID397160, Type: Literature]
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23
[SID103211071]
Antiplatelet activity against rat platelet rich plasma assessed as inhibition of arachidonic acid-induced platelet aggregation at 0.5 mg/ml pretreated 2 mins before arachidonic acid challenge [AID338333, Type: Literature]
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24
[SID103211071]
Antiplatelet activity against rat platelet rich plasma assessed as inhibition of collagen-induced platelet aggregation at 0.25 mg/ml pretreated 2 mins before collagen challenge [AID338336, Type: Literature]
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25
[SID103211071]
Antiplatelet activity against rat platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation at 1 mg/ml pretreated 2 mins before ADP challenge [AID338339, Type: Literature]
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26
[SID103211071]
Antioxidant activity assessed as DPPH radical scavenging activity [AID311580, Type: Literature]
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27
[SID103211071]
Antimelanogenic activity in mouse B16 cells assessed as decrease in tyrosinase expression at 20 ug/ml after 72 hrs by western blotting [AID546250, Type: Literature]
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28
[SID103211071]
Antimelanogenic activity in mouse B16 cells assessed as decrease in TRP2 expression at 20 ug/ml after 72 hrs by western blotting [AID546251, Type: Literature]
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29
[SID103211071]
Antimelanogenic activity in mouse B16 cells assessed as decrease in TRP1 expression at 20 ug/ml after 72 hrs by western blotting [AID546252, Type: Literature]
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30
[SID103211071]
Antimelanogenic activity in mouse B16 cells assessed as decrease in MC1R expression at 20 ug/ml after 72 hrs by western blotting [AID549282, Type: Literature]
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31
[SID103211071]
Antimelanogenic activity in mouse B16 cells assessed as decrease in MITF expression at 20 ug/ml after 72 hrs by western blotting [AID549283, Type: Literature]
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32
[SID26665736]
QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID1822, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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33
[SID26665736]
HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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34
[SID26665736]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the Galanin Receptor 3 (GalR3) [AID651719, Type: screening]galanin receptor type 3 [Homo sapiens] [gi:4503907]
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35
[SID26665736]
QFRET-based biochemical high throughput confirmation assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID2170, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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36
[SID87693008]
Late stage assay provider results from the probe development effort to identify inhibitors of the Plasmodium falciparum M18 Alanyl Aminopeptidase (PfM18AAP): fluorescence-based biochemical assay to identify inhibitors of malaria cell lysate [AID492975, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:124507185]
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37
[SID103211071]
Ki 65Inhibition constant for binding to Zn2+ form of 3-dehydroquinate synthase (DHQ) purified from Escherichia coli [AID3250, Type: Literature]
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38
[SID103211071]
IC50 100Superoxide anion radical scavenging activity by xanthine/xanthine oxidase method [AID276003, Type: Literature]
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39
[SID103211071]
IC50 300Inhibition of CMG2 (40 to 217) C175A and R40C double mutant (unknown origin) interaction to full length PA E733C mutant expressed in Escherichia coli by FRET assay [AID725981, Type: Literature]
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40
[SID103211071]
MIC 649.35Antitubercular activity against Mycobacterium tuberculosis 90-221387 [AID403754, Type: Literature]
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41
[SID103211071]
IC50 29500Inhibition of pieris rapae Phenoloxidase [AID293934, Type: Literature]
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42
[SID103211071]
EC50 140000DPPH radical scavenging activity [AID276460, Type: Literature]
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43
[SID103211071]
Inhibitory activity against family of dihydroorotate dehydrogenase 1A (1A DHOD) from Lactococcus lactis at 1 uMolar concentration [AID55746, Type: Literature]
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44
[SID103211071]
DPPH radical scavenging activity assessed as ratio of antioxidant concentration to drug level causing 50% decrease in DPPH level at steady state at 100 ug by TLC autographic assay [AID425005, Type: Literature]
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45
[SID103211071]
IC50 Inhibition of cataracted human eye lens aldose reductase [AID388742, Type: Literature]Aldose reductase [gi:113596]
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46
[SID103211071]
Antioxidant activity assessed as DPPH radical scavenging activity at 0.1 mg/mL [AID400524, Type: Literature]
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47
[SID103211071]
Antioxidant activity assessed as DPPH radical scavenging activity after 20 mins [AID388743, Type: Literature]
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48
[SID103211071]
Antioxidant activity against Cu2+-induced lipid peroxidation in human plasma LDL at 0.2 umol/L preincubated for 1 hr before Cu2+ challenge [AID397155, Type: Literature]
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49
[SID103211071]
Antioxidant activity against Cu2+-induced lipid peroxidation in human plasma LDL at 1 umol/L preincubated for 1 hr before Cu2+ challenge [AID397156, Type: Literature]
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50
[SID103211071]
Inhibition of human recombinant MMP1 at 1 mM after 30 mins [AID566702, Type: Literature]Interstitial collagenase [gi:116852]
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