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BioActivity Data for Compound protocatechuic acid (CID 72)

BioActivity Outcomes:
Active(45)
 
 
Inactive(741)
 
 
Inconclusive(24)
 
 
Unspecified(103)
 
 
Top Targets:
7tm 4(40)
 
 
NR LBD ER(9)
 
 
 
NR LBD PPAR(8)
 
 
 
NR LBD AR(7)
 
 
G-alpha(7)
 
 
 
BioAssay Types:
Screening(424)
 
 
 
 
Confirmatory(258)
 
 
 
 
 
Literature(181)
 
 
 
 
 
Summary(29)
 
 
 
BioAssay Categories:
In vivo(2)
 
 
Biochemical(176)
 
 
 
 
 
Toxicity(21)
 
 
 
ADME(5)
 
 
 
Cell-based(157)
 
 
 
 
 
Organism-base..(13)
 
 
BioActivity Types:
Potency(231)
 
 
 
 
 
IC50(47)
 
 
 
 
 
Ki(13)
 
 
 
EC50(11)
 
 
 
 
Kd(9)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 847    Data Row: 913   Total Pages: 46   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103211071]
Ki 0.47Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID568363, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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2
[SID26665736]
IC50 0.4794QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID2195, Type: confirmatory]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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3
[SID208013413]
Kd 0.67Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]
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4
[SID208013413]
Kd 0.67Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]
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5
[SID103211071]
Ki 0.69Inhibition of human carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID729533, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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6
[SID103211071]
Ki 1.08Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID568362, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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7
[SID103211071]
Ki 2.45Inhibition of human CA4 using 4NPA as substrate for 3 mins by Lineweaver burk plot analysis [AID667535, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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8
[SID103211071]
EC50 2.56Antioxidant activity assessed as protection against peroxyl radical-induced alkaline phosphatase activity loss by microplate assay [AID425006, Type: Literature]
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9
[SID103211071]
Ki 3.21Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assay [AID607497, Type: Literature] [gi:123910379]
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10
[SID103211071]
IC50 3.31Antioxidant activity assessed as superoxide anion radical scavenging activity [AID311581, Type: Literature]
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11
[SID103211071]
Ki 4.09Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID568365, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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12
[SID103211071]
Ki 4.45Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID568364, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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13
[SID103211071]
Ki 4.72Inhibition of human CA6 using 4NPA as substrate for 3 mins by Lineweaver burk plot analysis [AID667536, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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14
[SID103211071]
Ki 4.72Inhibition of human CA6 using 4-nitrophenylacetate substrate by esterase assay [AID607496, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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15
[SID26665736]
Potency 5.0119qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen [AID2100, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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16
[SID103211071]
Ki 7.87Inhibition of human carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID729536, Type: Literature]Carbonic anhydrase 7 [gi:1168744]
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17
[SID103211071]
EC50 8.83Antioxidant activity assessed as DPPH radical scavenging activity by spectrophotometry [AID1126662, Type: Literature]
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18
[SID103211071]
Ki 12Inhibition constant against 1A dihydroate dehydrogenase (1A DHOD) from Lactococcus lactis [AID55861, Type: Literature]
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19
[SID103211071]
IC50 15.7ABTS radical scavenging activity [AID276002, Type: Literature]
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20
[SID103211071]
Kd 19Dissociation constant against 1A dihydroate dehydrogenase (1A DHOD) from Lactococcus lactis at 25 degrees C pH 8.0 [AID55747, Type: Literature]
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