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Proflavine (CID 7099) - Compound BioActivity Data
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BioActivity Outcomes:
Active(47)
 
 
Inactive(22)
 
 
Inconclusive(61)
 
 
Unspecified(43)
 
 
Top Targets:
Bromo ALL-1(3)
 
 
 
Tryp SPc(3)
 
 
Telomerase RB..(2)
 
 
Geminin(2)
 
 
NR LBD TR(2)
 
 
BioAssay Types:
Literature(132)
 
 
 
 
 
Confirmatory(39)
 
 
 
 
BioActivity Types:
Potency(35)
 
 
 
 
IC50(14)
 
 
 
Kd(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 100    Data Row: 173   Total Pages: 9   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID170481301]
Kd 0.079Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of The Tetr-Like Transcriptional Regulator Lfrr From Mycobacterium Smegmatis In Complex With Proflavine [gi:261824474]
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2
[SID170481301]
Kd 0.079Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of The Tetr-Like Transcriptional Regulator Lfrr From Mycobacterium Smegmatis In Complex With Proflavine [gi:261824474]
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3
[SID103244999]
IC50 0.12Antiamastigote activity against Leishmania infantum [AID295906, Type: Literature]
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4
[SID103244999]
IC50 0.47Compound was evaluated for cytotoxicity against A2780 cell lines. [AID7465, Type: confirmatory]
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5
[SID103244999]
IC50 0.47Concentration required to inhibit the cell growth by 50 % after 96 hr A2780 leukemic cells. [AID10004, Type: Literature]
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6
[SID103244999]
IC50 0.47Cytotoxic potency required to inhibit A2780 cell growth by 50% after cell drug contact for 96 hrs [AID10007, Type: Literature]
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7
[SID103244999]
IC50 0.52Phototoxicity in transformed CHO cells after 24 hrs of UV irradiation by WST1 assay [AID420946, Type: Literature]
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8
[SID103244999]
IC50 1.1Phototoxicity in transformed CHO cells after 24 hrs incubation in dark by WST1 assay [AID420945, Type: Literature]
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9
[SID29218003]
Potency 1.1264qHTS Fluorescence Polarization (FP) Assay for Inhibitors of MLL CXXC domain - DNA interaction: Fluorescein FP [AID624160, Type: confirmatory]
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10
[SID103244999]
IC50 1.3Antipromastigote activity against Leishmania infantum [AID295904, Type: Literature]
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11
[SID103244999]
IC50 2.21Cytotoxicity against human THP1 cells [AID295905, Type: Literature]
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12
[SID29218003]
Potency 2.3934Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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13
[SID103244999]
IC50 2.7Concentration required to inhibit the cell growth by 50 % after 48 hr in L1210 leukemic cells. [AID98558, Type: Literature]
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14
[SID103244999]
IC50 2.7Cytotoxic potency required to inhibit L1210 cell growth by 50% after cell drug contact for 48 hrs [AID98563, Type: Literature]
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15
[SID29218003]
Potency 3.7933Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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16
[SID29218003]
Potency 9.4662qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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17
[SID29218003]
Potency 12.5893qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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18
[SID29218003]
Potency 28.1838qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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19
[SID46393031]
Kd 35Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of The Multidrug Binding Transcriptional Repressor Qacr Bound To Two Drugs: Ethidium And Proflavine [gi:51247263]
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20
[SID46393031]
Kd 35Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of The Multidrug Binding Transcriptional Repressor Qacr Bound To Two Drugs: Ethidium And Proflavine [gi:51247263]
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