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SANT-1 (CID 6878030) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(129)
 
 
Inconclusive(7)
 
 
Unspecified(3)
 
 
Top Targets:
HSD10-like SD..(4)
 
 
Pyr redox dim(4)
 
 
PIKKc TOR(4)
 
 
7TM GPCR Srx(4)
 
 
P53(3)
 
 
BioAssay Types:
Confirmatory(125)
 
 
 
 
Screening(11)
 
 
Literature(9)
 
 
 
 
BioActivity Types:
Potency(123)
 
 
 
 
IC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 134    Data Row: 145   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103596001]
IC50 0.00474Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay [AID494009, Type: Literature]
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2
[SID103596001]
IC50 0.02Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assay [AID351761, Type: Literature]Sonic hedgehog protein [gi:6094284]
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3
[SID103596001]
IC50 0.025Inhibition of Smoothened transfected in HEK293 cells by binding assay [AID494010, Type: Literature]
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4
[SID26753181]
Potency 10qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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5
[SID90341472]
Potency 16.8336qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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6
[SID90341472]
Potency 39.8107qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID488953, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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7
[SID103596001]
Lipophilicity, log D of the compound [AID453203, Type: Literature]
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8
[SID103596001]
Permeability in human skin after 48 hrs by Franz cell permeability assay [AID453204, Type: Literature]
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9
[SID103596001]
Inhibition of hair growth in C3H/HeN mouse model assessed as inhibition of hair growth after 14 days [AID494011, Type: Literature]
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10
[SID90341472]
Potency 3.6624HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators [AID488982, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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11
[SID26753181]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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12
[SID26753181]
Potency 17.7828qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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13
[SID26753181]
Potency 19.9526qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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14
[SID90341472]
Potency qHTS for Inhibitors of ATXN expression: Validation [AID588378, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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15
[SID90341472]
Potency qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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16
[SID85787638]
EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Reader - 2125-01_Inhibitor_SinglePoint_HTS_Activity [AID651548, Type: screening]histone-lysine N-methyltransferase EZH2 isoform a [Homo sapiens] [gi:21361095]
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17
[SID90341472]
Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504810, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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18
[SID90341472]
Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504812, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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19
[SID90341472]
Potency qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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20
[SID90341472]
Potency qHTS for Inhibitors of Cell Surface uPA Generation: Validation Assay [AID493164, Type: confirmatory]plasminogen precursor [Mus musculus] [gi:257471003]
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