ZINC04164465 (CID 7117998) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(4)
 
 
Inactive(567)
 
 
Inconclusive(10)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
Bcl-2 like(10)
 
 
alkPPc(10)
 
 
7TM GPCR Srsx(8)
 
 
NR LBD PPAR(6)
 
 
BioAssay Types:
Screening(393)
 
 
 
Confirmatory(174)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(120)
 
 
 
 
 
IC50(35)
 
 
EC50(10)
 
 
 
AC50(3)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 582    Data Row: 582   Total Pages: 12   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103023200]
AC50 0.509Inhibition of Human GSK3 beta Activity Measured in Biochemical System Using Microfluidics - 2046-10_Inhibitor_Dose_DryPowder_Activity_Set2 [AID623989, Type: confirmatory]GSK3B gene product [Homo sapiens] [gi:21361340]
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2
[SID103023200]
AC50 0.509Inhibition of Human GSK3 beta Activity Measured in Biochemical System Using Microfluidics - 2046-10_Inhibitor_Dose_DryPowder_Activity_Set2 [AID623989, Type: confirmatory]GSK3B gene product [Homo sapiens] [gi:21361340]
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3
[SID103023200]
AC50 0.509Inhibition of Human GSK3 beta Activity Measured in Biochemical System Using Microfluidics - 2046-10_Inhibitor_Dose_DryPowder_Activity_Set2 [AID623989, Type: confirmatory]GSK3B gene product [Homo sapiens] [gi:21361340]
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4
[SID103023200]
AC50 1.87Inhibition of Human GSK3 alpha Activity Measured in Biochemical System Using Microfluidics - 2046-11_Inhibitor_Dose_DryPowder_Activity_Set2 [AID623978, Type: confirmatory]GSK3A gene product [Homo sapiens] [gi:49574532]
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5
[SID103023200]
AC50 1.87Inhibition of Human GSK3 alpha Activity Measured in Biochemical System Using Microfluidics - 2046-11_Inhibitor_Dose_DryPowder_Activity_Set2 [AID623978, Type: confirmatory]GSK3A gene product [Homo sapiens] [gi:49574532]
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6
[SID24815416]
EC50 4.592Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity [AID434954, Type: confirmatory]GSK3B gene product [Homo sapiens] [gi:21361340]
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7
[SID24815416]
EC50 4.592Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity [AID434954, Type: confirmatory]GSK3B gene product [Homo sapiens] [gi:21361340]
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8
[SID24815416]
EC50 4.592Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity [AID434954, Type: confirmatory]GSK3B gene product [Homo sapiens] [gi:21361340]
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9
[SID24815416]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID24815416]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID24815416]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID24815416]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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13
[SID24815416]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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14
[SID24815416]
Potency 14.581A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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15
[SID24815416]
Potency 35.4813qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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16
[SID24815416]
Potency 50.1187qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624288, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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17
[SID24815416]
EC50 300Luminescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of ADP-glo Reagents [AID434947, Type: confirmatory]
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18
[SID24815416]
IC90 Screen to Identify Novel Compounds That Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434955, Type: confirmatory]
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19
[SID24815416]
 uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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20
[SID24815416]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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21
[SID24815416]
 uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation [AID435022, Type: screening]
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22
[SID24815416]
 Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viability [AID449728, Type: screening]
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23
[SID24815416]
IC50 High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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24
[SID24815416]
 uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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25
[SID92102609]
 High Throughput Screen of a Putative Kinase Compound Library to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID2842, Type: confirmatory]
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26
[SID24815416]
 uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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27
[SID24815416]
 384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSC [AID463187, Type: screening]
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28
[SID24815416]
 Phenotypic HTS multiplex for antifungal efflux pump inhibitors [AID485275, Type: screening]
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29
[SID24815416]
Potency qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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30
[SID24815416]
 Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based assay to identify antagonists of the parental CHO cell line [AID463079, Type: screening]
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31
[SID24815416]
 HTS to identify inhibitors of TNF-alpha Induced Cell Death in Jurkat FADD-/- Cells. [AID463075, Type: screening]
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32
[SID24815416]
 Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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33
[SID24815416]
IC50 Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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34
[SID24815416]
IC50 Primary and Confirmatory Screening for Inhibitors of Bacterial Capsule Biogenesis [AID488966, Type: confirmatory]
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35
[SID24815416]
Potency qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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36
[SID24815416]
Potency qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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37
[SID24815416]
 HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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38
[SID24815416]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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39
[SID24815416]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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40
[SID24815416]
Potency qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. [AID1467, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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41
[SID24815416]
Potency qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. [AID1467, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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42
[SID24815416]
Potency qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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43
[SID24815416]
Potency qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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44
[SID24815416]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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45
[SID24815416]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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46
[SID24815416]
Potency qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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47
[SID24815416]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS16-Galphao. [AID1441, Type: screening]guanine nucleotide-binding protein G(o) subunit alpha isoform a [Homo sapiens] [gi:10567816]
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48
[SID24815416]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS16-Galphao. [AID1441, Type: screening]guanine nucleotide-binding protein G(o) subunit alpha isoform a [Homo sapiens] [gi:10567816]
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49
[SID24815416]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS16-Galphao. [AID1441, Type: screening]guanine nucleotide-binding protein G(o) subunit alpha isoform a [Homo sapiens] [gi:10567816]
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50
[SID24815416]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao. [AID1415, Type: screening]guanine nucleotide-binding protein G(o) subunit alpha isoform a [Homo sapiens] [gi:10567816]
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