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benzidine (CID 7111) - Compound BioActivity Data
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BioActivity Outcomes:
Active(22)
 
 
Inactive(577)
 
 
Inconclusive(45)
 
 
Unspecified(17)
 
 
Top Targets:
NR LBD PPAR(21)
 
 
 
NR LBD ER(16)
 
 
 
NR LBD AR(16)
 
 
 
7TM GPCR Srx(12)
 
 
7TM GPCR Srsx(11)
 
 
BioAssay Types:
Confirmatory(354)
 
 
 
 
 
Screening(220)
 
 
 
Summary(48)
 
 
 
 
Literature(20)
 
 
 
 
BioActivity Types:
Potency(346)
 
 
 
 
 
IC50(8)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 533    Data Row: 661   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179072]
IC50 1.42In vitro antitrypanosomal activity against Trypanosoma brucei rhodesiense [AID213470, Type: Literature]
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2
[SID87334335]
IC50 7.39Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens [AID624330, Type: confirmatory]rac GTPase-activating protein 1 [Homo sapiens] [gi:21361397]
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3
[SID87334335]
IC50 8Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Counter Screen Coupled Enzyme [AID624351, Type: confirmatory]
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4
[SID144209557]
Potency-Replicate_1 9.5803qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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5
[SID144210723]
AhR Potency (uM) 10.4614qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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6
[SID144209557]
AhR Potency (uM) 16.395qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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7
[SID144210723]
Ratio Potency (uM) 24.3365qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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8
[SID144209557]
Potency-Replicate_1 48.0151qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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9
[SID144210723]
Potency-Replicate_1 48.5577qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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10
[SID144209557]
ATAD5 Potency (uM) 60.4474qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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11
[SID144209557]
Potency-Replicate_1 60.4474qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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12
[SID144210723]
Potency-Replicate_1 61.1306qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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13
[SID144210723]
Potency-Replicate_1 61.1306qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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14
[SID144210723]
Potency-Replicate_1 61.1306qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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15
[SID144209557]
Ratio Potency (uM) 67.8231qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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16
[SID144209557]
Potency-Replicate_1 67.8231qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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17
[SID48413267]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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18
[SID48413267]
DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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19
[SID48413267]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results [AID1199, Type: other]
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20
[SID48413267]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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21
[SID48413267]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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22
[SID87334335]
QFRET-based biochemical high throughput primary assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2) [AID743126, Type: screening]phospholipase A2, group III [Homo sapiens] [gi:119580345]
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23
[SID103179072]
IC50 217Cytotoxic activity against rat L6 cells [AID99665, Type: Literature]
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24
[SID103179072]
Km 460Binding affinity against human UDP Glucuronosyltransferase 1A4 (UGT1A4) [AID214939, Type: Literature]
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25
[SID103179072]
Ratio of cytotoxicity against L6 cells to that of antitrypanosomal activity against Trypanosoma brucei rhodesiense [AID231796, Type: Literature]
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26
[SID103179072]
Partition coefficient, log P of the compound [AID310931, Type: Literature]
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27
[SID103179072]
Permeability across PAMPA membrane after 7 hrs [AID310933, Type: Literature]
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28
[SID103179072]
Binding affinity to beta cyclodextrin [AID346025, Type: Literature]
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29
[SID103179072]
Carcinogenic activity on all sites after subcutaneous administration [AID167929, Type: Literature]
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30
[SID103179072]
Carcinogenic activity on breast after subcutaneous administration [AID167943, Type: Literature]
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31
[SID103179072]
Carcinogenic activity on ear duct after subcutaneous administration [AID167956, Type: Literature]
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32
[SID103179072]
Carcinogenic activity on liver after subcutaneous administration [AID168090, Type: Literature]
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33
[SID103179072]
Compound was tested for carcinogenic activity on mixed data after subcutaneous administration of the compound; + denotes carcinogenic activity. [AID168102, Type: Literature]
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34
[SID103179072]
Carcinogenic activity on other sites after subcutaneous administration [AID168115, Type: Literature]
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35
[SID103179072]
Aqueous solubility [AID19262, Type: Literature]
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36
[SID103179072]
Specific activity of expressed human recombinant UGT1A3 [AID624607, Type: Literature]UDP-glucuronosyltransferase 1-4 [gi:136731]
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37
[SID103179072]
Specific activity of expressed human recombinant UGT1A4 [AID624608, Type: Literature]UDP-glucuronosyltransferase 1-4 [gi:136731]
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38
[SID87334335]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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39
[SID17390024]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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40
[SID144209557]
Potency-Replicate_1 3.814qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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41
[SID144210723]
Potency-Replicate_1 4.8558qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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42
[SID144209557]
Potency-Replicate_1 9.5803qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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43
[SID144210723]
Potency-Replicate_1 9.6885qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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44
[SID87334335]
Potency 19.9526qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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45
[SID87334335]
Potency 19.9526qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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46
[SID17390024]
Potency 25.1189qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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47
[SID144209557]
Potency-Replicate_1 38.4579qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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48
[SID17390024]
Potency 50.1187qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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49
[SID87334335]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human trace amine associated receptor 1 (TAAR1) [AID624466, Type: screening]trace amine-associated receptor 1 [Homo sapiens] [gi:21264324]
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50
[SID87334335]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID624467, Type: screening]trace amine-associated receptor 1 [Homo sapiens] [gi:21264324]
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