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CHEMBL2347963 (CID 71571535) - Compound BioActivity Data
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BioActivity Outcomes:
Active(2)
 
 
Unspecified(9)
 
 
Top Targets:
PTKc EGFR(3)
 
 
 
PTKc Jak1 rpt..(1)
 
 
STKc CDK2 3(1)
 
 
BioAssay Types:
Literature(11)
 
 
 
BioActivity Types:
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 11    Data Row: 11   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID164149848]
IC50 0.002Inhibition of human GST-tagged EGFR L834R mutant expressed in Sf9 cells by luminescence assay [AID739694, Type: Literature]
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2
[SID164149848]
IC50 0.008Inhibition of human wild type GST-tagged EGFR kinase domain expressed in Sf9 cells by luminescence assay [AID739693, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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3
[SID164149848]
Inhibition of CDK2 (unknown origin) at 1 uM relative to control [AID739425, Type: Literature]Cyclin-dependent kinase 2 [gi:116051]
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4
[SID164149848]
Inhibition of JAK1 (unknown origin) at 1 uM relative to control [AID739426, Type: Literature]Tyrosine-protein kinase JAK1 [gi:215274013]
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5
[SID164149848]
Inhibition of EGFR T766M mutant (unknown origin) at 1 uM relative to control [AID739427, Type: Literature]
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6
[SID164149848]
Inhibition of EGFR T766M/L834R mutant (unknown origin) at 1 uM relative to control [AID739428, Type: Literature]
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7
[SID164149848]
Inhibition of EGFR L837Q mutant (unknown origin) at 1 uM relative to control [AID739429, Type: Literature]
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8
[SID164149848]
Inhibition of wild type EGFR (unknown origin) at 1 uM relative to control [AID739430, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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9
[SID164149848]
Inhibition of EGFR L834R mutant (unknown origin) at 1 uM relative to control [AID739690, Type: Literature]
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10
[SID164149848]
Ratio of gefitinib IC50 to compound IC50 for human GST-tagged EGFR L834R mutant [AID739691, Type: Literature]
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11
[SID164149848]
Ratio of gefitinib IC50 to compound IC50 for human wild type GST-tagged EGFR kinase domain [AID739692, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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