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SMR000108096 (CID 6860057) - Compound BioActivity Data
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BioActivity Outcomes:
Active(54)
 
 
Inactive(777)
 
 
Inconclusive(43)
 
 
Unspecified(2)
 
 
Top Targets:
7tm 4(49)
 
 
 
alkPPc(14)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(584)
 
 
 
 
Confirmatory(264)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(169)
 
 
 
 
 
IC50(55)
 
 
 
 
EC50(12)
 
 
AC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 801    Data Row: 876   Total Pages: 44   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID7975125]
AC50_uM 3.411Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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2
[SID7975125]
AC50_uM 4.046ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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3
[SID7975125]
IC50_Mean 4.28Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay [AID602464, Type: confirmatory]Gli1 [Mus musculus] [gi:6009644]
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4
[SID7975125]
Absolute IC50 (XBP1) 4.85XBP1 DR counterscreen for CHOP [AID504313, Type: confirmatory]XBP1 [Homo sapiens] [gi:47678753]
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5
[SID7975125]
Absolute IC50 (CHOP) 4.88CHOP dose-response primary assay [AID504322, Type: confirmatory]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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6
[SID7975125]
IC50_Mean 6.57Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay [AID651570, Type: confirmatory]protein Wnt-3a precursor [Mus musculus] [gi:7106447]
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7
[SID7975125]
Potency 10qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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8
[SID7975125]
Potency 11.2202qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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9
[SID7975125]
Potency 12.5893qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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10
[SID7975125]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID7975125]
IC50_Mean 16.3Dose response validation of uHTS antagonist hits from Gli-SUFU in a luminescent cytotoxicity assay [AID651569, Type: confirmatory]
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12
[SID7975125]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID7975125]
Potency 56.2341qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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14
[SID7975125]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624125, Type: screening]muscarinic acetylcholine receptor M4 [Homo sapiens] [gi:52426748]
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15
[SID7975125]
Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3): Luminescence-based cell-based high throughput screening assay to identify agonists of the Herpes Virus Virion Protein 16 (VP16) [AID624379, Type: screening]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
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16
[SID7975125]
Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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17
[SID7975125]
Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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18
[SID7975125]
Primary Cell-based High Throughput Screening assay for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID561, Type: screening]Nuclear receptor ROR-alpha [gi:548814]
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19
[SID7975125]
Dose-response cell-based assay for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID610, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
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20
[SID7975125]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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