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CHEMBL2337850 (CID 71305068) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Inactive(3)
 
 
Unspecified(1)
 
 
Top Targets:
proteasome be..(3)
 
 
CysPc(1)
 
 
Peptidase C1A..(1)
 
 
proteasome be..(1)
 
 
proteasome be..(1)
 
 
BioAssay Types:
Literature(8)
 
 
 
 
BioActivity Types:
IC50(4)
 
 
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 8    Data Row: 8   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID164132676]
IC50 9.4Inhibition of chymotrypsin-like activity of yeast 20S proteasome beta-5 subunit using Suc-LLVY-AMC as substrate measured up to 45 mins by fluorescence assay [AID734272, Type: Literature]
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2
[SID164132676]
IC50 11.6Inhibition of chymotrypsin-like activity of human constitutive 20s proteasome beta-5 subunit using Suc-LLVY-AMC as substrate assessed as remaining activity incubated for 15 mins prior to substrate addition measured after 45 mins by fluorescence assay [AID734726, Type: Literature]Proteasome subunit beta type-5 [gi:187608890]
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3
[SID164132676]
Ki 24.5Noncompetitive inhibition of chymotrypsin-like activity of human constitutive 20s proteasome beta-5 subunit using Suc-LLVY-AMC as substrate assessed as inhibition constant for dissociation of enzyme-substrate-inhibitor complex incubated for 15 mins prior to substrate addition measured after 45 mins by fluorescence assay [AID734280, Type: Literature]Proteasome subunit beta type-5 [gi:187608890]
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4
[SID164132676]
Ki 24.5Noncompetitive inhibition of chymotrypsin-like activity of human constitutive 20s proteasome beta-5 subunit using Suc-LLVY-AMC as substrate assessed as inhibition constant for dissociation of enzyme-inhibitor complex incubated for 15 mins prior to substrate addition measured after 45 mins by fluorescence assay [AID734283, Type: Literature]Proteasome subunit beta type-5 [gi:187608890]
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5
[SID164132676]
IC50 51.2Inhibition of postacid activity of human constitutive 20s proteasome beta-1 subunit using Z-LLE-betaNA as substrate assessed as remaining activity incubated for 15 mins prior to substrate addition measured after 45 mins by fluorescence assay [AID734286, Type: Literature]Proteasome subunit beta type-1 [gi:130853]
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6
[SID164132676]
IC50 Inhibition of trypsin-like activity of human constitutive 20s proteasome beta-2 subunit using Boc-LRR-AMC as substrate assessed as remaining activity incubated for 15 mins prior to substrate addition measured after 45 mins by fluorescence assay [AID734285, Type: Literature]Proteasome subunit beta type-2 [gi:1709762]
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7
[SID164132676]
Inhibition of human cathepsin B using Suc-LLVY-AMC as substrate assessed as remaining enzyme activity at 20 uM incubated for 15 mins prior to substrate addition measured for 30 mins by fluorescence assay [AID734274, Type: Literature]Cathepsin B [gi:68067549]
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8
[SID164132676]
Inhibition of human calpain 1 using Suc-LLVY-AMC as substrate assessed as remaining enzyme activity at 20 uM incubated for 5 mins prior to substrate addition measured for 30 mins by fluorescence assay [AID734275, Type: Literature]Calpain-1 catalytic subunit [gi:115574]
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