dofetilide (CID 71329) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(27)
 
 
Inactive(410)
 
 
Inconclusive(8)
 
 
Unspecified(154)
 
 
Top Targets:
CAP ED(13)
 
 
 
 
7TM GPCR Srx(10)
 
 
alkPPc(10)
 
 
Bcl-2 like(10)
 
 
 
NR LBD PPAR(6)
 
 
BioAssay Types:
Literature(237)
 
 
 
 
 
Screening(208)
 
 
 
 
Confirmatory(135)
 
 
 
BioActivity Types:
Potency(88)
 
 
 
IC50(45)
 
 
 
 
EC50(8)
 
 
Ki(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 516    Data Row: 599   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103168841]
Ki 0.0064Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPA [AID290939, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
2
[SID103168841]
Ki 0.0064Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPA [AID290939, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
3
[SID103168841]
Ki 0.0064Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPA [AID290939, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
4
[SID103168841]
Ki 0.0064Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPA [AID290939, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
5
[SID103168841]
Ki 0.0064Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPA [AID290939, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
6
[SID103168841]
Ki 0.0077Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assay [AID290940, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
7
[SID103168841]
Ki 0.0077Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assay [AID290940, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
8
[SID103168841]
Ki 0.0077Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assay [AID290940, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
9
[SID103168841]
Ki 0.0077Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assay [AID290940, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
10
[SID103168841]
Ki 0.0077Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assay [AID290940, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
11
[SID103168841]
IC50 0.0092Blockade of hERG expressed in HEK293 cells by whole-cell patch clamp method [AID290942, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
12
[SID103168841]
IC50 0.0092Blockade of hERG expressed in HEK293 cells by whole-cell patch clamp method [AID290942, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
13
[SID103168841]
IC50 0.0092Blockade of hERG expressed in HEK293 cells by whole-cell patch clamp method [AID290942, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
14
[SID103168841]
IC50 0.0092Blockade of hERG expressed in HEK293 cells by whole-cell patch clamp method [AID290942, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
15
[SID103168841]
IC50 0.0092Blockade of hERG expressed in HEK293 cells by whole-cell patch clamp method [AID290942, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
16
[SID103168841]
IC50 0.01Inhibitory concentration against potassium channel HERG [AID243151, Type: Literature]
View
17
[SID103168841]
IC50 0.01Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique [AID408340, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
18
[SID103168841]
IC50 0.01Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique [AID408340, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
19
[SID103168841]
IC50 0.01Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique [AID408340, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
20
[SID103168841]
IC50 0.01Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique [AID408340, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
21
[SID103168841]
IC50 0.01Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique [AID408340, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
22
[SID103168841]
IC50 0.01Inhibition of human Potassium channel HERG expressed in mammalian cells [AID161281, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
23
[SID103168841]
IC50 0.01Inhibition of human Potassium channel HERG expressed in mammalian cells [AID161281, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
24
[SID103168841]
IC50 0.01Inhibition of human Potassium channel HERG expressed in mammalian cells [AID161281, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
25
[SID103168841]
IC50 0.01Inhibition of human Potassium channel HERG expressed in mammalian cells [AID161281, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
26
[SID103168841]
IC50 0.01Inhibition of human Potassium channel HERG expressed in mammalian cells [AID161281, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
27
[SID103168841]
IC50 0.01Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1 [AID161283, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
28
[SID103168841]
IC50 0.01Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1 [AID161283, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
29
[SID103168841]
IC50 0.01Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1 [AID161283, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
30
[SID103168841]
IC50 0.01Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1 [AID161283, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
31
[SID103168841]
IC50 0.01Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1 [AID161283, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
32
[SID103168841]
IC50 0.0123Inhibition of human ERG in MCF7 cells [AID420668, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
33
[SID103168841]
IC50 0.0123Inhibition of human ERG in MCF7 cells [AID420668, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
34
[SID103168841]
IC50 0.0123Inhibition of human ERG in MCF7 cells [AID420668, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
35
[SID103168841]
IC50 0.0123Inhibition of human ERG in MCF7 cells [AID420668, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
36
[SID103168841]
IC50 0.0123Inhibition of human ERG in MCF7 cells [AID420668, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
37
[SID103168841]
IC50 0.015K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1 [AID82355, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
38
[SID103168841]
IC50 0.015K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1 [AID82355, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
39
[SID103168841]
IC50 0.015K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1 [AID82355, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
40
[SID103168841]
IC50 0.015K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1 [AID82355, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
41
[SID103168841]
IC50 0.015K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1 [AID82355, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
42
[SID103168841]
IC50 0.03Inhibitory concentration against IKr potassium channel [AID240820, Type: Literature]
View
43
[SID103168841]
IC50 0.04898Inhibition of human ERG channel in HEK293 cells by voltage-clamp method [AID392051, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
44
[SID103168841]
IC50 0.04898Inhibition of human ERG channel in HEK293 cells by voltage-clamp method [AID392051, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
45
[SID103168841]
IC50 0.04898Inhibition of human ERG channel in HEK293 cells by voltage-clamp method [AID392051, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
46
[SID103168841]
IC50 0.04898Inhibition of human ERG channel in HEK293 cells by voltage-clamp method [AID392051, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
47
[SID103168841]
IC50 0.04898Inhibition of human ERG channel in HEK293 cells by voltage-clamp method [AID392051, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
48
[SID103168841]
IC50 1In vitro inhibition of Rb efflux in human T-cells; 1-10 [AID89649, Type: other]
View
49
[SID103168841]
IC50 44Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytes [AID77985, Type: Literature]
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50
[SID103168841]
 Dose required to produce 20% increase in effective refractory period in male ferret. [AID71923, Type: Literature]
View