pinocembrin (CID 68071) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(9)
 
 
Inactive(392)
 
 
Inconclusive(2)
 
 
Unspecified(58)
 
 
Top Targets:
7TM GPCR Srx(9)
 
 
PAS(6)
 
 
 
 
TRP 2(5)
 
 
7TM GPCR Srsx(5)
 
 
Peptidase C48(4)
 
 
BioAssay Types:
Screening(300)
 
 
 
Literature(76)
 
 
 
 
 
Confirmatory(71)
 
 
 
BioActivity Types:
Potency(54)
 
 
 
IC50(28)
 
 
 
 
 
EC50(6)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 461    Data Row: 461   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103556080]
IC50 1.491Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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2
[SID103556080]
IC50 1.491Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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3
[SID103556080]
IC50 1.491Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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4
[SID103556080]
IC50 1.679Inhibition of human CYP1B1 by EROD assay [AID502475, Type: Literature]Cytochrome P450 1B1 [gi:48429256]
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5
[SID103556080]
ED50 2.87Inhibition of chymotrypsin-like activity of purified human 20S proteasome in HL60 cells using N-succinyl-Leu-Leu-Val-Tyr-AMC as substrate pre-incubated for 10 mins by fluorimetric assay [AID623567, Type: Literature]
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6
[SID103556080]
IC50 7.906Inhibition of human CYP1A1 by EROD assay [AID502474, Type: Literature]Cytochrome P450 1A1 [gi:117139]
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7
[SID103556080]
 Effect on AhR-mediated CYP1A1 activation in mouse Hepa1c1c12 cells at 20 uM after 18 hrs by Western blot analysis [AID431868, Type: Literature]Aryl hydrocarbon receptor [gi:29337198]
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8
[SID103556080]
 Effect on AhR-mediated NAPDH quinine reductase activation in mouse Hepa1c1c12 cells at 20 uM after 18 hrs by Western blot analysis [AID431869, Type: Literature]Aryl hydrocarbon receptor [gi:29337198]
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9
[SID103556080]
 Induction of nuclear translocation of AhR from cytosol in mouse Hepa1 cells at 20 uM after 60 mins using DAPI staining by microscopic analysis [AID431870, Type: Literature]Aryl hydrocarbon receptor [gi:29337198]
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10
[SID103556080]
 Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay [AID469802, Type: Literature]
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11
[SID103556080]
 Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay [AID469799, Type: Literature]
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12
[SID103556080]
IC50 10Cytotoxicity against human HeLa cells by MTT assay [AID423636, Type: Literature]
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13
[SID103556080]
ED50 20Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay [AID623565, Type: Literature]
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14
[SID103556080]
ED50 20Induction of apoptosis in human HT-29 cells assessed reduction of mitochondrial membrane potential after 2 hrs by using JC1 staining by fluorescence cell-based assay [AID623566, Type: Literature]
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15
[SID103556080]
EC50 68Antiproliferative activity against mouse B16-BL6 cells after 72 hrs by MTT assay [AID334275, Type: Literature]
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16
[SID103556080]
IC50 71Cytotoxicity against mouse Colon 26-L5 cells after 72 hrs by MTT assay [AID470665, Type: Literature]
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17
[SID103556080]
IC50 72.8Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay [AID470662, Type: Literature]
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18
[SID103556080]
EC50 75.6Antiproliferative activity against mouse 26-L5 cells after 72 hrs by MTT assay [AID334279, Type: Literature]
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19
[SID103556080]
EC50 92.4Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay [AID334276, Type: Literature]
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20
[SID103556080]
IC50 95.53Cytotoxicity against human NCI-H187 cells after 5 days by Resazurin Microplate Assay [AID480467, Type: Literature]
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21
[SID103556080]
IC50 99.16Cytotoxicity against human KB cells after 3 days by Resazurin Microplate Assay [AID480465, Type: Literature]
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22
[SID103556080]
IC50 100Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay [AID470666, Type: Literature]
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23
[SID103556080]
IC50 100Cytotoxicity against human A549 cells after 72 hrs by MTT assay [AID470663, Type: Literature]
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24
[SID103556080]
IC50 100Cytotoxicity against human HeLa cells after 72 hrs by MTT assay [AID470664, Type: Literature]
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25
[SID103556080]
IC50 107Inhibition of PIM1 kinase [AID311148, Type: Literature]
