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2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide (CID 6918454) - Compound BioActivity Data
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BioActivity Outcomes:
Active(498)
 
 
Inactive(54)
 
 
Inconclusive(39)
 
 
Unspecified(677)
 
 
Top Targets:
PTKc Abl(16)
 
 
PKc like(13)
 
 
PTKc EGFR(12)
 
 
PI3Kc IA alph..(10)
 
 
STKc RSK N(10)
 
 
 
BioAssay Types:
Confirmatory(647)
 
 
 
 
 
Literature(587)
 
 
 
 
Summary(24)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
IC50(586)
 
 
 
Kd(442)
 
 
 
Potency(93)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1258    Data Row: 1268   Total Pages: 64   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103320975]
IC50 0.002Inhibitory concentration against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assay [AID126772, Type: Literature]
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2
[SID103320975]
IC50 0.0023Inhibition of MEK-mediated phosphorylation of myelin basic protein by kinase cascade assay [AID410377, Type: Literature]
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3
[SID103320975]
IC50 0.00245Inhibition of MEK-mediated ERK phosphorylation in PDGF-stimulated mouse K-Balb cells treated as single oral dose preincubated for 1 hr before PDGF challenge by whole cell assay [AID410378, Type: Literature]
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4
[SID103320975]
IC50 0.0035Inhibition of MEK-stimulated ERK phosphorylation in PDGF-stimulated mouse C26 cells treated as single oral dose before PDGF challenge by whole cell assay [AID410380, Type: Literature]
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5
[SID103320975]
IC50 0.012Inhibition of Raf1 kinase [AID322453, Type: Literature]
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6
[SID103320975]
IC50 0.016Inhibition of MEK assessed as inhibition of ERK phosphorylation by Raf-MEK-ERK cascade assay [AID298460, Type: Literature]
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7
[SID103320975]
IC50 0.02276SANGER: Inhibition of human H9 cell growth in a cell viability assay. [AID742187, Type: confirmatory]
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8
[SID103320975]
IC50 0.02885SANGER: Inhibition of human CHP-212 cell growth in a cell viability assay. [AID742065, Type: confirmatory]
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9
[SID103320975]
IC50 0.0354Inhibition of MEK-mediated ERK phosphorylation in PDGF-stimulated mouse K-Balb cells treated as single oral dose preincubated for 24 hrs before PDGF challenge by whole cell assay [AID410379, Type: Literature]
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10
[SID103320975]
IC50 0.04152SANGER: Inhibition of human EoL-1-cell cell growth in a cell viability assay. [AID742166, Type: confirmatory]
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11
[SID103320975]
IC50 0.046Inhibition of MEK in mouse colon 26 carcinoma cells assessed as inhibition of ERK phosphorylation by ELISA [AID298461, Type: Literature]
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12
[SID103320975]
IC50 0.053Inhibition of MEK in mouse Colon 26 cells by Western blot [AID345052, Type: Literature]
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13
[SID103320975]
IC50 0.07599SANGER: Inhibition of human DU-4475 cell growth in a cell viability assay. [AID742125, Type: confirmatory]
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14
[SID103320975]
IC50 0.10974SANGER: Inhibition of human MMAC-SF cell growth in a cell viability assay. [AID742370, Type: confirmatory]
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15
[SID103320975]
IC50 0.11713SANGER: Inhibition of human AGS cell growth in a cell viability assay. [AID741960, Type: confirmatory]
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16
[SID103320975]
Kd 0.12Binding constant for MEK1 kinase domain [AID624893, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400274]
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17
[SID103320975]
IC50 0.131Inhibitory concentration against LoVo cell proliferation, was determined using Cellular proliferation assays [AID102174, Type: Literature]
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18
[SID103320975]
IC50 0.15468SANGER: Inhibition of human M14 cell growth in a cell viability assay. [AID742336, Type: confirmatory]
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19
[SID103320975]
IC50 0.17254SANGER: Inhibition of human CP50-MEL-B cell growth in a cell viability assay. [AID742083, Type: confirmatory]
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20
[SID103320975]
IC50 0.19072SANGER: Inhibition of human C32 cell growth in a cell viability assay. [AID741994, Type: confirmatory]
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