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CHEMBL2347188 (CID 71305061) - Compound BioActivity Data
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BioActivity Outcomes:
Active(2)
 
 
Unspecified(9)
 
 
Top Targets:
beta secretas..(3)
 
 
 
CAP ED(1)
 
 
BioAssay Types:
Literature(11)
 
 
 
BioActivity Types:
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 11    Data Row: 11   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID164138552]
IC50 0.01Inhibition of human BACE1 in HEK293 cells transfected with wild type APP assessed as reduction of amyloid beta40 level after 18 to 20 hrs by AlphaLISA technique [AID738436, Type: Literature]Beta-secretase 1 [gi:296434407]
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2
[SID164138552]
IC50 0.013Inhibition of human BACE1 using MR121-labeled substrate incubated for 4 mins prior to substrate addition measured after 2 mins by spectrophotometric analysis [AID738154, Type: Literature]Beta-secretase 1 [gi:296434407]
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3
[SID164138552]
Reduction of amyloid beta40 level in C57B1/6J mouse brain at 1 mg/kg, po after 4 hrs by AlphaLISA relative to control [AID738424, Type: Literature]
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4
[SID164138552]
Reduction of amyloid beta40 level in C57B1/6J mouse brain at 3 mg/kg, po after 4 hrs by AlphaLISA relative to control [AID738425, Type: Literature]
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5
[SID164138552]
Inhibition of human ERG channel at 10 uM [AID738426, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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6
[SID164138552]
Efflux ratio, ratio of apparent permeability from basolateral to apical over apical to basolateral in pig LLC-PK1 cells expressing human MDR1 at 1 uM after 3.5 hrs by LC-MS/MS analysis [AID738427, Type: Literature]
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7
[SID164138552]
Lipophilicity, log P of the compound [AID738428, Type: Literature]
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8
[SID164138552]
Dissociation constant, pKa of the compound by capillary electrophoresis [AID738429, Type: Literature]
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9
[SID164138552]
Distribution coefficient, log D of the compound in 1-octanol/phosphate buffer at pH 7.4 after 24 hrs by shake flask method [AID738430, Type: Literature]
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10
[SID164138552]
Reduction of amyloid beta40 level in C57B1/6J mouse brain at 10 mg/kg, po after 4 hrs by AlphaLISA relative to control [AID738432, Type: Literature]
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11
[SID164138552]
Selectivity ratio of IC50 for human BACE1 to IC50 for BACE1 in HEK293 cells [AID738435, Type: Literature]Beta-secretase 1 [gi:296434407]
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