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CHEMBL2089182 (CID 70689178) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(4)
 
 
Unspecified(5)
 
 
Top Targets:
PBP1 mGluR gr..(3)
 
 
 
BioAssay Types:
Literature(15)
 
 
 
 
BioActivity Types:
Ki(1)
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 15    Data Row: 15   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID160686576]
Ki 0.0027Displacement of [3H]MPEP from mGluR5 in Sprague-Dawley rat brain membrane after 60 mins by liquid scintillation counting [AID683163, Type: Literature]Metabotropic glutamate receptor 5 [gi:1170947]
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2
[SID160686576]
IC50 0.009Inverse agonist activity at rat mGluR5 expressed in HEK293A cells coexpressing Gqalpha assessed as inhibition of quisqualic-induced D-myo-inositol 1 production by ELISA [AID683165, Type: Literature]Metabotropic glutamate receptor 5 [gi:1170947]
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3
[SID160686576]
Anxiolytic activity in Swiss Webster mouse assessed as increase in locomotor activity at 0.1 to 0.3 mg/kg, ip administered as single dose 15 mins prior to testing by open-field test [AID683182, Type: Literature]
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4
[SID160686576]
Anxiolytic activity in Swiss Webster mouse assessed as increase in time spent in the centre region at 0.1 to 0.3 mg/kg, ip administered as single dose 15 mins prior to testing by open-field test [AID683183, Type: Literature]
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5
[SID160686576]
Anxiolytic activity in Swiss Webster mouse assessed as increase in time spent in light compartment at 0.1 to 0.3 mg/kg, ip administered as single dose 15 mins prior to testing by light-dark box test [AID683184, Type: Literature]
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6
[SID160686576]
Anxiolytic activity in Swiss Webster mouse assessed as increase in number of compartment transitions at 0.1 to 0.3 mg/kg, ip administered as single dose 15 mins prior to testing by light-dark box test [AID683185, Type: Literature]
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7
[SID160686576]
Ratio of MPEP Ki to compound Ki for mGluR5 in Sprague-Dawley rat brain membrane [AID683164, Type: Literature]Metabotropic glutamate receptor 5 [gi:1170947]
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8
[SID160686576]
Anxiolytic activity in ip dosed Swiss Webster mouse assessed as increase in locomotor activity administered as single dose 15 mins prior to testing by open-field test [AID683166, Type: Literature]
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9
[SID160686576]
Anxiolytic activity in ip dosed Swiss Webster mouse assessed as increase in time spent in the centre region administered as single dose 15 mins prior to testing by open-field test [AID683167, Type: Literature]
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10
[SID160686576]
Anxiolytic activity in ip dosed Swiss Webster mouse assessed as increase in time spent in light compartment administered as single dose 15 mins prior to testing by light-dark box test [AID683168, Type: Literature]
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11
[SID160686576]
Anxiolytic activity in ip dosed Swiss Webster mouse assessed as increase in number of compartment transitions administered as single dose 15 mins prior to testing by light-dark box test [AID683169, Type: Literature]
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12
[SID160686576]
Anxiolytic activity in Swiss Webster mouse assessed as increase in locomotor activity at 3 mg/kg, ip administered as single dose 15 mins prior to testing by open-field test [AID683186, Type: Literature]
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13
[SID160686576]
Anxiolytic activity in Swiss Webster mouse assessed as increase in time spent in the centre region at 3 mg/kg, ip administered as single dose 15 mins prior to testing by open-field test [AID683187, Type: Literature]
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14
[SID160686576]
Anxiolytic activity in Swiss Webster mouse assessed as increase in time spent in light compartment at 3 mg/kg, ip administered as single dose 15 mins prior to testing by light-dark box test [AID683188, Type: Literature]
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15
[SID160686576]
Anxiolytic activity in Swiss Webster mouse assessed as increase in number of compartment transitions at 3 mg/kg, ip administered as single dose 15 mins prior to testing by light-dark box test [AID683189, Type: Literature]
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