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CHEMBL2347399 (CID 71305070) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1)
 
 
Unspecified(2)
 
 
Top Targets:
SWIB(2)
 
 
 
zf-RanBP(1)
 
 
BioAssay Types:
Literature(3)
 
 
 
BioActivity Types:
IC50(3)
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 3    Data Row: 3   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID164146875]
IC50 1Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated for 20 mins followed by p53 addition measured after 60 mins by HTRF assay [AID739073, Type: Literature]E3 ubiquitin-protein ligase Mdm2 [gi:266516]
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2
[SID164146875]
IC50 30Binding affinity to MDMX (unknown origin) after 20 mins by HTRF assay [AID739069, Type: Literature]Protein Mdm4 [gi:76803799]
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3
[SID164146875]
IC50 30Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated for 20 mins followed by p53 addition measured after 60 mins by HTRF assay in presence of 15% serum [AID739072, Type: Literature]E3 ubiquitin-protein ligase Mdm2 [gi:266516]
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