Phenylthiourea (CID 676454) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(7)
 
 
Inactive(338)
 
 
Inconclusive(16)
 
 
Unspecified(11)
 
 
Top Targets:
NR LBD PPAR(15)
 
 
 
NR LBD TR(12)
 
 
P53(7)
 
 
 
NR LBD VDR(6)
 
 
NR LBD RXR li..(6)
 
 
BioAssay Types:
Confirmatory(308)
 
 
 
Literature(19)
 
 
 
 
BioActivity Types:
Potency(236)
 
 
 
IC50(6)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 178    Data Row: 372   Total Pages: 8   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103565465]
IC50 1.5Inhibition of mushroom tyrosinase activity using L-tyrosine as substrate by spectrometric analysis [AID626570, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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2
[SID103565465]
IC50 1.8Inhibition of mushroom tyrosinase [AID331282, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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3
[SID103565465]
IC50 1.8Inhibition of tyrosinase in alpha-MSH-induced mouse B16 cells [AID494974, Type: Literature]
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4
[SID103565465]
IC50 1.8Inhibition of tyrosinase [AID457969, Type: Literature]
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5
[SID103565465]
IC50 5.4Inhibition of melanogenesis in mouse B16 cells [AID480030, Type: Literature]
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6
[SID46391587]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Catechol Oxidase From Ipomoea Batatas (Sweet Potatoes)- Inhibitor Complex With Phenylthiour [gi:6137621]
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7
[SID103565465]
 Inhibition of tyrosinase in human HEMn-MP assessed as reduction of melanin level at 100 uM after 2 days by spectrophotometric analysis [AID492070, Type: Literature]Tyrosinase [gi:401235]
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8
[SID103565465]
IC50 100Inhibition of Haemophilus influenzae recombinant DapE [AID467024, Type: Literature]Succinyl-diaminopimelate desuccinylase [gi:1169224]
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9
[SID103565465]
 Inhibition of melanin production in mouse B16 cells at 100 uM [AID331283, Type: Literature]
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10
[SID103565465]
 Inhibition of mushroom tyrosinase activity using L-tyrosine as substrate at 10 uM by spectrometric analysis [AID626569, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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11
[SID103565465]
 Antimelanogenic activity in mouse B16 cells assessed as inhibition of alpha-MSH-induced melanogenesis at 100 uM [AID494973, Type: Literature]
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12
[SID103565465]
 Inhibition of alpha-MSH-induced melanin production in mouse B16 cells at 100 uM after 72 hrs [AID457971, Type: Literature]
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13
[SID103565465]
 Inhibition of melanogenesis in mouse B16 cells at 10 uM [AID480029, Type: Literature]
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14
[SID103565465]
 Depigmentation effect in mouse Melan-a cells assessed as difference between cell viability and melanin content at 30 uM [AID497307, Type: Literature]
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15
[SID103565465]
 Cytotoxicity against mouse Melan-a cells assessed as cell viability at 30 uM [AID497308, Type: Literature]
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16
[SID17388780]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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17
[SID17389761]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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18
[SID26752856]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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19
[SID17388780]
Potency 2.6603qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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20
[SID17388780]
Potency 2.6603qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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21
[SID17388780]
Potency 2.6603qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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22
[SID17388780]
Potency 2.6603qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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23
[SID17388780]
Potency 2.6603qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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24
[SID17389761]
Potency 5.0119qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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25
[SID17389761]
Potency 5.0119qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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26
[SID17389761]
Potency 5.0119qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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27
[SID17389761]
Potency 5.9557qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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28
[SID17389761]
Potency 5.9557qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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29
[SID17389761]
Potency 5.9557qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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30
[SID17389761]
Potency 5.9557qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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31
[SID17389761]
Potency 5.9557qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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32
[SID17388780]
Potency 39.8107qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
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33
[SID17388780]
Potency 39.8107qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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34
[SID17388780]
Potency 39.8107qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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35
[SID17389761]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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36
[SID17389761]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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37
[SID17389761]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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38
[SID17389761]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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39
[SID17388780]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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40
[SID17388780]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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41
[SID17388780]
Potency qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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42
[SID17388780]
Potency qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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43
[SID17389761]
Potency qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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44
[SID17389761]
Potency qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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45
[SID17389761]
Potency qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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46
[SID17388780]
Potency qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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47
[SID26752856]
Potency qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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48
[SID26752856]
Potency qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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49
[SID26752856]
Potency qHTS assay for small molecule antagonists of androgen receptor signaling [AID588516, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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50
[SID26752856]
Potency qHTS assay for small molecule antagonists of androgen receptor signaling [AID588516, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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