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pinocembrin (CID 68071) - Compound BioActivity Data
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BioActivity Outcomes:
Active(11)
 
 
Inactive(473)
 
 
Inconclusive(2)
 
 
Unspecified(84)
 
 
Top Targets:
7tm 4(26)
 
 
TRP 2(5)
 
 
Esterase lipa..(5)
 
 
CAP ED(5)
 
 
PAS(5)
 
 
 
 
BioAssay Types:
Screening(357)
 
 
 
Literature(111)
 
 
 
 
 
Confirmatory(90)
 
 
 
 
BioActivity Types:
Potency(72)
 
 
 
IC50(30)
 
 
 
 
 
EC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 528    Data Row: 570   Total Pages: 29   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103556080]
IC50 0.9Inhibition of aromatase (unknown origin) [AID1077761, Type: confirmatory]Aromatase [gi:117293]
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2
[SID103556080]
IC50 1.491Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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3
[SID103556080]
IC50 1.679Inhibition of human CYP1B1 by EROD assay [AID502475, Type: Literature]Cytochrome P450 1B1 [gi:48429256]
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4
[SID103556080]
ED50 2.87Inhibition of chymotrypsin-like activity of purified human 20S proteasome in HL60 cells using N-succinyl-Leu-Leu-Val-Tyr-AMC as substrate pre-incubated for 10 mins by fluorimetric assay [AID623567, Type: Literature]
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5
[SID103556080]
IC50 7.906Inhibition of human CYP1A1 by EROD assay [AID502474, Type: Literature]Cytochrome P450 1A1 [gi:117139]
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6
[SID103556080]
IC50 18.1Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay [AID756490, Type: Literature]
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7
[SID103556080]
Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay [AID469802, Type: Literature]
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8
[SID103556080]
Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay [AID469799, Type: Literature]
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9
[SID103556080]
Effect on AhR-mediated CYP1A1 activation in mouse Hepa1c1c12 cells at 20 uM after 18 hrs by Western blot analysis [AID431868, Type: Literature]Aryl hydrocarbon receptor [gi:29337198]
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10
[SID103556080]
Effect on AhR-mediated NAPDH quinine reductase activation in mouse Hepa1c1c12 cells at 20 uM after 18 hrs by Western blot analysis [AID431869, Type: Literature]Aryl hydrocarbon receptor [gi:29337198]
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11
[SID103556080]
Induction of nuclear translocation of AhR from cytosol in mouse Hepa1 cells at 20 uM after 60 mins using DAPI staining by microscopic analysis [AID431870, Type: Literature]Aryl hydrocarbon receptor [gi:29337198]
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12
[SID103556080]
IC50 10Cytotoxicity against human HeLa cells by MTT assay [AID423636, Type: Literature]
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13
[SID103556080]
ED50 20Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay [AID623565, Type: Literature]
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14
[SID103556080]
ED50 20Induction of apoptosis in human HT-29 cells assessed reduction of mitochondrial membrane potential after 2 hrs by using JC1 staining by fluorescence cell-based assay [AID623566, Type: Literature]
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15
[SID103556080]
EC50 68Antiproliferative activity against mouse B16-BL6 cells after 72 hrs by MTT assay [AID334275, Type: Literature]
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16
[SID103556080]
IC50 71Cytotoxicity against mouse Colon 26-L5 cells after 72 hrs by MTT assay [AID470665, Type: Literature]
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17
[SID103556080]
IC50 72.8Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay [AID470662, Type: Literature]
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18
[SID103556080]
EC50 75.6Antiproliferative activity against mouse 26-L5 cells after 72 hrs by MTT assay [AID334279, Type: Literature]
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19
[SID103556080]
EC50 92.4Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay [AID334276, Type: Literature]
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20
[SID103556080]
IC50 95.53Cytotoxicity against human NCI-H187 cells after 5 days by Resazurin Microplate Assay [AID480467, Type: Literature]
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