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XCT790 (CID 6918788) - Compound BioActivity Data
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BioActivity Outcomes:
Active(12)
 
 
Inactive(107)
 
 
Inconclusive(15)
 
 
Unspecified(1)
 
 
Top Targets:
PIKKc TOR(4)
 
 
7TM GPCR Srx(4)
 
 
Pyr redox dim(4)
 
 
 
Hexokinase 2(3)
 
 
SIS(3)
 
 
BioAssay Types:
Confirmatory(90)
 
 
 
 
Screening(36)
 
 
Literature(8)
 
 
 
 
BioActivity Types:
Potency(91)
 
 
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 118    Data Row: 135   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103456869]
IC50 0.37Inhibition of estrogen-related receptor alpha Gal4 activity [AID241429, Type: Literature]
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2
[SID103456869]
IC50 0.37Antagonist activity at ERRalpha LBD expressed in HEK293 cells assessed as Gal4-SRC2 interaction by two hybrid luciferase reporter gene assay [AID569736, Type: Literature]
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3
[SID29217710]
Potency 6.7016qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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4
[SID90341312]
Potency 7.9433qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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5
[SID90341312]
Potency 8.4368qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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6
[SID29217710]
Potency 8.9125qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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7
[SID90341312]
Potency 10.6213qHTS Validation Assay for the Inhibitors of DNA Replication in Gram-Positive Bacteria [AID485295, Type: confirmatory]DNA polymerase III [Bacillus subtilis] [gi:30027657]
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8
[SID90341312]
Potency 14.575qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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9
[SID90341312]
Potency 18.8876Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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10
[SID90341312]
Potency 23.9341qHTS Validation Assay to Find Inhibitors of Pin1 [AID504536, Type: confirmatory]peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Homo sapiens] [gi:5453898]
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11
[SID90341312]
Potency 50.1187Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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12
[SID90341312]
Potency 89.1251qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID488953, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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13
[SID103456869]
Percent inhibition of estrogen-related receptor alpha Gal4 activity at 10 uM [AID243558, Type: Literature]
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14
[SID90341312]
Potency 2.5928HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators [AID488982, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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15
[SID29217710]
Potency 3.9811qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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16
[SID29217710]
Potency 3.9811qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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17
[SID90341312]
Potency 4.6109qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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18
[SID90341312]
Potency 7.5193qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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19
[SID90341312]
Potency 58.0479qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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20
[SID90341312]
Potency 91.9997qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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21
[SID90341312]
Potency Cytometric Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells [AID2660, Type: confirmatory]serine/threonine-protein kinase mTOR [Homo sapiens] [gi:4826730]
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22
[SID90341312]
Potency High Content Imaging Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells [AID2666, Type: confirmatory]serine/threonine-protein kinase mTOR [Homo sapiens] [gi:4826730]
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23
[SID90341312]
Potency High Content Imaging Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF Cells [AID2667, Type: confirmatory]serine/threonine-protein kinase mTOR [Homo sapiens] [gi:4826730]
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24
[SID90341312]
Potency Cytometry Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF cells [AID2668, Type: confirmatory]serine/threonine-protein kinase mTOR [Homo sapiens] [gi:4826730]
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25
[SID85844594]
ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]transforming acidic coiled-coil-containing protein 3 [Homo sapiens] [gi:5454102]
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26
[SID90341312]
Potency qHTS Validation Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101 [AID485342, Type: confirmatory]tumor susceptibility gene 101 protein [Homo sapiens] [gi:5454140]
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27
[SID90341312]
Potency qHTS for Inhibitors of Cell Surface uPA Generation: Validation Assay [AID493164, Type: confirmatory]urokinase-type plasminogen activator precursor [Mus musculus] [gi:6679377]
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28
[SID29217710]
Potency qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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29
[SID90341312]
Potency qHTS for Inhibitors of Cell Surface uPA Generation: Validation Assay [AID493164, Type: confirmatory]urokinase plasminogen activator surface receptor precursor [Mus musculus] [gi:7242179]
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30
[SID29217710]
qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase isoform 1 [Homo sapiens] [gi:7669492]
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31
[SID90341312]
Potency HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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32
[SID90341312]
Potency qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: Diaphorase-coupled assay [AID743205, Type: confirmatory]glucokinase isoform 1 [Homo sapiens] [gi:4503951]
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33
[SID90341312]
Potency qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: ADP-Glo assay [AID743206, Type: confirmatory]glucokinase isoform 1 [Homo sapiens] [gi:4503951]
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34
[SID90341312]
Potency qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: HTRF assay [AID743207, Type: confirmatory]glucokinase isoform 1 [Homo sapiens] [gi:4503951]
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35
[SID29217710]
Potency qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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36
[SID90341312]
Potency qHTS Validation Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1) [AID488816, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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37
[SID85844594]
Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-01_Inhibitor_SinglePoint_HTS_Activity [AID651658, Type: screening]fibroblast growth factor 22 precursor [Homo sapiens] [gi:10190672]
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38
[SID90341312]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488772, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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39
[SID90341312]
Potency qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488773, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
View
40
[SID29217710]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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41
[SID29217710]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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42
[SID29217710]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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43
[SID29217710]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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44
[SID85844594]
NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]nuclear factor NF-kappa-B p105 subunit isoform 1 [Homo sapiens] [gi:34577122]
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45
[SID85844594]
MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5 [AID652115, Type: screening]NAD-dependent protein deacylase sirtuin-5, mitochondrial [gi:38258652]
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46
[SID90341312]
Potency qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails [AID488949, Type: confirmatory]M-phase phosphoprotein 8 [Homo sapiens] [gi:41055989]
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47
[SID90341312]
Potency High-Throughput Screening for Modulators of Cytosolic Chaperonin Activity: MmCpn Primary Screen [AID488978, Type: confirmatory]chaperonin GroEL [Methanococcus maripaludis S2] [gi:45359078]
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48
[SID85844594]
S100A4: HTS Measured in Biochemical System Using Plate Reader - 7045-01_Inhibitor_SinglePoint_HTS_Activity [AID652163, Type: screening]S100A4 [Homo sapiens] [gi:47496637]
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49
[SID29217710]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
View
50
[SID85844594]
Whole cell Yeast HTS to identify compounds modulating the fidelity of the start codon recognition in eukaryotes. Measured in Whole Organism System Using Plate Reader - 2155-01_Other_SinglePoint_HTS_Activity [AID602363, Type: screening]
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