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diisobutyl phthalate (CID 6782) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(9)
 
 
Inactive(1009)
 
 
Inconclusive(68)
 
 
Unspecified(4)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
NR LBD PPAR(21)
 
 
 
NR LBD ER(16)
 
 
 
 
NR LBD AR(16)
 
 
 
7TM GPCR Srsx(15)
 
 
BioAssay Types:
Confirmatory(456)
 
 
 
 
 
Screening(395)
 
 
 
 
Summary(48)
 
 
 
 
Literature(6)
 
 
 
BioActivity Types:
Potency(406)
 
 
 
 
 
IC50(37)
 
 
EC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 766    Data Row: 1090   Total Pages: 22   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144209627]
Potency-Replicate_1 0.0138qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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2
[SID144209627]
Ratio Potency (uM) 0.0309183qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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3
[SID144209627]
Potency-Replicate_1 21.6899qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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4
[SID144209627]
Potency-Replicate_1 27.306qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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5
[SID144210929]
Potency-Replicate_1 27.306qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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6
[SID144209627]
Potency-Replicate_1 30.6379qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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7
[SID144210929]
Potency-Replicate_1 68.5896qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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8
[SID17389499]
Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines [AID588813_49, Type: other]
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9
[SID56436642]
uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) [AID602440, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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10
[SID56436642]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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11
[SID17389499]
Cell Viability Profiling of Human Lymphoblast Cell Lines [AID588812, Type: other]
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12
[SID17389499]
Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines [AID588813, Type: other]
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13
[SID17389499]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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14
[SID14719324]
Potency 10.4179Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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15
[SID14719324]
Potency 13.1154Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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16
[SID144210929]
Potency-Replicate_1 54.941qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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17
[SID56436642]
Potency 56.2341qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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18
[SID56436642]
Potency 79.4328HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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19
[SID14719324]
Potency 89.1251qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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20
[SID56436642]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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21
[SID56436642]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R1A (PKA-R1A) complex [AID504707, Type: screening]cAMP-dependent protein kinase catalytic subunit beta isoform 1 [Mus musculus] [gi:6755076]
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22
[SID14719324]
Kallikrein 5 1536 HTS [AID873, Type: screening]kallikrein-5 preproprotein [Homo sapiens] [gi:6912644]
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23
[SID56436642]
Dyrk1 A HTS Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_SinglePoint_HTS_Activity [AID504441, Type: screening]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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24
[SID14719324]
Potency qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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25
[SID17389499]
Potency qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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26
[SID56436642]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624037, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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27
[SID56436642]
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624038, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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28
[SID56436642]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624040, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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29
[SID14719324]
High Throughput Screening for Cocaine Antagonists: Primary Screen [AID449768, Type: screening]dopamine transporter [Homo sapiens] [gi:7108463]
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30
[SID56436642]
Potency qHTS of IL-2 Activators [AID652025, Type: confirmatory]interleukin-2 precursor [Mus musculus] [gi:7110653]
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31
[SID56436642]
Potency qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase plasminogen activator surface receptor precursor [Mus musculus] [gi:7242179]
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32
[SID56436642]
Hedgehog Measured in Biochemical System Using Plate Reader - 2070-01_Inhibitor_SinglePoint_HTS_Activity [AID588832, Type: screening]hedgehog, isoform A [Drosophila melanogaster] [gi:7300964]
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33
[SID14719324]
uHTS of Mcl-1/Bid interaction inhibitors [AID1021, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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34
[SID14719324]
uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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35
[SID56436642]
uHTS identification of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay [AID624204, Type: screening]sentrin-specific protease 1 [Homo sapiens] [gi:7657550]
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36
[SID14719324]
qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase isoform 1 [Homo sapiens] [gi:7669492]
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37
[SID56436642]
Potency qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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38
[SID56436642]
Potency A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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39
[SID56436642]
Potency A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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40
[SID14719324]
Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK9 [AID488922, Type: screening]potassium channel subfamily K member 9 [Homo sapiens] [gi:7706135]
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41
[SID56436642]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Phosphatase Methylesterase 1 (PME-1). [AID2130, Type: screening]protein phosphatase methylesterase 1 isoform a [Homo sapiens] [gi:7706645]
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42
[SID56436642]
Potency qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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43
[SID56436642]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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44
[SID56436642]
Identification of VIF Inhibitors Measured in Cell-Based System Using Imaging - 2108-01_Inhibitor_SinglePoint_HTS_Activity [AID602346, Type: screening]Vif [Human immunodeficiency virus 1] [gi:9629361]
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45
[SID56436642]
TRFRET-based biochemical primary high throughput screening assay to identify small molecules that bind to the HIV-1-gp120 binding antibody, PG9 [AID624416, Type: screening]Envelope surface glycoprotein gp160, precursor [Human immunodeficiency virus 1] [gi:9629363]
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46
[SID56436642]
Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for MLPCN Compound Set [AID602162, Type: screening]ATP-binding cassette sub-family B member 6, mitochondrial [Homo sapiens] [gi:9955963]
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47
[SID56436642]
Fluorescence Polarization with Cer CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-01_Inhibitor_SinglePoint_HTS_Activity [AID504414, Type: screening]Golgi-associated PDZ and coiled-coil motif-containing protein isoform a [Homo sapiens] [gi:9966877]
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48
[SID56436642]
qHTS for Agonists of the Human Mucolipin Transient Receptor Potential 1 (TRPML1) [AID624414, Type: screening]mucolipin-1 [Homo sapiens] [gi:10092597]
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49
[SID56436642]
qHTS for Inhibitors of the Human Mucolipin Transient Receptor Potential 1 (TRPML1) [AID624415, Type: screening]mucolipin-1 [Homo sapiens] [gi:10092597]
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50
[SID17389499]
IkB Signaling [AID445, Type: confirmatory]NF-kappa-B inhibitor alpha [Homo sapiens] [gi:10092619]
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