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CHEMBL2203706 (CID 71453994) - Compound BioActivity Data
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BioActivity Outcomes:
Active(8)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(2)
 
 
BioAssay Types:
Literature(9)
 
 
 
BioActivity Types:
Ki(4)
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 9    Data Row: 9   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID163321944]
Ki 0.0013Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells [AID715708, Type: Literature]Substance-P receptor [gi:128359]
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2
[SID163321944]
Ki 0.0021Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells [AID715707, Type: Literature]
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3
[SID163321944]
Ki 0.0025Displacement of radioligand [3H]osanetant at human NK3 Y315F6.51 mutant expressed in HEK293 cells [AID715705, Type: Literature]
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4
[SID163321944]
Ki 0.0119Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cells [AID715706, Type: Literature]Neuromedin-K receptor [gi:128364]
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5
[SID163321944]
Kd 0.02089Competitive inhibition at human NK3 Y315F6.51 mutant expressed in HEK293 cells assessed as decrease in [MePhe7]NKB-induced [3H]IP accumulation after 20 mins [AID715715, Type: Literature]
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6
[SID163321944]
Kd 0.12023Competitive inhibition at wild type human NK3 expressed in HEK293 cells assessed as decrease in [MePhe7]NKB-induced [3H]IP accumulation after 20 mins [AID715716, Type: Literature]Neuromedin-K receptor [gi:128364]
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7
[SID163321944]
Noncompetitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins [AID715901, Type: Literature]Substance-P receptor [gi:128359]
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8
[SID163321944]
Noncompetitive inhibition of human NK1 F264Y6.51 mutant receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins [AID715900, Type: Literature]
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9
[SID163321944]
Selectivity ratio of Ki for wild type human NK3 receptor expressed in HEK293 cells to Ki for human NK3 Y315F6.51 mutant expressed in HEK293 cells [AID715704, Type: Literature]
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