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leptomycin B (CID 6917907) - Compound BioActivity Data
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BioActivity Outcomes:
Active(5)
 
 
Inactive(2)
 
 
Unspecified(1)
 
 
BioAssay Types:
Literature(8)
 
 
 
 
BioActivity Types:
EC50(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 8    Data Row: 8   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103648834]
EC50 0.00822Inhibition of HIV1 Rev expressed in human HeLa cells co-expressing renilla luciferase reporter gene assessed as inhibition of renilla luciferase expression after 24 hrs [AID582292, Type: Literature]
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2
[SID103648834]
TC50 0.02Inhibition of HIV1 Rev expressed in human HeLa cells co-expressing firefly luciferase reporter gene assessed as inhibition of firefly luciferase expression after 24 hrs [AID582293, Type: Literature]
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3
[SID103648834]
Inhibition of CRM1-mediated nucleocytoplasmic transport of HIV1 RevM5 mutant in human HeLa cells assessed as HIV1 RevM5-GFP nuclear localization at 25 nM after 2 hrs by fluorescence microscopy [AID344805, Type: Literature]
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4
[SID103648834]
Induction of subcellular localization in p27 in african green monkey COS7 cells at 10 ng/ml after 6 hrs by immunofluorescence assay [AID503141, Type: Literature]
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5
[SID103648834]
Induction of subcellular localization in truncated p27 in african green monkey COS7 cells at 10 ng/ml after 6 hrs by immunofluorescence assay [AID503142, Type: Literature]
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6
[SID103648834]
Antiproliferative activity against human PC3 cells at 10 ng/ml after 120 hrs by MTT assay relative to DMSO [AID503322, Type: Literature]
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7
[SID103648834]
Inhibition of Rev-BFP/CRM1-EYFP interaction in human HeLa cells assessed as Rev-BFP/CRM1-EYFP nuclear colocalization by fluorescence microscopy [AID344808, Type: Literature]
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8
[SID103648834]
Inhibition of Rev-BFP/CRM1Cys528Ser-EYFP mutant interaction in human HeLa cells assessed as Rev-BFP/CRM1Cys528Ser-EYFP nuclear colocalization at 25 nM after 2 hrs by fluorescence microscopy [AID344809, Type: Literature]
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