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Phenylthiourea (CID 676454) - Compound BioActivity Data
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BioActivity Outcomes:
Active(8)
 
 
Inactive(517)
 
 
Inconclusive(32)
 
 
Unspecified(11)
 
 
Top Targets:
NR LBD PPAR(31)
 
 
 
NR LBD AR(20)
 
 
 
NR LBD ER(20)
 
 
 
NR LBD TR(18)
 
 
 
 
NR LBD GR(14)
 
 
 
BioAssay Types:
Confirmatory(455)
 
 
 
Summary(48)
 
 
 
Literature(19)
 
 
 
 
BioActivity Types:
Potency(417)
 
 
 
 
IC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 271    Data Row: 568   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103565465]
IC50 1.5Inhibition of mushroom tyrosinase activity using L-tyrosine as substrate by spectrometric analysis [AID626570, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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2
[SID103565465]
IC50 1.8Inhibition of mushroom tyrosinase [AID331282, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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3
[SID103565465]
IC50 1.8Inhibition of tyrosinase in alpha-MSH-induced mouse B16 cells [AID494974, Type: Literature]
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4
[SID103565465]
IC50 1.8Inhibition of tyrosinase [AID457969, Type: Literature]
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5
[SID103565465]
IC50 5.4Inhibition of melanogenesis in mouse B16 cells [AID480030, Type: Literature]
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6
[SID144208880]
TR Potency (uM) 47.4909qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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7
[SID103565465]
Inhibition of tyrosinase in human HEMn-MP assessed as reduction of melanin level at 100 uM after 2 days by spectrophotometric analysis [AID492070, Type: Literature]Tyrosinase [gi:401235]
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8
[SID46391587]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Catechol Oxidase From Ipomoea Batatas (Sweet Potatoes)- Inhibitor Complex With Phenylthiourea (Ptu) [gi:6137621]
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9
[SID103565465]
IC50 100Inhibition of Haemophilus influenzae recombinant DapE [AID467024, Type: Literature]Succinyl-diaminopimelate desuccinylase [gi:1169224]
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10
[SID103565465]
Inhibition of mushroom tyrosinase activity using L-tyrosine as substrate at 10 uM by spectrometric analysis [AID626569, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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11
[SID26752856]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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12
[SID17389761]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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13
[SID17388780]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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14
[SID103565465]
Inhibition of alpha-MSH-induced melanin production in mouse B16 cells at 100 uM after 72 hrs [AID457971, Type: Literature]
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15
[SID103565465]
Inhibition of melanogenesis in mouse B16 cells at 10 uM [AID480029, Type: Literature]
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16
[SID103565465]
Antimelanogenic activity in mouse B16 cells assessed as inhibition of alpha-MSH-induced melanogenesis at 100 uM [AID494973, Type: Literature]
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17
[SID103565465]
Depigmentation effect in mouse Melan-a cells assessed as difference between cell viability and melanin content at 30 uM [AID497307, Type: Literature]
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18
[SID103565465]
Cytotoxicity against mouse Melan-a cells assessed as cell viability at 30 uM [AID497308, Type: Literature]
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19
[SID103565465]
Inhibition of melanin production in mouse B16 cells at 100 uM [AID331283, Type: Literature]
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20
[SID17388780]
Potency 2.6603qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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21
[SID17389761]
Potency 5.0119qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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22
[SID17389761]
Potency 5.9557qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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23
[SID17388780]
Potency 39.8107qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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24
[SID17388780]
Potency 39.8107qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
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25
[SID144213315]
Potency-Replicate_1 68.5896qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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26
[SID144213315]
Potency-Replicate_1 qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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27
[SID144213315]
Ratio Potency (uM) qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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28
[SID144213315]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HepG2 cells [AID720674, Type: confirmatory]
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29
[SID144213315]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cells [AID720675, Type: confirmatory]
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30
[SID144208880]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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31
[SID144208880]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743218, Type: confirmatory]
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32
[SID144208880]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743221, Type: confirmatory]
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33
[SID144208880]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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34
[SID144208880]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
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35
[SID144213315]
Potency-Replicate_1 qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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36
[SID144208880]
Potency-Replicate_1 qHTS assay to identify aromatase inhibitors - cell viability counter screen [AID743084, Type: confirmatory]
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37
[SID144208880]
Potency-Replicate_1 qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway - cell viability counter screen [AID743086, Type: confirmatory]
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38
[SID144213315]
Potency-Replicate_1 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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39
[SID144213315]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cells [AID720678, Type: confirmatory]
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40
[SID144213315]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cells [AID720679, Type: confirmatory]
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41
[SID144213315]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells [AID720680, Type: confirmatory]
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42
[SID144213315]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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43
[SID144213315]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell free culture [AID720682, Type: confirmatory]
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44
[SID144213315]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cell free culture [AID720683, Type: confirmatory]
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45
[SID144213315]
Potency-Replicate_1 qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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46
[SID144208880]
Potency-Replicate_1 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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47
[SID144208880]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cells [AID720679, Type: confirmatory]
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48
[SID144208880]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells [AID720680, Type: confirmatory]
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49
[SID144208880]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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50
[SID144208880]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell free culture [AID720682, Type: confirmatory]
View