XCT790 (CID 6918788) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(12)
 
 
Inactive(84)
 
 
Inconclusive(13)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(4)
 
 
PIKKc TOR(4)
 
 
Pyr redox dim(4)
 
 
 
HELICc(3)
 
 
Menin(2)
 
 
BioAssay Types:
Confirmatory(73)
 
 
 
 
Screening(30)
 
 
Literature(6)
 
 
 
 
BioActivity Types:
Potency(74)
 
 
 
 
IC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 105    Data Row: 110   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103456869]
IC50 0.37Inhibition of estrogen-related receptor alpha Gal4 activity [AID241429, Type: Literature]
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2
[SID103456869]
IC50 0.37Antagonist activity at ERRalpha LBD expressed in HEK293 cells assessed as Gal4-SRC2 interaction by two hybrid luciferase reporter gene assay [AID569736, Type: Literature]
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3
[SID29217710]
Potency 6.7016qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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4
[SID29217710]
Potency 6.7016qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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5
[SID90341312]
Potency 7.9433qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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6
[SID90341312]
Potency 7.9433qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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7
[SID90341312]
Potency 8.4368qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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8
[SID29217710]
Potency 8.9125qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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9
[SID29217710]
Potency 8.9125qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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10
[SID90341312]
Potency 10.6213qHTS Validation Assay for the Inhibitors of DNA Replication in Gram-Positive Bacteria [AID485295, Type: confirmatory]DNA polymerase III [Bacillus subtilis] [gi:30027657]
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11
[SID90341312]
Potency 14.575qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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12
[SID90341312]
Potency 18.8876Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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13
[SID90341312]
Potency 18.8876Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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14
[SID90341312]
Potency 18.8876Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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15
[SID90341312]
Potency 23.9341qHTS Validation Assay to Find Inhibitors of Pin1 [AID504536, Type: confirmatory]PIN1 gene product [Homo sapiens] [gi:5453898]
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16
[SID90341312]
Potency 23.9341qHTS Validation Assay to Find Inhibitors of Pin1 [AID504536, Type: confirmatory]PIN1 gene product [Homo sapiens] [gi:5453898]
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17
[SID90341312]
Potency 50.1187Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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18
[SID90341312]
Potency 89.1251qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID488953, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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19
[SID103456869]
 Percent inhibition of estrogen-related receptor alpha Gal4 activity at 10 uM [AID243558, Type: Literature]
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20
[SID90341312]
Potency 2.5928HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators [AID488982, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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21
[SID90341312]
Potency 2.5928HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators [AID488982, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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22
[SID90341312]
Potency 2.5928HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators [AID488982, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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23
[SID90341312]
Potency 2.5928HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators [AID488982, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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24
[SID29217710]
Potency 3.9811qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]MEN1 gene product [Homo sapiens] [gi:18860839]
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25
[SID90341312]
Potency 4.6109qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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26
[SID90341312]
Potency 7.5193qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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27
[SID90341312]
Potency 7.5193qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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28
[SID90341312]
Potency 58.0479qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]NPC1 gene product [Homo sapiens] [gi:255652944]
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29
[SID90341312]
Potency 91.9997qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]RAB9A gene product [Homo sapiens] [gi:4759012]
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30
[SID85844594]
 Luminescence Cell-Based Primary HTS to Identify Compounds which Inhibit A1 Apoptosis [AID2465, Type: screening]bcl-2-like protein 11 isoform 1 [Homo sapiens] [gi:20336315]
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31
[SID85844594]
 Luminescence Cell-Based Primary HTS to Identify Compounds which Inhibit A1 Apoptosis [AID2465, Type: screening]bcl-2-like protein 11 isoform 1 [Homo sapiens] [gi:20336315]
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32
[SID85844594]
 Luminescence Cell-Based Primary HTS to Identify Compounds which Inhibit A1 Apoptosis [AID2465, Type: screening]bcl-2-like protein 11 isoform 1 [Homo sapiens] [gi:20336315]
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33
[SID85844594]
 Luminescence Cell-Based Primary HTS to Identify Compounds which Inhibit A1 Apoptosis [AID2465, Type: screening]bcl-2-like protein 11 isoform 1 [Homo sapiens] [gi:20336315]
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34
[SID85844594]
 Turbidometric Biochemical Primary HTS to identify inhibitors of ERp5 Measured in Biochemical System Using Plate Reader - 7002-01_Inhibitor_SinglePoint_HTS_Activity [AID651711, Type: screening]Protein disulfide-isomerase A6 [gi:2501205]
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35
[SID90341312]
Potency qHTS for Inhibitors of Cell Surface uPA Generation: Validation Assay [AID493164, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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36
[SID90341312]
Potency qHTS for Inhibitors of Cell Surface uPA Generation: Validation Assay [AID493164, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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37
[SID29217710]
Potency VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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38
[SID29217710]
Potency qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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39
[SID85844594]
 MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5 [AID652115, Type: screening]NAD-dependent protein deacylase sirtuin-5, mitochondrial [gi:38258652]
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40
[SID85844594]
 MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5 [AID652115, Type: screening]NAD-dependent protein deacylase sirtuin-5, mitochondrial [gi:38258652]
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41
[SID85844594]
 Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-01_Inhibitor_SinglePoint_HTS_Activity [AID651658, Type: screening]FGF22 gene product [Homo sapiens] [gi:10190672]
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42
[SID85844594]
 S100A4: HTS Measured in Biochemical System Using Plate Reader - 7045-01_Inhibitor_SinglePoint_HTS_Activity [AID652163, Type: screening]S100A4 [Homo sapiens] [gi:47496637]
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43
[SID85844594]
 NSD2 Inhibitors Measured in Biochemical System Using Plate Reader - 2115-01_Inhibitor_SinglePoint_HTS_Activity [AID624260, Type: screening]WHSC1 gene product [Homo sapiens] [gi:109633019]
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44
[SID85844594]
 HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]PAX8 [Homo sapiens] [gi:998701]
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45
[SID85844594]
 Identification of inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_SinglePoint_HTS_Activity [AID602329, Type: screening]RAD54L gene product [Homo sapiens] [gi:216548193]
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46
[SID29217710]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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47
[SID85844594]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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48
[SID85844594]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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49
[SID85844594]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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50
[SID85844594]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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