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BioActivity Data for Compound Aminacrine (CID 7019)

BioActivity Outcomes:
Active(26)
 
 
Inactive(70)
 
 
Inconclusive(23)
 
 
Unspecified(42)
 
 
Top Targets:
PLDc mTdp1 2(3)
 
 
 
P53(2)
 
 
NR LBD TR(2)
 
 
NR LBD ROR li..(2)
 
 
 
Menin(2)
 
 
BioAssay Types:
Confirmatory(71)
 
 
 
 
 
Literature(62)
 
 
 
 
 
Screening(12)
 
 
 
BioAssay Categories:
In vitro(3)
 
 
 
In vivo(2)
 
 
Biochemical(30)
 
 
 
Toxicity(6)
 
 
 
 
ADME(6)
 
 
 
Cell-based(20)
 
 
 
 
 
BioActivity Types:
Potency(68)
 
 
 
 
IC50(4)
 
 
 
 
Ki(3)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 151    Data Row: 161   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID208013951]
Ki 0.025Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]
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2
[SID208013951]
Ki 0.025Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]
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3
[SID103217574]
ID50 1.9In vitro inhibitory dose that reduces L1210 cell line by 50% when added for a period of 70h [AID96818, Type: Literature]
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4
[SID103217574]
GI50 2Growth inhibition of human HL60 cells [AID539397, Type: Literature]
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5
[SID103217574]
IC50 2.14Cytotoxic effect in human peripheral blood monocyte cells(PBMC) [AID152935, Type: Literature]
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6
[SID103217574]
IC50 2.6Evaluated for concentration which when added to cultures of L1210 leukemia cells for a period of 70 hr reduces cell numbers of 50% of control cultures [AID98315, Type: Literature]
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7
[SID26748404]
Potency 3.2643qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID26748404]
Potency 3.6626qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID103217574]
EC50 9.19Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay [AID1129462, Type: Literature]
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10
[SID26748404]
Potency 15.8489qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1: Spectroscopic Profiling in AFC Spectral Region [AID923, Type: confirmatory]
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11
[SID26748404]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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12
[SID26748404]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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13
[SID26748404]
Potency 31.6228qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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14
[SID103217574]
Ki 38The competitive inhibitory activity against trypanothione reductase was evaluated from Lineweaver Burk plots [AID214657, Type: Literature]Trypanothione reductase [gi:136620]
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15
[SID26748404]
Potency qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [Marburg marburgvirus] [gi:420597]
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16
[SID85789566]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of STK33 [AID2330, Type: screening]serine/threonine kinase 33 [Homo sapiens] [gi:12830367]
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17
[SID77577]
NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain [AID175, Type: other]
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18
[SID77577]
NCI Yeast Anticancer Drug Screen. Data for the bub3 strain [AID167, Type: other]
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19
[SID77577]
NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain [AID165, Type: other]
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20
[SID77577]
NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain [AID161, Type: other]
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