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AK-968/41025379 (CID 6874905) - Compound BioActivity Data
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BioActivity Outcomes:
Active(111)
 
 
Inactive(655)
 
 
Inconclusive(41)
 
 
Unspecified(2)
 
 
Top Targets:
7tm 4(43)
 
 
Bcl-2 like(16)
 
 
 
alkPPc(12)
 
 
UBCc(9)
 
 
 
G-alpha(8)
 
 
BioAssay Types:
Screening(524)
 
 
 
 
 
Confirmatory(262)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(160)
 
 
 
 
 
IC50(87)
 
 
 
EC50(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 713    Data Row: 809   Total Pages: 41   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17409043]
Potency 0.5358qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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2
[SID56373716]
IC50_Mean 1.38SAR analysis of the MOA of E2 SUMOylation inhibitors in an HTRF format [AID485393, Type: confirmatory]SUMO-conjugating enzyme UBC9 [Homo sapiens] [gi:4507785]
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3
[SID56373716]
IC50_Mean 1.38SAR analysis of the MOA of E2 SUMOylation inhibitors in an HTRF format [AID485393, Type: confirmatory]SUMO1 activating enzyme subunit 1 [Homo sapiens] [gi:17390638]
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4
[SID56373716]
IC50_Mean 1.38SAR analysis of the MOA of E2 SUMOylation inhibitors in an HTRF format [AID485393, Type: confirmatory]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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5
[SID17409043]
IC50 1.66718Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors [AID1417, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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6
[SID85256229]
IC50_Mean 1.83SAR analysis of the MOA of E2 SUMOylation inhibitors in an HTRF format [AID485393, Type: confirmatory]SUMO-conjugating enzyme UBC9 [Homo sapiens] [gi:4507785]
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7
[SID85256229]
IC50_Mean 1.83SAR analysis of the MOA of E2 SUMOylation inhibitors in an HTRF format [AID485393, Type: confirmatory]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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8
[SID85256229]
IC50_Mean 1.83SAR analysis of the MOA of E2 SUMOylation inhibitors in an HTRF format [AID485393, Type: confirmatory]SUMO1 activating enzyme subunit 1 [Homo sapiens] [gi:17390638]
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9
[SID17409043]
Potency 2.2387qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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10
[SID17409043]
IC50 2.253TR-FRET counterscreen for FAK inhibitors: dose-response biochemical high throughput screening assay to identify inhibitors of Proline-rich tyrosine kinase 2 (Pyk2) [AID1641, Type: confirmatory]PTK2B protein tyrosine kinase 2 beta [Homo sapiens] [gi:34784998]
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11
[SID17409043]
IC50 3.18Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2073, Type: confirmatory]voltage-dependent N-type calcium channel subunit alpha-1B isoform 1 [Homo sapiens] [gi:4502523]
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12
[SID17409043]
IC50 3.18Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2073, Type: confirmatory]Mint1 [Rattus norvegicus] [gi:2625023]
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13
[SID17409043]
Absolute IC50 3.61Dose Response Confirmation for Small Molecule Inhibitors of Epstein-Barr Virus [AID1419, Type: confirmatory]BZLF2 [Human herpesvirus 4 type 2] [gi:139424501]
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14
[SID17409043]
IC50 3.847TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID1053172, Type: confirmatory]integrase, partial [Human immunodeficiency virus 1] [gi:2853980]
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15
[SID17409043]
IC50 3.847TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID1053172, Type: confirmatory]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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16
[SID17409043]
Potency 4.4668qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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17
[SID85256229]
IC50_Mean 4.79SAR analysis of small molecule inhibitors of Mint-PDZ and N-type Ca2+ channel carboxyl-terminal peptide association using HTRF - Set 2 [AID434980, Type: confirmatory]voltage-dependent N-type calcium channel subunit alpha-1B isoform 1 [Homo sapiens] [gi:4502523]
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18
[SID85256229]
IC50_Mean 4.79SAR analysis of small molecule inhibitors of Mint-PDZ and N-type Ca2+ channel carboxyl-terminal peptide association using HTRF - Set 2 [AID434980, Type: confirmatory]Mint1 [Rattus norvegicus] [gi:2625023]
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19
[SID17409043]
IC50 4.81Dose response confirmation of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID602386, Type: confirmatory]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
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20
[SID17409043]
Potency 5.6234qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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