benzidine (CID 7111) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(8)
 
 
Inactive(374)
 
 
Inconclusive(12)
 
 
Unspecified(17)
 
 
Top Targets:
7TM GPCR Srx(9)
 
 
7TM GPCR Srsx(5)
 
 
NR LBD PPAR(5)
 
 
BRLZ(4)
 
 
NR LBD TR(4)
 
 
 
BioAssay Types:
Confirmatory(204)
 
 
 
 
 
Screening(169)
 
 
Literature(20)
 
 
 
 
BioActivity Types:
Potency(161)
 
 
 
 
IC50(8)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 403    Data Row: 411   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179072]
IC50 1.42In vitro antitrypanosomal activity against Trypanosoma brucei rhodesiense [AID213470, Type: Literature]
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2
[SID87334335]
IC50 7.39Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens [AID624330, Type: confirmatory]RACGAP1 gene product [Homo sapiens] [gi:21361397]
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3
[SID87334335]
IC50 8Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Counter Screen Coupled Enzyme [AID624351, Type: confirmatory]
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4
[SID48413267]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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5
[SID48413267]
 DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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6
[SID48413267]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results [AID1199, Type: other]
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7
[SID48413267]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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8
[SID48413267]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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9
[SID103179072]
IC50 217Cytotoxic activity against rat L6 cells [AID99665, Type: Literature]
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10
[SID103179072]
 Carcinogenic activity on all sites after subcutaneous administration [AID167929, Type: Literature]
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11
[SID103179072]
 Carcinogenic activity on breast after subcutaneous administration [AID167943, Type: Literature]
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12
[SID103179072]
 Carcinogenic activity on ear duct after subcutaneous administration [AID167956, Type: Literature]
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13
[SID103179072]
 Carcinogenic activity on liver after subcutaneous administration [AID168090, Type: Literature]
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14
[SID103179072]
 Compound was tested for carcinogenic activity on mixed data after subcutaneous administration of the compound; + denotes carcinogenic activity. [AID168102, Type: Literature]
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15
[SID103179072]
 Carcinogenic activity on other sites after subcutaneous administration [AID168115, Type: Literature]
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16
[SID103179072]
 Specific activity of expressed human recombinant UGT1A3 [AID624607, Type: Literature]UDP-glucuronosyltransferase 1-4 [gi:136731]
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17
[SID103179072]
 Specific activity of expressed human recombinant UGT1A4 [AID624608, Type: Literature]UDP-glucuronosyltransferase 1-4 [gi:136731]
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18
[SID87334335]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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19
[SID87334335]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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20
[SID103179072]
 Aqueous solubility [AID19262, Type: Literature]
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21
[SID17390024]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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22
[SID103179072]
 Binding affinity against human UDP Glucuronosyltransferase 1A4 (UGT1A4) [AID214939, Type: Literature]
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23
[SID103179072]
 Ratio of cytotoxicity against L6 cells to that of antitrypanosomal activity against Trypanosoma brucei rhodesiense [AID231796, Type: Literature]
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24
[SID103179072]
 Partition coefficient, log P of the compound [AID310931, Type: Literature]
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25
[SID103179072]
 Permeability across PAMPA membrane after 7 hrs [AID310933, Type: Literature]
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26
[SID103179072]
 Binding affinity to beta cyclodextrin [AID346025, Type: Literature]
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27
[SID87334335]
Potency 19.9526qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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28
[SID87334335]
Potency 19.9526qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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29
[SID17390024]
Potency 25.1189qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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30
[SID17390024]
Potency 25.1189qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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31
[SID17390024]
Potency 25.1189qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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32
[SID17390024]
Potency 50.1187qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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33
[SID87334335]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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34
[SID87334335]
 PgID: DNTB colorimetric HTS to detect inhibitor of PgID Measured in Biochemical System Using Plate Reader - 2164-01_Inhibitor_SinglePoint_HTS_Activity [AID602405, Type: screening]WlaI protein (PglD) [gi:75495260]
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35
[SID17390024]
 qHTS Assay for Inhibitors of YjeE [AID605, Type: confirmatory]UPF0079 ATP-binding protein yjeE [gi:84028058]
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36
[SID17390024]
 Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) [AID584, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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37
[SID17390024]
 Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID585, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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38
[SID87334335]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID504803, Type: screening]HTRA1 protein [gi:121945198]
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39
[SID17390024]
Potency qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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40
[SID17390024]
Potency qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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41
[SID17390024]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore) [AID892, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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42
[SID17390024]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore) [AID875, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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43
[SID87334335]
 uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assay [AID602438, Type: screening]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 [gi:160877737]
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44
[SID87334335]
Potency qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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45
[SID87334335]
 High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set [AID588497, Type: Literature]botulinum neurotoxin type F, BoNT/F [Clostridium botulinum Bf] [gi:168184763]
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46
[SID87334335]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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47
[SID87334335]
IC50 Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition [AID588689, Type: confirmatory]Chain A, Crystal Structure Of Dengue-2 Virus Methyltransferase Complexed With S-Adenosyl-L-Homocyste [gi:219689243]
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48
[SID87334335]
IC50 Discovery of Small Molecule Probes for H1N1 Influenza NS1A [AID504329, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/California/07/2009(H1N1))] [gi:227977143]
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49
[SID17390024]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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50
[SID17390024]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent) [AID1478, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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