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N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)pyrazine-2-carboxamide (CID 697851) - Compound BioActivity Data
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BioActivity Outcomes:
Active(37)
 
 
Inactive(660)
 
 
Inconclusive(27)
 
 
Unspecified(2)
 
 
Top Targets:
7tm 4(44)
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
G-alpha(8)
 
 
 
recC(7)
 
 
 
BioAssay Types:
Screening(475)
 
 
 
 
 
Confirmatory(213)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(148)
 
 
 
 
 
IC50(49)
 
 
 
EC50(9)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 648    Data Row: 726   Total Pages: 37   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17503948]
Potency 5.8048A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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2
[SID17503948]
Potency 6.012qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID17503948]
Potency 9.2qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID17503948]
EC50 9.25A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhimurium identified in the primary screen [AID2253, Type: confirmatory]
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5
[SID17503948]
Potency 10qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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6
[SID17503948]
Potency 11.5821qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID124343027]
IC50 13Late stage assay provider assay for AddAB inhibitors: Radioactivity-based biochemical dose response assay to identify inhibitors of the nuclease activity of purified AddAB [AID602421, Type: confirmatory]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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8
[SID124343027]
IC50 13Late stage assay provider assay for AddAB inhibitors: Radioactivity-based biochemical dose response assay to identify inhibitors of the nuclease activity of purified AddAB [AID602421, Type: confirmatory]recombination protein RecB [Helicobacter pylori 26695] [gi:15646160]
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9
[SID17503948]
Potency 14.1254qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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10
[SID126496932]
IC50 17Late stage assay provider assay for AddAB inhibitors: Radioactivity-based biochemical dose response assay to identify inhibitors of the nuclease activity of purified AddAB [AID602421, Type: confirmatory]recombination protein RecB [Helicobacter pylori 26695] [gi:15646160]
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11
[SID126496932]
IC50 17Late stage assay provider assay for AddAB inhibitors: Radioactivity-based biochemical dose response assay to identify inhibitors of the nuclease activity of purified AddAB [AID602421, Type: confirmatory]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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12
[SID17503948]
Potency 25.1189qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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13
[SID17503948]
Potency 26.6795qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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14
[SID17503948]
Potency 28.1838qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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15
[SID124343027]
IC50 33Late stage assay provider counterscreen for AddAB inhibitors: Radioactivity-based biochemical dose response assay to identify inhibitors of the nuclease activity of purified RecBCD enzyme [AID623920, Type: confirmatory]exonuclease V (RecBCD complex), beta subunit [Escherichia coli str. K-12 substr. MG1655] [gi:16130724]
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16
[SID124343027]
IC50 33Late stage assay provider counterscreen for AddAB inhibitors: Radioactivity-based biochemical dose response assay to identify inhibitors of the nuclease activity of purified RecBCD enzyme [AID623920, Type: confirmatory]exonuclease V (RecBCD complex), gamma chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130726]
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17
[SID126496932]
IC50 42Late stage assay provider counterscreen for AddAB inhibitors: Radioactivity-based biochemical dose response assay to identify inhibitors of the nuclease activity of purified RecBCD enzyme [AID623920, Type: confirmatory]exonuclease V (RecBCD complex), gamma chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130726]
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18
[SID126496932]
IC50 42Late stage assay provider counterscreen for AddAB inhibitors: Radioactivity-based biochemical dose response assay to identify inhibitors of the nuclease activity of purified RecBCD enzyme [AID623920, Type: confirmatory]exonuclease V (RecBCD complex), beta subunit [Escherichia coli str. K-12 substr. MG1655] [gi:16130724]
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19
[SID124343027]
Late stage assay provider counterscreen for AddAB inhibitors: Radioactivity-based biochemical assay to identify inhibitors of the nuclease activity of purified RecBCD enzyme (at 100 micromolar) [AID623921, Type: other]exonuclease V (RecBCD complex), beta subunit [Escherichia coli str. K-12 substr. MG1655] [gi:16130724]
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20
[SID126496932]
Late stage assay provider counterscreen for AddAB inhibitors: Radioactivity-based biochemical assay to identify inhibitors of the nuclease activity of purified RecBCD enzyme (at 100 micromolar) [AID623921, Type: other]exonuclease V (RecBCD complex), beta subunit [Escherichia coli str. K-12 substr. MG1655] [gi:16130724]
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