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caffeic acid (CID 689043) - Compound BioActivity Data
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BioActivity Outcomes:
Active(129)
 
 
Inactive(1282)
 
 
Inconclusive(87)
 
 
Unspecified(240)
 
 
Top Targets:
7tm 4(55)
 
 
alkPPc(16)
 
 
 
HELICc(15)
 
 
Tryp SPc(15)
 
 
PLDc mTdp1 2(14)
 
 
 
BioAssay Types:
Confirmatory(637)
 
 
 
 
 
Screening(635)
 
 
 
 
Literature(375)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(477)
 
 
 
 
 
IC50(161)
 
 
 
 
 
EC50(24)
 
 
 
 
Ki(13)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1416    Data Row: 1738   Total Pages: 87   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103198532]
IC50 0.002Antiproliferative activity against human T47D cells after 5 days by MTT assay [AID724462, Type: Literature]
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2
[SID103198532]
IC50 0.01Inhibition of MMP9 in human Hep3B cells using gelatin as substrate [AID735579, Type: Literature]Matrix metalloproteinase-9 [gi:269849668]
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3
[SID103198532]
IC50 0.02122Inhibition of human recombinant MMP9 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 mins [AID735582, Type: Literature]Matrix metalloproteinase-9 [gi:269849668]
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4
[SID103198532]
IC50 0.02426Inhibition of human recombinant MMP2 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 mins [AID735583, Type: Literature]72 kDa type IV collagenase [gi:116856]
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5
[SID103198532]
IC50 0.15Antioxidant activity assessed as DPPH radical scavenging activity after 15 mins by spectrophotometry [AID768168, Type: Literature]
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6
[SID103198532]
IC50 0.19Antihemorrhagic activity in ddY mouse assessed as inhibition of Protobothrops flavoviridis venom-induced hemorrhage incubated with compound for 10 mins measured after 24 hrs [AID592088, Type: Literature]
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7
[SID103198532]
IC50 0.19Antihemorrhagic activity in ddY mouse assessed as inhibition of Protobothrops flavoviridis venom-induced hemorrhagic lesion formation compound incubated with venom for 10 mins and administered subcutaneously measured after 24 hrs [AID631927, Type: Literature]
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8
[SID103198532]
IC50 0.23891Inhibition of human recombinant MMP1 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 mins [AID735584, Type: Literature]Interstitial collagenase [gi:116852]
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9
[SID103198532]
IC50 0.5Compound was evaluated for hydroxyl radical (OH) scavenging activity [AID226669, Type: confirmatory]
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10
[SID855772]
Potency 0.5623qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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11
[SID103198532]
Ki 1.61Inhibition of human CA2 by stopped-flow CO2 hydration assay [AID462271, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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12
[SID855772]
Potency 1.9953qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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13
[SID855772]
Potency 1.9953qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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14
[SID90340699]
Potency 1.9953qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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15
[SID103198532]
IC50 2.2Antioxidant activity assessed as superoxide radical anion scavenging activity [AID287996, Type: Literature]
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16
[SID103198532]
Ki 2.38Inhibition of human CA1 by stopped-flow CO2 hydration assay [AID462270, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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17
[SID103198532]
EC50 2.78Antibacterial activity against Staphylococcus epidermidis [AID283976, Type: Literature]
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18
[SID103198532]
EC50 2.78Antibacterial activity against Staphylococcus aureus [AID283977, Type: Literature]
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19
[SID103198532]
IC50 2.8ABTS radical scavenging activity [AID263927, Type: Literature]
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20
[SID103198532]
IC50 2.8ABTS radical scavenging activity [AID276002, Type: Literature]
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