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CHEMBL2347383 (CID 71305072) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Unspecified(1)
 
 
Top Targets:
SWIB(4)
 
 
zf-RanBP(1)
 
 
BioAssay Types:
Literature(5)
 
 
 
BioActivity Types:
IC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 5    Data Row: 5   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID164132895]
IC50 0.086Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated for 20 mins followed by p53 addition measured after 60 mins by HTRF assay [AID739073, Type: Literature]E3 ubiquitin-protein ligase Mdm2 [gi:266516]
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2
[SID164132895]
IC50 2.9Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated for 20 mins followed by p53 addition measured after 60 mins by HTRF assay in presence of 15% serum [AID739072, Type: Literature]E3 ubiquitin-protein ligase Mdm2 [gi:266516]
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3
[SID164132895]
IC50 5.9Inhibition of MDM2-induced proliferation of human SJSA1 cells assessed as EdU incorporation by High content screening assay in presence of 10% serum [AID739071, Type: Literature]E3 ubiquitin-protein ligase Mdm2 [gi:266516]
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4
[SID164132895]
IC50 20.7Inhibition of MDM2 in human SJSA1 cells assessed as upregulation of p21 transcript level after 7 hrs by qRT-PCR analysis in presence of 10% serum [AID739070, Type: Literature]E3 ubiquitin-protein ligase Mdm2 [gi:266516]
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5
[SID164132895]
IC50 30Binding affinity to MDMX (unknown origin) after 20 mins by HTRF assay [AID739069, Type: Literature]Protein Mdm4 [gi:76803799]
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