lawsone (CID 6755) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(5)
 
 
Inactive(100)
 
 
Inconclusive(13)
 
 
Unspecified(31)
 
 
Top Targets:
Peptidase C1A(6)
 
 
 
 
Menin(4)
 
 
NR LBD ROR li..(4)
 
 
Tubulin-bindi..(4)
 
 
 
NR LBD TR(4)
 
 
BioAssay Types:
Confirmatory(95)
 
 
 
 
Literature(33)
 
 
 
 
Screening(5)
 
 
BioActivity Types:
Potency(91)
 
 
 
 
IC50(7)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 113    Data Row: 149   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID50107733]
Potency 8.9125Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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2
[SID50107733]
Potency 8.9125Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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3
[SID50107733]
Potency 8.9125Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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4
[SID50107733]
Potency 8.9125Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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5
[SID50107733]
Potency 15.8489qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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6
[SID50107733]
Potency 15.8489qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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7
[SID26749851]
Potency 17.7828Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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8
[SID26749851]
Potency 17.7828Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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9
[SID26749851]
Potency 17.7828Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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10
[SID26749851]
Potency 17.7828Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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11
[SID26749851]
Potency 50.1187Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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12
[SID50107733]
Potency 79.4328qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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13
[SID103222862]
IC50 100Inhibitory activity against HIV-1 integrase [AID93531, Type: Literature]Integrase [gi:82312013]
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14
[SID103222862]
IC50 100Inhibitory activity against HIV-1 integrase [AID93543, Type: Literature]Integrase [gi:82312013]
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15
[SID103222862]
IC50 100Inhibitory activity against HIV-1 protease [AID162196, Type: Literature]Pol polyprotein [gi:75593047]
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16
[SID103222862]
IC50 100In vitro antimalarial activity against human malaria parasite, P falciparum (Vietnam Smith strain) [AID152094, Type: Literature]
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17
[SID103222862]
IC50 150Inhibitory activity against HRV 3Cpro using HPLC assay [AID163631, Type: Literature]
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18
[SID103544392]
IC50 675Inhibition of purified human recombinant IDO [AID326467, Type: Literature]Indoleamine 2,3-dioxygenase 1 [gi:123948]
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19
[SID103544392]
IC50 2500Trypanocidal activity against bloodstream form of Trypanosoma cruzi Y isolated from albino mouse blood after 24 hrs by neubauer chamber analysis [AID660266, Type: Literature]
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20
[SID103544392]
 Inhibition of papain at 1.3 mM after 20 mins [AID308236, Type: Literature]Papain [gi:129614]
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21
[SID103544392]
 Inhibition of mushroom tyrosinase at 1 mM after 10 mins [AID566699, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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22
[SID103544392]
 Inhibition of human recombinant 5-lipoxygenase at 1 mM after 10 mins by fluorescence assay [AID566700, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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23
[SID103544392]
 Antiinflammatory activity in CD1 mouse assessed as inhibition of croton oil-induced ear oedema at 0.3 umol/cm^2 after 6 hrs [AID309363, Type: Literature]
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24
[SID103544392]
 Antimicrobial activity against Porphyromonas gingivalis ATCC 33277 assessed as bacterial growth at 250 ug/ml after 4 hrs by XTT assay relative to control [AID349291, Type: Literature]
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25
[SID103544392]
 Antimicrobial activity against Porphyromonas gingivalis ATCC 33277 assessed as bacterial growth at 125 ug/ml after 4 hrs by XTT assay relative to control [AID349292, Type: Literature]
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26
[SID103544392]
 Antimicrobial activity against Porphyromonas gingivalis ATCC 33277 assessed as bacterial growth at 62.5 ug/ml after 4 hrs by XTT assay relative to control [AID349293, Type: Literature]
