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diphenylthiourea (CID 700999) - Compound BioActivity Data
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BioActivity Outcomes:
Active(10)
 
 
Inactive(211)
 
 
Inconclusive(38)
 
 
Unspecified(7)
 
 
Top Targets:
NR LBD PPAR(13)
 
 
 
NR LBD ER(9)
 
 
 
NR LBD AR(9)
 
 
 
NR LBD TR(7)
 
 
 
NR LBD VDR(6)
 
 
 
BioAssay Types:
Confirmatory(212)
 
 
 
 
Summary(24)
 
 
 
 
Literature(9)
 
 
 
 
BioActivity Types:
Potency(194)
 
 
 
 
IC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 253    Data Row: 266   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103168639]
IC50 4.5Inhibition of alpha-MSH -stimulated melanogenesis in mouse B16 cells assessed as melanin release after 72 hrs by spectrometric analysis [AID626572, Type: Literature]
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2
[SID144207467]
Potency-Replicate_1 17.5096qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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3
[SID17388694]
Potency 19.9526qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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4
[SID17388694]
Potency 19.9526qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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5
[SID144207467]
Ratio Potency (uM) 31.4104qHTS assay for small molecule activators of the heat shock response signaling pathway: Summary [AID743228, Type: summary]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
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6
[SID17388694]
Potency 31.6228qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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7
[SID144207467]
Potency-Replicate_1 34.9363qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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8
[SID144207467]
ER Potency (uM) 49.3489qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line: Summary [AID743091, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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9
[SID144207467]
Potency-Replicate_1 49.3489qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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10
[SID144207467]
Potency-Replicate_1 49.3489qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743080, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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11
[SID103168639]
IC50 100Inhibition of mushroom tyrosinase activity using L-tyrosine as substrate by spectrometric analysis [AID626570, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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12
[SID103168639]
Inhibition of mushroom tyrosinase activity using L-tyrosine as substrate at 10 uM by spectrometric analysis [AID626569, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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13
[SID103168639]
Antiviral activity was evaluated in vitro against human poliovirus as inhibition zone in agar-diffusion plaque-inhibition test [AID69267, Type: Literature]
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14
[SID103168639]
Antiviral activity was evaluated in vitro against human poliovirus by agar-diffusion plaque-inhibition test; (- =>inhibition, diameter < = 5 mm) [AID69268, Type: Literature]
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15
[SID103168639]
Antiviral activity was evaluated in vitro against human poliovirus as toxicity zone in agar-diffusion plaque-inhibition test [AID69269, Type: Literature]
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16
[SID103168639]
Inhibition of alpha-MSH -stimulated melanogenesis in mouse B16 cells assessed as melanin release at 10 uM after 72 hrs by spectrometric analysis [AID626571, Type: Literature]
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17
[SID17388694]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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18
[SID144207467]
Potency-Replicate_1 0.0177qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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19
[SID144207467]
Potency-Replicate_1 17.5096qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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20
[SID17388694]
Potency 21.1317qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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