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BioActivity Data for Compound 1-methylnaphthalene (CID 7002)

BioActivity Outcomes:
Active(5)
 
 
Inactive(410)
 
 
Inconclusive(13)
 
 
Unspecified(4)
 
 
Top Targets:
NR LBD PPAR(21)
 
 
 
NR LBD AR(16)
 
 
 
NR LBD ER(16)
 
 
 
NR LBD Fxr(10)
 
 
 
NR LBD GR(10)
 
 
 
BioAssay Types:
Confirmatory(294)
 
 
 
Summary(58)
 
 
 
 
Screening(51)
 
 
Literature(9)
 
 
 
 
BioAssay Categories:
In vivo(1)
 
 
Biochemical(30)
 
 
Toxicity(42)
 
 
 
ADME(6)
 
 
 
Cell-based(19)
 
 
Organism-base..(2)
 
 
BioActivity Types:
Potency(304)
 
 
 
 
IC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 316    Data Row: 432   Total Pages: 22   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103463857]
IC50 23.9883Inhibition of mouse CYP2A5 [AID420670, Type: Literature]Cytochrome P450 2A5 [gi:117196]
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2
[SID103463857]
IC50 24Inhibitory concentration against mouse cytochrome P450 2A5 [AID241174, Type: Literature]
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3
[SID103463857]
IC50 33.9625Inhibition of human CYP2A6 [AID420671, Type: Literature]Cytochrome P450 2A6 [gi:308153612]
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4
[SID103463857]
IC50 34Inhibitory concentration against human cytochrome P450 2A6 [AID241172, Type: Literature]Cytochrome P450 2A6 [gi:308153612]
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5
[SID144208966]
AhR Potency (uM) qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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6
[SID103463857]
IC50 110Inhibitory concentration against recombinant human cytochrome P450 1A2 [AID241334, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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7
[SID103463857]
Octanol-water partition coefficient, log P of the compound [AID603957, Type: Literature]
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8
[SID103463857]
Ratio of IC50 for human CYP2A6 to that of mouse CYP2A5 was determined [AID242975, Type: Literature]
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9
[SID17389821]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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10
[SID17389821]
Potency 5.9557qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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11
[SID17389821]
Potency 39.8107qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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12
[SID144208966]
Potency-Replicate_1 55.7554qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway [AID720691, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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13
[SID17389821]
Potency qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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14
[SID144208966]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the RXR signaling pathway: Summary [AID1159531, Type: summary]retinoid X nuclear receptor alpha [Homo sapiens] [gi:325495497]
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15
[SID144210657]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the RXR signaling pathway: Summary [AID1159531, Type: summary]retinoid X nuclear receptor alpha [Homo sapiens] [gi:325495497]
View
16
[SID144210657]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the RXR signaling pathway [AID1159527, Type: confirmatory]retinoid X nuclear receptor alpha [Homo sapiens] [gi:325495497]
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17
[SID144208966]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the RXR signaling pathway [AID1159527, Type: confirmatory]retinoid X nuclear receptor alpha [Homo sapiens] [gi:325495497]
View
18
[SID17389821]
Potency qHTS assay for small molecule agonists of retinoid X receptor alpha signaling [AID588544, Type: confirmatory]retinoid X nuclear receptor alpha [Homo sapiens] [gi:325495497]
View
19
[SID17389821]
Potency qHTS assay for small molecule antagonists of retinoid X receptor alpha signaling [AID588546, Type: confirmatory]retinoid X nuclear receptor alpha [Homo sapiens] [gi:325495497]
View
20
[SID144208966]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway: Summary [AID743239, Type: summary]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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