BRN 5958195 (CID 686254) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(4)
 
 
Inactive(695)
 
 
Inconclusive(11)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
alkPPc(16)
 
 
Bcl-2 like(11)
 
 
Tryp SPc(11)
 
 
7TM GPCR Srsx(8)
 
 
BioAssay Types:
Screening(471)
 
 
 
 
 
Confirmatory(218)
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(148)
 
 
 
 
IC50(42)
 
 
EC50(12)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 713    Data Row: 713   Total Pages: 15   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID7975695]
 Allosteric Modulators of D1 Receptors: Primary Screen [AID641, Type: screening]
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2
[SID7975695]
 Allosteric Modulators of D1 Receptors: Confirmation Screen [AID642, Type: other]
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3
[SID7975695]
 Primary cell-based high-throughput screening assay to measure PERK inhibition [AID1416, Type: screening]eukaryotic translation initiation factor 2-alpha kinase 3 [Homo sapiens] [gi:134304838]
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4
[SID7975695]
 Primary cell-based high-throughput screening assay to measure PERK inhibition [AID1416, Type: screening]eukaryotic translation initiation factor 2-alpha kinase 3 [Homo sapiens] [gi:134304838]
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5
[SID7975695]
 Allosteric Modulators of D1 Receptors: Secondary Assay 2 [AID647, Type: other]
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6
[SID7975695]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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7
[SID7975695]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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8
[SID7975695]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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9
[SID7975695]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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10
[SID7975695]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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11
[SID7975695]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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12
[SID7975695]
EC50 55.7Dose response cell-based high-throughput screening assay to measure PERK inhibition [AID1522, Type: confirmatory]eukaryotic translation initiation factor 2-alpha kinase 3 [Homo sapiens] [gi:134304838]
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13
[SID7975695]
EC50 55.7Dose response cell-based high-throughput screening assay to measure PERK inhibition [AID1522, Type: confirmatory]eukaryotic translation initiation factor 2-alpha kinase 3 [Homo sapiens] [gi:134304838]
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14
[SID7975695]
EC50 55.7Counterscreen assay for PERK inhibitors: Dose response cell-based high throughput screening assay to measure inhibition of PERK at 6 hours [AID1528, Type: confirmatory]eukaryotic translation initiation factor 2-alpha kinase 3 [Homo sapiens] [gi:134304838]
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15
[SID7975695]
EC50 55.7Counterscreen assay for PERK inhibitors: Dose response cell-based high throughput screening assay to measure inhibition of PERK at 6 hours [AID1528, Type: confirmatory]eukaryotic translation initiation factor 2-alpha kinase 3 [Homo sapiens] [gi:134304838]
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16
[SID7975695]
Potency 89.1251HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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17
[SID7975695]
Potency qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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18
[SID7975695]
Potency qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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19
[SID7975695]
IC50 HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1 [AID432, Type: confirmatory]Bcl2a1a gene product [Mus musculus] [gi:11024684]
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20
[SID7975695]
 HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress [AID2732, Type: screening]Ddit3 gene product [Mus musculus] [gi:160707929]
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21
[SID7975695]
 uHTS for Small Molecule Inhibitors of Eukaryotic Translation Initiation [AID782, Type: screening]eukaryotic translation initiation factor 4E [Mus musculus] [gi:83627717]
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22
[SID7975695]
 uHTS for Small Molecule Inhibitors of Eukaryotic Translation Initiation [AID782, Type: screening]eukaryotic translation initiation factor 4E [Mus musculus] [gi:83627717]
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23
[SID7975695]
 Activator for delta FosB/delta FosB homodimer Measured in Biochemical System Using Plate Reader - 2072-01_Activator_SinglePoint_HTS_Activity [AID493131, Type: screening]protein fosB [Mus musculus] [gi:6679827]
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24
[SID7975695]
 uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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25
[SID7975695]
 uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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26
[SID7975695]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). [AID2098, Type: screening]Hsf1 protein [Mus musculus] [gi:62740231]
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27
[SID7975695]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). [AID2098, Type: screening]Hsf1 protein [Mus musculus] [gi:62740231]
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28
[SID7975695]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) [AID624169, Type: screening]Htr2a gene product [Mus musculus] [gi:27753985]
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29
[SID7975695]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) [AID624169, Type: screening]Htr2a gene product [Mus musculus] [gi:27753985]
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30
[SID7975695]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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31
[SID7975695]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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32
[SID7975695]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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33
[SID7975695]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID1672, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
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34
[SID7975695]
IC50 Fluorescence for the identification of compounds that decrease p/CIP protein stability [AID1984, Type: confirmatory]nuclear receptor coactivator 3 [Mus musculus] [gi:118026946]
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35
[SID7975695]
 Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R1A (PKA-R1A) complex [AID504707, Type: screening]cAMP-dependent protein kinase catalytic subunit beta isoform 1 [Mus musculus] [gi:6755076]
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36
[SID7975695]
Potency qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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37
[SID7975695]
Potency qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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38
[SID7975695]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the prolyl oligopeptidase-like enzyme (PREPL) [AID2751, Type: screening]Prolyl endopeptidase-like [Homo sapiens] [gi:153217451]
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39
[SID7975695]
 Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_SinglePoint_HTS_Activity [AID504523, Type: screening]KEAP1 gene product [Homo sapiens] [gi:45269145]
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40
[SID7975695]
 Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_SinglePoint_HTS_Activity [AID504523, Type: screening]KEAP1 gene product [Homo sapiens] [gi:45269145]
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41
[SID7975695]
 TR-FRET-based primary biochemical high throughput screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3). [AID2300, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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42
[SID7975695]
 TR-FRET-based primary biochemical high throughput screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3). [AID2300, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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43
[SID7975695]
 TR-FRET-based primary biochemical high throughput screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3). [AID2300, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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44
[SID7975695]
 Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID602229, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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45
[SID7975695]
 Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID602229, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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46
[SID7975695]
 Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID602229, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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47
[SID7975695]
 Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B. [AID951, Type: screening]Bcl-2-like protein 10 [gi:23396469]
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48
[SID7975695]
 Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B. [AID951, Type: screening]Bcl-2-like protein 10 [gi:23396469]
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49
[SID7975695]
 Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B. [AID951, Type: screening]Bcl-2-like protein 10 [gi:23396469]
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50
[SID7975695]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of A1 Apoptosis. [AID2462, Type: screening]bcl-2-like protein 11 isoform 1 [Homo sapiens] [gi:20336315]
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