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dehydrothio-4-toluidine (CID 7087) - Compound BioActivity Data
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BioActivity Outcomes:
Active(64)
 
 
Inactive(551)
 
 
Inconclusive(27)
 
 
Unspecified(11)
 
 
Top Targets:
7TM GPCR Srx(18)
 
 
7TM GPCR Srsx(17)
 
 
Death TRAILR..(12)
 
 
 
 
Firefly Luc l..(10)
 
 
Peptidase C48(8)
 
 
 
BioAssay Types:
Screening(419)
 
 
 
 
 
Confirmatory(206)
 
 
 
 
 
Literature(14)
 
 
 
 
 
BioActivity Types:
Potency(149)
 
 
 
 
 
IC50(35)
 
 
 
EC50(10)
 
 
AC50(5)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 593    Data Row: 653   Total Pages: 33   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103304043]
Ki 0.0095Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1. [AID38663, Type: Literature]
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2
[SID26667283]
Potency 0.0231FLuc inhibitory activity for the follow-up compounds in a biochemical assay with 1mM ATP [AID602364, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID26667283]
Potency 0.0326FLuc inhibitory activity for the follow-up compounds in a biochemical assay with Km concentrations of substrate and 500microM CoASH [AID602358, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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4
[SID26667283]
Potency 0.0356FLuc inhibitory activity for the follow-up compounds in a cell-based assay to assess the activity of miR-21 [AID602477, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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5
[SID26667283]
Potency 0.04FLuc inhibitory activity for the follow-up compounds in a cell-based translational read-through assay [AID602476, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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6
[SID26667283]
Potency 0.0819FLuc inhibitory activity for the follow-up compounds in a biochemical assay with Km concentrations of substrate [AID602357, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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7
[SID26667283]
Potency 0.1069qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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8
[SID26667283]
Potency 0.2239qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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9
[SID26667283]
Potency 0.3162qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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10
[SID26667283]
Potency 0.5168FLuc inhibitory activity for the follow-up compounds in a biochemical assay with 1mM D-luciferin [AID602365, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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11
[SID26667283]
Potency 0.8954FLuc inhibitory activity for the follow-up compounds in a biochemical assay with a commercial detection reagent - BriteliteTM Plus (PerkinElmer) [AID602474, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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12
[SID26667283]
Potency 1.4192FLuc inhibitory activity for the follow-up compounds in a cell-based translational read-through assay (72 hour incubation) [AID602478, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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13
[SID26667283]
AC50_uM 1.55LGR2:Counterscreen with MC4R Measured in Cell-Based System Using Plate Reader - 7011-02_Antagonist_Dose_CherryPick_Activity [AID743444, Type: confirmatory]MSH [Drosophila melanogaster] [gi:1098680]
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14
[SID26667283]
AC50_uM 1.88Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition Measured in Cell-Based System Using Plate Reader - 7011-01_Antagonist_Dose_CherryPick_Activity_Set2 [AID743343, Type: confirmatory]
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15
[SID29217087]
Potency 3.5481qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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16
[SID26667283]
Potency 3.5481qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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17
[SID26667283]
Potency 4.4668qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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18
[SID26667283]
Potency 4.4668qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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19
[SID26667283]
Potency 4.9135FLuc inhibitory activity for the follow-up compounds in a biochemical assay with an in-house formulation of detection reagent [AID602475, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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20
[SID26667283]
Potency 5.6234qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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