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9,10-phenanthrenequinone (CID 6763) - Compound BioActivity Data
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BioActivity Outcomes:
Active(266)
 
 
Inactive(644)
 
 
Inconclusive(67)
 
 
Unspecified(11)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
 
7TM GPCR Srsx(20)
 
 
 
alkPPc(12)
 
 
Bcl-2 like(11)
 
 
Telomerase RB..(9)
 
 
 
 
BioAssay Types:
Screening(631)
 
 
 
 
 
Confirmatory(286)
 
 
 
 
 
Literature(33)
 
 
 
 
 
BioActivity Types:
Potency(160)
 
 
 
 
 
IC50(82)
 
 
 
 
 
EC50(30)
 
 
 
 
AC50(10)
 
 
 
Ki(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 884    Data Row: 988   Total Pages: 20   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103235164]
Ki 0.0025Inhibition of human carboxylesterase 1 [AID302991, Type: Literature]Liver carboxylesterase 1 [gi:119576]
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2
[SID103235164]
Ki 0.0025Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assay [AID731515, Type: Literature]Liver carboxylesterase 1 [gi:119576]
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3
[SID103235164]
Ki 0.052Inhibition of human intestinal carboxylesterase [AID302990, Type: Literature]
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4
[SID103235164]
Ki 0.052Inhibition of human iCE using o-NPA as substrate by spectrophotometric assay [AID731514, Type: Literature]Cocaine esterase [gi:46576349]
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5
[SID16952991]
Potency 0.1409qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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6
[SID103235164]
Ki 0.19Inhibition of human butyrylcholinesterase [AID302993, Type: Literature]Cholinesterase [gi:116353]
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7
[SID103235164]
IC50 0.3In vitro inhibition of human T-cell proliferation [AID210283, Type: Literature]
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8
[SID103235164]
IC50 0.5Inhibition of pre-assembled human recombinant telomerase activity in rabbit reticulocytes after 90 mins by gel electrophoresis method based direct primer extension assay [AID694270, Type: Literature]Telomerase reverse transcriptase [gi:6226780]
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9
[SID16952991]
Potency 0.5174qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID50085435]
IC50_Mean 0.549Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay [AID588524, Type: confirmatory]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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11
[SID16952991]
Potency 0.5805qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID103235164]
IC50 0.7In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate [AID42805, Type: Literature]
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13
[SID16952991]
Potency 0.7079qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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14
[SID16952991]
DR EC50 uM 0.71NIH Compound Library Profiling: Compound and DTT Dependent Redox Cycling H2O2 Generation 10-point Concentration Response Confirmation Assay. [AID1234, Type: confirmatory]
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15
[SID16952991]
Potency 0.8406Confirmatory Assay for Inhibitors of Human Galactokinase (GALK): Phenol-HRP redox assay counterscreen [AID2035, Type: confirmatory]
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16
[SID16952991]
Potency 0.8913qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Rabbit FBPA Selectivity [AID2794, Type: confirmatory]fructose-bisphosphate aldolase A [Oryctolagus cuniculus] [gi:126722869]
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17
[SID50085435]
IC50_Mean 0.903Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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18
[SID50085435]
IC50_Mean 0.903Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-9 isoform alpha precursor [Homo sapiens] [gi:14790124]
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19
[SID16952991]
Potency 0.92qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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20
[SID16952991]
Potency 1Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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21
[SID50085435]
AC50_uM 1.006ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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22
[SID50085435]
AC50_uM 1.013Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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23
[SID16952991]
Potency 1.122qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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24
[SID16952991]
Potency 1.122qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen confirmation [AID2795, Type: confirmatory]glyceraldehyde-3-phosphate dehydrogenase isoform 1 [Homo sapiens] [gi:7669492]
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25
[SID16952991]
Potency 1.122qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Primary screen confirmation [AID2787, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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26
[SID16952991]
Potency 1.1582qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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27
[SID16952991]
IC50_Mean 1.25Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. [AID504756, Type: confirmatory]cysteine protease ATG4B isoform a [Homo sapiens] [gi:47132611]
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28
[SID50085435]
EC50 1.255Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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29
[SID16952991]
Potency 1.2589qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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30
[SID103235164]
CC50 1.3Cytotoxicity measured against human T-cells [AID210280, Type: Literature]
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31
[SID50085435]
EC50 1.334Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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32
[SID103235164]
IC50 1.4Inhibitory activity against HRV 3Cpro using HPLC assay [AID163631, Type: Literature]
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33
[SID16952991]
Potency 1.7783qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Cytotoxicity Assay [AID602204, Type: confirmatory]
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34
[SID50085435]
IC50 1.839Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3): TR-FRET-based biochemical high throughput dose response assay to identify agonists of the interaction between peroxisome proliferator-activated receptor gamma (PPARg) and nuclear receptor co-repressor 2 (NCOR2) [AID2759, Type: confirmatory]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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35
[SID50085435]
IC50 1.839Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3): TR-FRET-based biochemical high throughput dose response assay to identify agonists of the interaction between peroxisome proliferator-activated receptor gamma (PPARg) and nuclear receptor co-repressor 2 (NCOR2) [AID2759, Type: confirmatory]nuclear receptor corepressor 2 isoform 2 [Homo sapiens] [gi:116256445]
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36
[SID16952991]
Potency 1.8818Confirmation Assay for Inhibitors of Human Galactokinase (GALK) [AID2015, Type: confirmatory]galactokinase [Homo sapiens] [gi:4503895]
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37
[SID50085435]
IC50 1.907Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) [AID743297, Type: confirmatory]tyrosyl-DNA phosphodiesterase 2 [Homo sapiens] [gi:23510348]
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38
[SID50085435]
AC50_uM 1.93CEM21 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7013-03_Inhibitor_Dose_CherryPick_Activity [AID652042, Type: confirmatory]
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39
[SID50085435]
EC50 1.964Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast [AID1933, Type: confirmatory]
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40
[SID16952991]
Potency 1.9953qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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41
[SID16952991]
IC50 2.029Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4) [AID1692, Type: confirmatory]Sphingosine-1-phosphate receptor 4 [Homo sapiens] [gi:15929025]
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42
[SID50085435]
EC50 2.22A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
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43
[SID50085435]
EC50 2.303Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
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44
[SID50085435]
CC50 2.334A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Inhibit Mycobacterium Tuberculosis [AID435019, Type: confirmatory]
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45
[SID50085435]
IC50 2.4Fluorescence-based biochemical high throughput screening dose response assay to identify inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Pep-AMC substrate [AID720578, Type: confirmatory]putative polyprotein [Crimean-Congo hemorrhagic fever virus] [gi:76364066]
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46
[SID16952991]
Potency 2.5119qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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47
[SID50085435]
AC50_uM 2.66HIV-1 Cell Fusion assay for clade B Env AD8 Measured in Cell-Based System Using Plate Reader - 7013-04_Inhibitor_Dose_CherryPick_Activity [AID652062, Type: confirmatory]
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48
[SID16952991]
Potency 2.8184qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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49
[SID16952991]
Potency 2.8184qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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50
[SID16952991]
Potency 2.8184qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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