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CHEMBL2203705 (CID 71457524) - Compound BioActivity Data
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BioActivity Outcomes:
Active(9)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(2)
 
 
BioAssay Types:
Literature(10)
 
 
 
BioActivity Types:
Ki(4)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 10    Data Row: 10   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID163328776]
Ki 0.0006Displacement of radioligand [3H]osanetant at human NK3 Y315F6.51 mutant expressed in HEK293 cells [AID715705, Type: Literature]
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2
[SID163328776]
Ki 0.0014Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells [AID715708, Type: Literature]Substance-P receptor [gi:128359]
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3
[SID163328776]
Ki 0.0015Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cells [AID715706, Type: Literature]Neuromedin-K receptor [gi:128364]
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4
[SID163328776]
Ki 0.0028Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells [AID715707, Type: Literature]
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5
[SID163328776]
Kd 0.03981Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins [AID715899, Type: Literature]
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6
[SID163328776]
Noncompetitive inhibition at human NK3 Y315F6.51 mutant expressed in HEK293 cells assessed as decrease in [MePhe7]NKB-induced [3H]IP accumulation after 20 mins [AID715713, Type: Literature]
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7
[SID163328776]
Noncompetitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins [AID715901, Type: Literature]Substance-P receptor [gi:128359]
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8
[SID163328776]
Noncompetitive inhibition at wild type human NK3 expressed in HEK293 cells assessed as decrease in [MePhe7]NKB-induced [3H]IP accumulation after 20 mins [AID715714, Type: Literature]Neuromedin-K receptor [gi:128364]
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9
[SID163328776]
Antagonist activity at human NK3 Y315F6.51 mutant expressed in HEK293 cells assessed as decrease in [MePhe7]NKB-induced [3H]IP accumulation at 10 nM after 20 mins [AID715703, Type: Literature]
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10
[SID163328776]
Selectivity ratio of Ki for wild type human NK3 receptor expressed in HEK293 cells to Ki for human NK3 Y315F6.51 mutant expressed in HEK293 cells [AID715704, Type: Literature]
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