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26
[SID103556080]
EC50 108Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay [AID334278, Type: Literature]
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27
[SID103556080]
EC50 229Antiproliferative activity against human A549 cells after 72 hrs by MTT assay [AID334277, Type: Literature]
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28
[SID103556080]
 Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleavage at 120 ppm [AID265719, Type: Literature]
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29
[SID103556080]
 Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleavage at 240 ppm [AID265721, Type: Literature]
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30
[SID103556080]
 Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleavage at 400 ppm [AID265722, Type: Literature]
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31
[SID103556080]
 Cytotoxicity against human PANC1 cells assessed as cell viability [AID311568, Type: Literature]
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32
[SID103556080]
 Antifungal activity against Cladosporium cladosporioides assessed as minimum concentration required to inhibit growth after 72 hrs by TLC [AID333446, Type: Literature]
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33
[SID103556080]
 Antifungal activity against Cladosporium sphaerospermum assessed as minimum concentration required to inhibit growth after 72 hrs by TLC [AID333447, Type: Literature]
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34
[SID103556080]
 Chemopreventive activity in Syrian hamster embryo cells assessed as inhibition of metabolism of [3H]benzo(a)pyrene to water-soluble metabolites after 24 hrs at 20 ug/ml relative to control [AID334444, Type: other]
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35
[SID103556080]
 Chemopreventive activity in Syrian hamster embryo cells assessed as inhibition of metabolism of [3H]benzo(a)pyrene to water-soluble metabolites after 24 hrs at 10 ug/ml relative to control [AID334445, Type: other]
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36
[SID103556080]
 Chemopreventive activity in Syrian hamster embryo cells assessed as inhibition of metabolism of [3H]benzo(a)pyrene to water-soluble metabolites after 24 hrs at 5 ug/ml relative to control [AID334446, Type: other]
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37
[SID103556080]
 Inhibition of bovine thymocytes protein tyrosine kinase assessed as angiotensin 1 phosphorylation [AID336952, Type: other]
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38
[SID103556080]
 Increase in EGR1 mRNA expression in human HEK293 cells at 20 ug/mL after 6 to 12 hrs by dual-glo luciferase assay relative to control [AID353303, Type: Literature]
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39
[SID103556080]
 Inhibition of p40 tyrosine kinase [AID358173, Type: other]
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40
[SID103556080]
 Cytotoxicity against african green monkey Vero cells upto 50 uM by neutral red assay [AID426207, Type: Literature]
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41
[SID103556080]
 Cytotoxicity against pig LLC-PK11 cells upto 50 uM by neutral red assay [AID426208, Type: Literature]
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42
[SID103556080]
 Cytotoxicity against human SW1353 cells by neutral red assay [AID426210, Type: Literature]
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43
[SID103556080]
 Induction of DR5 receptor promotor activity in human DLD1 cells co-transfected with Sac1 at 39 uM after 24 hrs by luciferase assay [AID449984, Type: Literature]
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44
[SID103556080]
 Induction of DR5 receptor promotor activity in human DLD1 cells co-transfected with Sac1 at 43.9 uM after 24 hrs by luciferase assay [AID449985, Type: Literature]
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45
[SID103556080]
 Antiallergic activity in Ca(2+)-stimulated differentiated human HeLa cells assessed as inhibition of cys-leukotriene release after 6 days by ELISA [AID456268, Type: Literature]
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46
[SID103556080]
 Antimicrobial activity against Enterococcus faecalis after 20 hrs by broth microdilution method [AID423362, Type: Literature]
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47
[SID103556080]
 Antimicrobial activity against vancomycin-resistant Enterococcus faecalis after 20 hrs by broth microdilution method [AID423363, Type: Literature]
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48
[SID103556080]
 Binding affinity to Enterococcus faecalis KAS3 by fluorescence quenching analysis [AID423365, Type: Literature]
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49
[SID103556080]
 Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by luciferase reporter gene assay [AID469803, Type: Literature]
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50
[SID103556080]
 Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol by luciferase reporter gene assay [AID469804, Type: Literature]
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