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27
[SID103544392]
 Antimicrobial activity against Porphyromonas gingivalis ATCC 33277 assessed as bacterial growth at 31.2 ug/ml after 4 hrs by XTT assay relative to control [AID349294, Type: Literature]
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28
[SID103544392]
 Antimicrobial activity against Streptococcus mutans ATCC 25175 assessed as inhibition of biofilm formation at 31.3 ug/ml after 48 hrs [AID349300, Type: Literature]
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29
[SID103544392]
 Antimicrobial activity against Porphyromonas gingivalis ATCC 33277 assessed as bacterial growth at 15.6 ug/ml after 4 hrs by XTT assay relative to control [AID349295, Type: Literature]
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30
[SID103544392]
 Antimicrobial activity against Porphyromonas gingivalis ATCC 33277 assessed as bacterial growth at 7.8 ug/ml after 4 hrs by XTT assay relative to control [AID349296, Type: Literature]
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31
[SID103544392]
 Antimicrobial activity against Porphyromonas gingivalis ATCC 33277 assessed as bacterial growth at 3.9 ug/ml after 4 hrs by XTT assay relative to control [AID349297, Type: Literature]
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32
[SID103222862]
 Partition coefficient (logP) [AID23482, Type: Literature]
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33
[SID103222862]
 Effective dose that would give a 25% increase in the survival time against the ascitic sarcoma 180 in mice [AID39233, Type: Literature]
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34
[SID103222862]
 Solubility in water was determined [AID21140, Type: Literature]
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35
[SID103222862]
 Tested for its ability to eliminate the infective trypomastigote form of Trypanosoma cruzi, Y strain present in blood of infected mice at the dose of 0.29 mM [AID115276, Type: other]
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36
[SID103222862]
 Tested for acute toxicity which is the single dose given intraperitoneally that will kill one-half of the mice within 5 days [AID117228, Type: Literature]
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37
[SID103222862]
 Maximum survival by an optimum dose at 25 mg/kg in treated to that of untreated mice [AID117488, Type: Literature]
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38
[SID103544392]
 Inhibition of human recombinant MMP1 at 1 mM after 30 mins [AID566702, Type: Literature]Interstitial collagenase [gi:116852]
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39
[SID103544392]
 Inhibition of human recombinant MMP2 at 1 mM after 30 mins [AID566703, Type: Literature]72 kDa type IV collagenase [gi:116856]
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40
[SID103544392]
 Inhibition of human recombinant MMP2 at 1 mM after 30 mins [AID566703, Type: Literature]72 kDa type IV collagenase [gi:116856]
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41
[SID103544392]
 Inhibition of human recombinant MMP2 at 1 mM after 30 mins [AID566703, Type: Literature]72 kDa type IV collagenase [gi:116856]
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42
[SID103544392]
 Inhibition of human recombinant MMP3 at 1 mM after 30 mins [AID566704, Type: Literature]Stromelysin-1 [gi:116857]
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43
[SID103544392]
 Inhibition of human recombinant MMP3 at 1 mM after 30 mins [AID566704, Type: Literature]Stromelysin-1 [gi:116857]
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44
[SID103544392]
 Inhibition of human recombinant MMP8 at 1 mM after 30 mins [AID566705, Type: Literature]Neutrophil collagenase [gi:116862]
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45
[SID103544392]
 Inhibition of human recombinant MMP8 at 1 mM after 30 mins [AID566705, Type: Literature]Neutrophil collagenase [gi:116862]
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46
[SID103544392]
 Inhibition of human recombinant MMP9 at 1 mM after 30 mins [AID566706, Type: Literature]Matrix metalloproteinase-9 [gi:269849668]
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47
[SID103544392]
 Inhibition of recombinant anthrax lethal factor at 1 mM after 30 mins by fluorescence assay [AID566701, Type: Literature]Lethal factor [gi:50402185]
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48
[SID26749851]
Potency 0.0316qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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49
[SID26749851]
Potency 0.0316qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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50
[SID26749851]
Potency 0.0316qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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