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9,10-phenanthrenequinone (CID 6763) - Compound BioActivity Data
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BioActivity Outcomes:
Active(272)
 
 
Inactive(657)
 
 
Inconclusive(67)
 
 
Unspecified(13)
 
 
Top Targets:
7tm 4(47)
 
 
 
Esterase lipa..(14)
 
 
 
alkPPc(12)
 
 
Bcl-2 like(11)
 
 
Telomerase RB..(9)
 
 
 
 
BioAssay Types:
Screening(632)
 
 
 
 
 
Confirmatory(286)
 
 
 
 
 
Literature(53)
 
 
 
 
 
BioActivity Types:
Potency(160)
 
 
 
 
 
IC50(82)
 
 
 
 
 
EC50(30)
 
 
 
 
AC50(10)
 
 
 
Ki(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 893    Data Row: 1009   Total Pages: 51   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103235164]
Ki 0.0025Inhibition of human carboxylesterase 1 [AID302991, Type: Literature]Liver carboxylesterase 1 [gi:119576]
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2
[SID103235164]
Ki 0.0025Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assay [AID731515, Type: Literature]Liver carboxylesterase 1 [gi:119576]
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3
[SID103235164]
Ki 0.052Inhibition of human iCE using o-NPA as substrate by spectrophotometric assay [AID731514, Type: Literature]Cocaine esterase [gi:46576349]
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4
[SID103235164]
Ki 0.052Inhibition of human intestinal carboxylesterase [AID302990, Type: Literature]
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5
[SID16952991]
Potency 0.1409qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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6
[SID103235164]
Ki 0.19Inhibition of human butyrylcholinesterase [AID302993, Type: Literature]Cholinesterase [gi:116353]
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7
[SID103235164]
IC50 0.3In vitro inhibition of human T-cell proliferation [AID210283, Type: Literature]
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8
[SID103235164]
IC50 0.5Inhibition of pre-assembled human recombinant telomerase activity in rabbit reticulocytes after 90 mins by gel electrophoresis method based direct primer extension assay [AID694270, Type: Literature]Telomerase reverse transcriptase [gi:6226780]
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9
[SID16952991]
Potency 0.5174qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID50085435]
IC50_Mean 0.549Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay [AID588524, Type: confirmatory]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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11
[SID16952991]
Potency 0.5805qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID103235164]
IC50 0.7In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate [AID42805, Type: Literature]
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13
[SID16952991]
Potency 0.7079qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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14
[SID16952991]
DR EC50 uM 0.71NIH Compound Library Profiling: Compound and DTT Dependent Redox Cycling H2O2 Generation 10-point Concentration Response Confirmation Assay. [AID1234, Type: confirmatory]
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15
[SID16952991]
Potency 0.8406Confirmatory Assay for Inhibitors of Human Galactokinase (GALK): Phenol-HRP redox assay counterscreen [AID2035, Type: confirmatory]
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16
[SID16952991]
Potency 0.8913qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Rabbit FBPA Selectivity [AID2794, Type: confirmatory]fructose-bisphosphate aldolase A [Oryctolagus cuniculus] [gi:126722869]
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17
[SID50085435]
IC50_Mean 0.903Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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18
[SID50085435]
IC50_Mean 0.903Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-9 isoform alpha precursor [Homo sapiens] [gi:14790124]
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19
[SID16952991]
Potency 0.92qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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20
[SID16952991]
Potency 1Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein, partial [Homo sapiens] [gi:118600387]
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