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caffeic acid (CID 689043) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(116)
 
 
Inactive(1234)
 
 
Inconclusive(77)
 
 
Unspecified(165)
 
 
Top Targets:
7TM GPCR Srx(32)
 
 
7TM GPCR Srsx(22)
 
 
alkPPc(16)
 
 
 
HELICc(15)
 
 
Bromo ALL-1(14)
 
 
 
BioAssay Types:
Screening(632)
 
 
 
 
Confirmatory(629)
 
 
 
 
 
Literature(284)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(475)
 
 
 
 
 
IC50(143)
 
 
 
 
 
EC50(21)
 
 
 
 
Ki(13)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1283    Data Row: 1592   Total Pages: 32   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103198532]
IC50 0.002Antiproliferative activity against human T47D cells after 5 days by MTT assay [AID724462, Type: Literature]
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2
[SID103198532]
IC50 0.01Inhibition of MMP9 in human Hep3B cells using gelatin as substrate [AID735579, Type: Literature]Matrix metalloproteinase-9 [gi:269849668]
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3
[SID103198532]
IC50 0.02122Inhibition of human recombinant MMP9 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 mins [AID735582, Type: Literature]Matrix metalloproteinase-9 [gi:269849668]
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4
[SID103198532]
IC50 0.02426Inhibition of human recombinant MMP2 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 mins [AID735583, Type: Literature]72 kDa type IV collagenase [gi:116856]
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5
[SID103198532]
IC50 0.19Antihemorrhagic activity in ddY mouse assessed as inhibition of Protobothrops flavoviridis venom-induced hemorrhage incubated with compound for 10 mins measured after 24 hrs [AID592088, Type: Literature]
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6
[SID103198532]
IC50 0.19Antihemorrhagic activity in ddY mouse assessed as inhibition of Protobothrops flavoviridis venom-induced hemorrhagic lesion formation compound incubated with venom for 10 mins and administered subcutaneously measured after 24 hrs [AID631927, Type: Literature]
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7
[SID103198532]
IC50 0.23891Inhibition of human recombinant MMP1 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 mins [AID735584, Type: Literature]Interstitial collagenase [gi:116852]
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8
[SID103198532]
IC50 0.5Compound was evaluated for hydroxyl radical (OH) scavenging activity [AID226669, Type: other]
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9
[SID855772]
Potency 0.5623qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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10
[SID103198532]
Ki 1.61Inhibition of human CA2 by stopped-flow CO2 hydration assay [AID462271, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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11
[SID90340699]
Potency 1.9953qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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12
[SID855772]
Potency 1.9953qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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13
[SID855772]
Potency 1.9953qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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14
[SID103198532]
IC50 2.2Antioxidant activity assessed as superoxide radical anion scavenging activity [AID287996, Type: Literature]
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15
[SID103198532]
Ki 2.38Inhibition of human CA1 by stopped-flow CO2 hydration assay [AID462270, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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16
[SID103198532]
EC50 2.78Antibacterial activity against Staphylococcus epidermidis [AID283976, Type: Literature]
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17
[SID103198532]
EC50 2.78Antibacterial activity against Staphylococcus aureus [AID283977, Type: Literature]
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18
[SID103198532]
IC50 2.8ABTS radical scavenging activity [AID276002, Type: Literature]
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19
[SID103198532]
IC50 2.8ABTS radical scavenging activity [AID263927, Type: Literature]
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20
[SID103198532]
IC50 2.8Inhibition of HIV1 integrase in presence of Mn2+ [AID362190, Type: Literature]
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21
[SID103198532]
IC50 2.8Inhibition of HIV1 integrase by overall integration assay [AID362184, Type: Literature]
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22
[SID103198532]
IC50 2.9Superoxide anion radical scavenging activity by xanthine/xanthine oxidase method [AID276003, Type: Literature]
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23
[SID103198532]
IC50 2.9Superoxide radical scavenging activity [AID263926, Type: Literature]
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24
