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CHEMBL2204739 (CID 71457605) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Unspecified(1)
 
 
Top Targets:
renin like(5)
 
 
 
BioAssay Types:
Literature(5)
 
 
 
BioActivity Types:
IC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 5    Data Row: 5   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID163328899]
IC50 0.0016Inhibition of recombinant human renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg as substrate incubated for 10 mins prior to substrate addition measured after 90 mins by fluorimetric analysis [AID717518, Type: Literature]Renin [gi:132326]
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2
[SID163328899]
IC50 0.0016Inhibition of trypsin-activated human recombinant renin using (Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg) as substrate incubated for 10 mins prior to substrate addition measured after 90 mins by fluorescence assay [AID766000, Type: Literature]Renin [gi:132326]
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3
[SID163328899]
IC50 0.01Inhibition of renin in cynomolgus monkey plasma after 60 mins by competitive radioimmunoassay [AID717517, Type: Literature]Renin [gi:62287423]
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4
[SID163328899]
IC50 0.01Inhibition of cynomolgus monkey plasma renin assessed as angiotensin 1 level after 60 mins by competitive radioimmunoassay [AID765999, Type: Literature]Renin [gi:62287423]
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5
[SID163328899]
Ratio of compound IC50 to Aliskiren hemifumarate IC50 for cynomolgus monkey plasma renin [AID765966, Type: Literature]Renin [gi:62287423]
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