Proflavine (CID 7099) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(39)
 
 
Inactive(20)
 
 
Inconclusive(60)
 
 
Unspecified(43)
 
 
Top Targets:
DUF3652(2)
 
 
 
Geminin(2)
 
 
TetR C 5(2)
 
 
Telomerase RB..(2)
 
 
Menin(2)
 
 
 
BioAssay Types:
Literature(124)
 
 
 
 
 
Confirmatory(35)
 
 
 
 
BioActivity Types:
Potency(33)
 
 
 
 
IC50(14)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 99    Data Row: 162   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103244999]
IC50 0.12Antiamastigote activity against Leishmania infantum [AID295906, Type: Literature]
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2
[SID103244999]
IC50 0.47Concentration required to inhibit the cell growth by 50 % after 96 hr A2780 leukemic cells. [AID10004, Type: Literature]
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3
[SID103244999]
IC50 0.47Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs [AID10007, Type: Literature]
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4
[SID103244999]
IC50 0.47Compound was evaluated for cytotoxicity against A2780 cell lines. [AID7465, Type: other]
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5
[SID103244999]
IC50 0.52Phototoxicity in transformed CHO cells after 24 hrs of UV irradiation by WST1 assay [AID420946, Type: Literature]
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6
[SID103244999]
IC50 1.1Phototoxicity in transformed CHO cells after 24 hrs incubation in dark by WST1 assay [AID420945, Type: Literature]
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7
[SID29218003]
Potency 1.1264qHTS Fluorescence Polarization (FP) Assay for Inhibitors of MLL CXXC domain - DNA interaction: Fluorescein FP [AID624160, Type: confirmatory]
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8
[SID103244999]
IC50 1.3Antipromastigote activity against Leishmania infantum [AID295904, Type: Literature]
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9
[SID103244999]
IC50 2.21Cytotoxicity against human THP1 cells [AID295905, Type: Literature]
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10
[SID29218003]
Potency 2.3934Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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11
[SID103244999]
IC50 2.7Concentration required to inhibit the cell growth by 50 % after 48 hr in L1210 leukemic cells. [AID98558, Type: Literature]
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12
[SID103244999]
IC50 2.7Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs [AID98563, Type: Literature]
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13
[SID29218003]
Potency 3.7933Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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14
[SID29218003]
Potency 9.4662qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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15
[SID29218003]
Potency 9.4662qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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16
[SID29218003]
Potency 12.5893qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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17
[SID29218003]
Potency 12.5893qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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18
[SID29218003]
Potency 28.1838qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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19
[SID29218003]
Potency 35.6203qHTS Fluorescence Polarization (FP) Assay for Inhibitors of MLL CXXC domain - DNA interaction: Texas Red FP [AID624161, Type: confirmatory]
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20
[SID46391536]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain H, Alpha-Thrombin Complexed With Hirugen And Proflavin [gi:3891955]
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21
[SID46393030]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain B, Crystal Structure Of The Multidrug Binding Transcriptional Repressor Qacr Bound To The Drug [gi:51247257]
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22
[SID46393031]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain B, Crystal Structure Of The Multidrug Binding Transcriptional Repressor Qacr Bound To Two Drug [gi:51247261]
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23
[SID29218003]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_19, Type: Literature]
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24
[SID29218003]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_23, Type: Literature]
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25
[SID29218003]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_24, Type: Literature]
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26
[SID29218003]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_49, Type: Literature]
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27
[SID29218003]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_17, Type: Literature]
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28
[SID29218003]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_53, Type: Literature]
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29
[SID29218003]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_57, Type: Literature]
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30
[SID29218003]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_58, Type: Literature]
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31
[SID29218003]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_55, Type: Literature]
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32
[SID29218003]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_27, Type: Literature]
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33
[SID103244999]
 Inhibitory concentration against ethidium in DNA-binding assay with [poly(dA-dT)]2 (synthetic oligonucleotide) [AID225777, Type: Literature]
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34
[SID103244999]
 Inhibitory concentration against ethidium in DNA-binding assay with [poly(dG-dC)]2 (synthetic oligonucleotide) [AID225778, Type: Literature]
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35
[SID103244999]
 Inhibitory concentration against ethidium:Calf thymus DNA(0.1:1) binding at pH 5 [AID46169, Type: Literature]
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36
[SID103244999]
 Inhibitory concentration against ethidium in DNA-binding assay [AID54658, Type: Literature]
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37
[SID103244999]
 Concentration required to give 50% fluorescence quenching of bound ethidium for [ethidium] : [(poly dG-dC)]2 DNA in ratio of 0.1:1 at pH 5 [AID55499, Type: Literature]
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38
[SID103244999]
 Concentration required to give 50% fluorescence quenching of bound ethidium for [ethidium] : [poly(dA-dT)]2 DNA in ratio of 0.1:1 at pH 5 [AID55500, Type: Literature]
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39
[SID103244999]
 Clastogenic activity in CHOK1 cells assessed as lowest drug concentration required to increase number of micronucleated cells after 3 hrs incubation in dark by micronucleus assay [AID420951, Type: Literature]
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40
[SID103244999]
 Clastogenic activity in CHOK1 cells assessed as lowest drug concentration required to increase number of micronucleated cells after 3 hrs of UV irradiation by micronucleus assay [AID420952, Type: Literature]
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41
[SID29218003]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_3, Type: Literature]
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42
[SID103244999]
IC50 1Cytotoxic effect in human peripheral blood monocyte cells(PBMC) [AID152935, Type: Literature]
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43
[SID103244999]
IC50 50Phototoxicity in normal human keratinocytes after 24 hrs incubation in dark by WST1 assay [AID420948, Type: Literature]
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44
[SID103244999]
IC50 50Phototoxicity in normal human keratinocytes after 24 hrs of UV irradiation by WST1 assay [AID420949, Type: Literature]
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45
[SID103244999]
IC50 250Binding affinity to DNA by DNA-methyl green bioassay [AID295908, Type: Literature]
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46
[SID29218003]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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47
[SID103244999]
 Minimal bacteriostatic concentration against streptococcus pyogenes under conditions of pH 7.3, 37 degree C; 1 in 160000 [AID209937, Type: Literature]
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48
[SID103244999]
 Compound is evaluated for trypanocidal activity against Trypanosoma brucei, by exposing the parasites directly to compound prior to injection to mice at 10 E-4 M concentration in dark conditions [AID214983, Type: Literature]
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49
[SID103244999]
 Compound is evaluated for trypanocidal activity against Trypanosoma brucei, by exposing the parasites directly to compound prior to injection to mice at 10 E-4 M concentration in presence of light [AID214984, Type: Literature]
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50
[SID103244999]
 Compound is evaluated for trypanocidal activity against Trypanosoma brucei, by exposing the parasites directly to compound prior to injection to mice at 10 E-5 M concentration in dark conditions [AID214987, Type: Literature]
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