Aminacrine (CID 7019) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(21)
 
 
Inactive(63)
 
 
Inconclusive(20)
 
 
Unspecified(34)
 
 
Top Targets:
HELICc(2)
 
 
Peptidase C1A(2)
 
 
PLN02808(2)
 
 
Menin(2)
 
 
STKc ERK1 2 l..(2)
 
 
BioAssay Types:
Confirmatory(63)
 
 
 
 
 
Literature(48)
 
 
 
 
 
Screening(12)
 
 
 
BioActivity Types:
Potency(61)
 
 
 
 
IC50(4)
 
 
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 134    Data Row: 138   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103217574]
ID50 1.9In vitro inhibitory dose that reduces L1210 cell line by 50% when added for a period of 70h [AID96818, Type: Literature]
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2
[SID103217574]
GI50 2Growth inhibition of human HL60 cells [AID539397, Type: Literature]
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3
[SID103217574]
IC50 2.14Cytotoxic effect in human peripheral blood monocyte cells(PBMC) [AID152935, Type: Literature]
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4
[SID103217574]
IC50 2.6Evaluated for concentration which when added to cultures of L1210 leukemia cells for a period of 70 hr reduces cell numbers of 50% of control cultures [AID98315, Type: Literature]
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5
[SID26748404]
Potency 3.2643qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID26748404]
Potency 3.2643qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID26748404]
Potency 3.2643qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID26748404]
Potency 3.6626qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID26748404]
Potency 3.6626qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID26748404]
Potency 3.6626qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID26748404]
Potency 15.8489qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1: Spectroscopic Profiling in AFC Spectral Region [AID923, Type: confirmatory]
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12
[SID26748404]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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13
[SID26748404]
Potency 31.6228qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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14
[SID26748404]
Potency 31.6228qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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15
[SID103217574]
Ki 38The competitive inhibitory activity against trypanothione reductase was evaluated from Lineweaver Burk plots [AID214657, Type: Literature]Trypanothione reductase [gi:136620]
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16
[SID103217574]
 Cytotoxicity against mouse ScN2a cells assessed as maximal tolerant concentration [AID344297, Type: Literature]
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17
[SID103217574]
 Binding affinity to amyloid beta (1 to 42) fibrils by change in fluorescence at 100 uM after 10 mins [AID475504, Type: Literature]
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18
[SID103217574]
 Binding affinity to amyloid beta (1 to 42) oligomers by change in fluorescence at 100 uM after 10 mins [AID475505, Type: Literature]
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19
[SID77577]
 NCI Yeast Anticancer Drug Screen. Data for the rad50 strain [AID155, Type: other]
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20
[SID77577]
 NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain [AID157, Type: other]
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21
[SID77577]
 NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain [AID161, Type: other]
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22
[SID77577]
 NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain [AID165, Type: other]
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23
[SID77577]
 NCI Yeast Anticancer Drug Screen. Data for the bub3 strain [AID167, Type: other]
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24
[SID77577]
 NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain [AID175, Type: other]
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25
[SID103217574]
 Inhibitory concentration against ethidium bromide binding to DNA [AID54256, Type: Literature]
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26
[SID85789566]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of STK33 [AID2330, Type: screening]serine/threonine kinase 33 [Homo sapiens] [gi:12830367]
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27
[SID85789566]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of STK33 [AID2330, Type: screening]serine/threonine kinase 33 [Homo sapiens] [gi:12830367]
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28
[SID85789566]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of STK33 [AID2330, Type: screening]serine/threonine kinase 33 [Homo sapiens] [gi:12830367]
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29
[SID103217574]
IC50 120Inhibition of apamin-sensitive SKCa channel of guinea-pig hepatocytes [AID241212, Type: Literature]
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30
[SID103217574]
 Displacement of ethidium bromide from calf thymus DNA by fluorometric assay [AID539396, Type: Literature]
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31
[SID103217574]
 Binding affinity to calf thymus DNA assessed as reduction in DNA peak by pre-incubation method [AID357845, Type: other]
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32
[SID103217574]
 Binding affinity to yeast tRNA assessed as reduction in tRNA peak by pre-incubation method [AID357846, Type: other]
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33
[SID103217574]
 Compound administered intraperitoneally was evaluated for optimal dose (OD) given per day after inoculation of 10e 6 P388 leukemia cells for highest nontoxic dose [AID152666, Type: Literature]
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34
[SID103217574]
 Highest nontoxic optimal dose administered intraperitoneally after inoculation of P388 leukemia cells [AID152669, Type: Literature]
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35
[SID103217574]
 Percentage increase in life span treated animals over those of controls injected with P388 leukemia cells [AID153868, Type: Literature]
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36
[SID103217574]
 The % increase in lifespan of treated animals over that of control group of animals injected with tumor alone [AID153997, Type: Literature]
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37
[SID103217574]
 Minimal bacteriostatic concentration against streptococcus pyogenes under conditions of pH 7.3, 37 degree C; 1 in 160000 [AID209937, Type: Literature]
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38
[SID103217574]
 Association constant for binding to poly(dA-dT) DNA in 0.01 SHE buffer, measured by ethidium displacement method for equilibrium binding to calf thymus DNA [AID225780, Type: Literature]
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39
[SID103217574]
 Association constant for binding to poly(dG-dC) DNA in 0.01 SHE buffer, measured by ethidium displacement method for equilibrium binding to calf thymus DNA [AID225923, Type: Literature]
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40
[SID103217574]
 Fraction of the observed equilibrium absorbance change accounted in the kinetic analysis [AID227384, Type: Literature]
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41
[SID103217574]
 Fraction of the observed equilibrium absorbance change accounted in the kinetic analysis; too fast to measure [AID227507, Type: Literature]
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42
[SID103217574]
 Difference between log K of (AT) and log K of (GC) DNA binding [AID228718, Type: Literature]
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43
[SID103217574]
 Time constant describing the association profile of calf thymus DNA-drug complexes in 0.1 SHE buffer at 20 degree C after 1 min; too fast to measure [AID234984, Type: Literature]
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44
[SID103217574]
 Time constant describing the dissociation profile of calf thymus DNA-drug complexes in 0.1 SHE buffer at 20 degree C [AID234985, Type: Literature]
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45
[SID103217574]
 Time constant describing the association profile of calf thymus DNA-drug complexes in 0.1 SHE buffer at 20 degree C after 2 min; too fast to measure [AID234989, Type: Literature]
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46
[SID103217574]
 Time constant describing the dissociation profile of calf thymus DNA-drug complexes in 0.1 SHE buffer at 20 degree C [AID234990, Type: Literature]
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47
[SID103217574]
 Time constant describing the association profile of calf thymus DNA-drug complexes in 0.1 SHE buffer at 20 degree C after 3 min; too fast to measure [AID234991, Type: Literature]
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48
[SID103217574]
 DNA-bound drug concentration in 0.1 SHE buffer at the concentration of 50 uM for equilibrium binding to calf thymus DNA [AID54263, Type: Literature]
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49
[SID103217574]
 Free drug concentration in 0.1 SHE buffer at the concentration of 50 uM for equilibrium binding to calf thymus DNA [AID54264, Type: Literature]
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50
[SID103217574]
 Free drug concentration in 0.1 SHE buffer at the concentration of 50 uM; 9.4 x 10 e-3 epcilonfor equilibrium binding to calf thymus DNA [AID54265, Type: Literature]
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