Miconazole (CID 68553) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(69)
 
 
Inactive(802)
 
 
Inconclusive(92)
 
 
Unspecified(58)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
alkPPc(14)
 
 
7TM GPCR Srsx(12)
 
 
 
Bcl-2 like(11)
 
 
Tryp SPc(11)
 
 
BioAssay Types:
Screening(544)
 
 
 
 
 
Confirmatory(344)
 
 
 
 
 
Literature(34)
 
 
 
 
 
BioActivity Types:
Potency(197)
 
 
 
 
 
IC50(47)
 
 
 
 
EC50(13)
 
 
 
AC50(7)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 965    Data Row: 1021   Total Pages: 21   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56422501]
AC50 0.195HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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2
[SID56422501]
AC50 0.195HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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3
[SID56422501]
AC50 0.195HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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4
[SID56422501]
AC50 0.195Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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5
[SID26748144]
Potency 0.3981qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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6
[SID26748144]
Potency 0.3981qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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7
[SID26748144]
Potency 0.3981qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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8
[SID56422501]
AbsAC35_uM 1.2Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (3D7 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-05_Inhibitor_Dose_CherryPick_Activity [AID652047, Type: confirmatory]
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9
[SID56422501]
AbsAC35_uM 1.57Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (HB3 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-06_Inhibitor_Dose_CherryPick_Activity [AID652041, Type: confirmatory]
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10
[SID855623]
Potency 1.6511Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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11
[SID855623]
Potency 2.0787Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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12
[SID855623]
AC50 2.742Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity [AID449749, Type: confirmatory]replicative DNA helicase [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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13
[SID855623]
IC50 2.846High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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14
[SID855623]
Potency 3.5481qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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15
[SID56422501]
AC50 6.36Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Cancer Stem Cells [AID449748, Type: confirmatory]
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16
[SID56422501]
AC50 6.471Dose Response HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP [AID463074, Type: confirmatory]
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17
[SID855623]
AC50 6.549Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity [AID449750, Type: confirmatory]replicative DNA helicase [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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18
[SID855623]
EC50 7.45Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7K cells) [AID431, Type: confirmatory]
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19
[SID26748144]
Potency 7.9433qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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20
[SID855623]
EC50 8.19Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7 cells) [AID430, Type: confirmatory]
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21
[SID855623]
EC50 9.63Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]DNA recombination protein RecA [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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22
[SID855623]
Potency 11.5821A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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23
[SID56422501]
Potency 11.5821qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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24
[SID855623]
Potency 12.5893qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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25
[SID56422501]
Potency 12.9953qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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26
[SID56422501]
Potency 15.8489qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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27
[SID56422501]
Potency 18.3564qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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28
[SID855623]
Potency 22.3872qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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29
[SID855623]
EC50 23.61Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]DNA recombination protein RecA [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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30
[SID855623]
Potency 35.4813qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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31
[SID56422501]
 Counter screen assay for identification of compounds that inhibit the two-pore domain potassium channel KCNK3 [Primary Screening] in non-induced KCNK3 cells [AID651747, Type: screening]
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32
[SID855623]
 Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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33
[SID855623]
 Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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34
[SID855623]
 Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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35
[SID855623]
 Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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36
[SID56422501]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
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37
[SID103580978]
IC50 Antiviral activity against JC polyomavirus M1/SVEdelta infected in human SVG-A cells assessed as inhibition of viral replication after 3 days [AID558029, Type: Literature]
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38
[SID103580978]
 Drug concentration in human plasma [AID558031, Type: Literature]
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39
[SID103580978]
 Cytotoxicity against human SVG-A cells [AID558037, Type: Literature]
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40
[SID103580978]
 Antifungal activity against Candida albicans CGMCC 2.2086 after 24 hrs by turbidimetric method [AID623564, Type: Literature]
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41
[SID103580978]
 Antifungal activity against Ustilago violacea at 50 ug by agar diffusion assay [AID355378, Type: Literature]
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42
[SID56422501]
 Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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43
[SID855623]
 Primary Antimicrobial Assay for E. coli BW25113 ∆tolC::kan Protocol for 384-well HTS [AID573, Type: screening]
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44
[SID855623]
 Human Endothelial Cell Proliferation Assay [AID575, Type: screening]
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45
[SID855623]
 Isolation of Inhibitors of Her-Kinase Expression [AID461, Type: screening]
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46
[SID562772]
 NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line [AID129, Type: confirmatory]
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47
[SID855623]
 Human A549 Lung Tumor Cell Growth Inhibition Assay [AID371, Type: screening]
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48
[SID855623]
 Leishmania major promastigote HTS [AID1063, Type: screening]
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49
[SID855623]
 Screen for Chemicals that Shorten Yeast Lifespan [AID804, Type: screening]
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50
[SID855623]
 Antimicrobial Assay for E. coli BW25113 (wild type) - DR [AID638, Type: confirmatory]
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