[SID103198532]
IC50 3In vitro inhibitory activity against 5-lipoxygenase obtained from potato [AID254899, Type: Literature]
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25
[SID103198532]
IC50 3Inhibitory activity against potato 5LOX [AID261406, Type: Literature]5-lipoxygenase [gi:75278003]
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26
[SID103198532]
IC50 3.06Inhibition of human recombinant PTP1B after 10 mins [AID467251, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
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27
[SID50104061]
Potency 3.1623qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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28
[SID103198532]
IC50 3.3Evaluated for the antioxidant property by measuring the inhibition of microsomal lipid peroxidation [AID125798, Type: Literature]
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29
[SID103198532]
IC50 3.47Inhibition of potato LOX5 by enzyme immuno assay [AID410035, Type: Literature]
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30
[SID103198532]
IC50 3.7Antioxidant activity assessed as DPPH radical scavenging activity [AID287995, Type: Literature]
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31
[SID103198532]
IC50 4Inhibition of potato 5-LOX by EIA [AID657245, Type: Literature]
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32
[SID103198532]
IC50 4Inhibition of potato 5LOX by enzyme immunoassay [AID393821, Type: Literature]
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33
[SID103198532]
IC50 4Inhibition of potato LOX5 [AID368227, Type: Literature]
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34
[SID103198532]
IC50 4Inhibition of potato tuber 5LOX by polarographic method [AID461096, Type: Literature]
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35
[SID103198532]
IC50 4Inhibition of potato 5-Lipoxygenase by enzyme immuno assay [AID461114, Type: Literature]
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36
[SID103198532]
IC50 4Inhibition of potato 5LOX by enzyme immuno assay [AID474249, Type: Literature]
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37
[SID103198532]
IC50 4Inhibition of potato 5-LOX after 5 mins by enzyme immuno assay [AID443728, Type: Literature]5-lipoxygenase [gi:75278003]
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38
[SID103198532]
IC50 4.5Inhibition of potato 5-LOX assessed as hydroperoxides production by EIA [AID578497, Type: Literature]
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39
[SID103198532]
IC50 5.37Antioxidant activity assessed as ABTS radical scavenging activity after 6 mins by cation decolorization assay [AID427136, Type: Literature]
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40
[SID103198532]
IC50 5.7Antioxidant activity of the compound assessed as DPPH radical scavenging activity after 60 mins [AID690970, Type: Literature]
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41
[SID103198532]
Ki 6.42Inhibition of human CA7 by stopped-flow CO2 hydration assay [AID462277, Type: Literature]Carbonic anhydrase 7 [gi:1168744]
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42
[SID103198532]
Ki 6.49Inhibition of human CA5A by stopped-flow CO2 hydration assay [AID462274, Type: Literature]Carbonic anhydrase 5A, mitochondrial [gi:461680]
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43
[SID855772]
IC50 6.76A biochemical assay using the ADP-Hunter methodology, purified TAg, and ATP to identify compounds that inhibit the ATPase activity of Tag - Counter Screen [AID2501, Type: confirmatory]
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44
[SID26751505]
Potency 7.0795qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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45
[SID855772]
IC50 7.3Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents [AID1903, Type: confirmatory]large T antigen [Simian virus 40] [gi:297591903]
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46
[SID103198532]
Ki 7.33Inhibition of human CA6 by stopped-flow CO2 hydration assay [AID462276, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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47
[SID103198532]
Ki 7.87Inhibition of human CA9 by stopped-flow CO2 hydration assay [AID462278, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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48
[SID855772]
Potency 7.9433qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen [AID2100, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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49
[SID103198532]
Ki 8.71Inhibition of human CA14 by stopped-flow CO2 hydration assay [AID462281, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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50
[SID103198532]
Ki 9.06Inhibition of human CA12 by stopped-flow CO2 hydration assay [AID462279, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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