SMR000108096 (CID 6860057) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(51)
 
 
Inactive(679)
 
 
Inconclusive(39)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
alkPPc(14)
 
 
7TM GPCR Srsx(11)
 
 
 
Bcl-2 like(11)
 
 
Tryp SPc(10)
 
 
BioAssay Types:
Screening(514)
 
 
 
 
Confirmatory(236)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(147)
 
 
 
 
 
IC50(50)
 
 
 
 
EC50(12)
 
 
AC50(3)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 766    Data Row: 771   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID7975125]
AC50 3.411Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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2
[SID7975125]
AC50 4.046ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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3
[SID7975125]
IC50 4.28Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay [AID602464, Type: confirmatory]Gli1 [Mus musculus] [gi:6009644]
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4
[SID7975125]
IC50 4.28Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay [AID602464, Type: confirmatory]Gli1 [Mus musculus] [gi:6009644]
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5
[SID7975125]
IC50 4.85XBP1 DR counterscreen for CHOP [AID504313, Type: confirmatory]XBP1 [Homo sapiens] [gi:47678753]
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6
[SID7975125]
IC50 4.88CHOP dose-response primary assay [AID504322, Type: confirmatory]Ddit3 gene product [Mus musculus] [gi:160707929]
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7
[SID7975125]
IC50 6.57Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay [AID651570, Type: confirmatory]Wnt3a gene product [Mus musculus] [gi:7106447]
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8
[SID7975125]
IC50 6.57Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay [AID651570, Type: confirmatory]Wnt3a gene product [Mus musculus] [gi:7106447]
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9
[SID7975125]
Potency 10qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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10
[SID7975125]
Potency 10qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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11
[SID7975125]
Potency 11.2202qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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12
[SID7975125]
Potency 11.2202qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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13
[SID7975125]
Potency 12.5893qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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14
[SID7975125]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID7975125]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID7975125]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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17
[SID7975125]
IC50 16.3Dose response validation of uHTS antagonist hits from Gli-SUFU in a luminescent cytotoxicity assay [AID651569, Type: confirmatory]
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18
[SID7975125]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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19
[SID7975125]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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20
[SID7975125]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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21
[SID7975125]
Potency 56.2341qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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22
[SID7975125]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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23
[SID7975125]
 uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay [AID602449, Type: screening]
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24
[SID7975125]
 Single concentration confirmation of uHTS inhibitor hits of the mitochondrial permeability transition pore via a fluorescent based assay [AID624504, Type: screening]
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25
[SID7975125]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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26
[SID7975125]
 Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based assay to identify antagonists of the parental CHO cell line [AID463079, Type: screening]
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27
[SID7975125]
 Screening for Modulators of Post-Golgi Transport, Control Strain [AID738, Type: screening]
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28
[SID7975125]
 High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression - Pilot Screen [AID823, Type: screening]
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29
[SID7975125]
 High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor - Pilot Screen [AID824, Type: screening]
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30
[SID7975125]
 Leishmania major promastigote HTS [AID1063, Type: screening]
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31
[SID7975125]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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32
[SID7975125]
 Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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33
[SID7975125]
 Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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34
[SID7975125]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]CHRM1 gene product [Homo sapiens] [gi:37622910]
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35
[SID7975125]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]CHRM1 gene product [Homo sapiens] [gi:37622910]
View
36
[SID7975125]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624125, Type: screening]CHRM4 gene product [Homo sapiens] [gi:52426748]
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37
[SID7975125]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624125, Type: screening]CHRM4 gene product [Homo sapiens] [gi:52426748]
View
38
[SID7975125]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624125, Type: screening]CHRM4 gene product [Homo sapiens] [gi:52426748]
View
39
[SID7975125]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624040, Type: screening]CHRM5 gene product [Homo sapiens] [gi:7108336]
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40
[SID7975125]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624040, Type: screening]CHRM5 gene product [Homo sapiens] [gi:7108336]
View
41
[SID7975125]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624040, Type: screening]CHRM5 gene product [Homo sapiens] [gi:7108336]
View
42
[SID7975125]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624040, Type: screening]CHRM5 gene product [Homo sapiens] [gi:7108336]
View
43
[SID7975125]
 Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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44
[SID7975125]
 Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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45
[SID7975125]
 Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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46
[SID7975125]
 Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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47
[SID7975125]
 Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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48
[SID7975125]
 Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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49
[SID7975125]
 Dose Response Assays for S1P1 Agonists and Agonism Potentiators - Potentiator Assay 60K MLSMR [AID466, Type: confirmatory]S1PR1 gene product [Homo sapiens] [gi:13027636]
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50
[SID7975125]
 Dose Response Assays for S1P1 Agonists and Agonism Potentiators - Potentiator Assay 60K MLSMR [AID466, Type: confirmatory]S1PR1 gene product [Homo sapiens] [gi:13027636]
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