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7-Anilino-1-naphthol-3-sulfonic Acid (CID 67062) - Compound BioActivity Data
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BioActivity Outcomes:
Active(74)
 
 
Inactive(277)
 
 
Inconclusive(10)
 
 
Unspecified(4)
 
 
Top Targets:
7tm 4(23)
 
 
CASc(7)
 
 
 
PTPc(6)
 
 
 
RasGEF(4)
 
 
 
Troponin(4)
 
 
BioAssay Types:
Screening(229)
 
 
 
Confirmatory(114)
 
 
 
 
 
Literature(15)
 
 
 
 
BioActivity Types:
Potency(83)
 
 
 
 
 
IC50(22)
 
 
 
 
AC50(10)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 325    Data Row: 365   Total Pages: 19   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID89853614]
IC50_Mean 0.335Dose Response selectivity of inhibitors of Striatal-Enriched Phosphatase (STEP) in a SHP2 (PTPN11) Inhibition Assay [AID602367, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 11 isoform 1 [Homo sapiens] [gi:33356177]
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2
[SID89853614]
AC50_uM 0.403VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity [AID720632, Type: confirmatory]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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3
[SID89853614]
IC50_Mean 0.485Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay [AID602374, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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4
[SID89853614]
AC50_uM 1.8Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_Dose_CherryPick_Activity [AID1053173, Type: confirmatory]histone-lysine N-methyltransferase NSD2 isoform 1 [Homo sapiens] [gi:109633019]
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5
[SID89853614]
Potency 1.9953qHTS for Inhibitors of PI5P4K: Confirmation in Primary Assay [AID743286, Type: confirmatory]Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [gi:18266879]
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6
[SID89853614]
IC50 2.729TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID1053172, Type: confirmatory]integrase, partial [Human immunodeficiency virus 1] [gi:2853980]
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7
[SID89853614]
IC50 2.729TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID1053172, Type: confirmatory]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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8
[SID89853614]
Potency 2.8184qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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9
[SID89853614]
Potency 3.1623qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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10
[SID89853614]
Potency 3.3587qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds [AID720501, Type: Literature]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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11
[SID89853614]
IC50 3.59Counterscreen for inhibitors of LEDGF/p75-dependent integration: TR-FRET-based biochemical high throughput dose response counterscreen assay to identify activators of HIV-1 Integrase multimerization [AID1053171, Type: confirmatory]integrase, partial [Human immunodeficiency virus 1] [gi:2853980]
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12
[SID89853614]
IC50 3.59Counterscreen for inhibitors of LEDGF/p75-dependent integration: TR-FRET-based biochemical high throughput dose response counterscreen assay to identify activators of HIV-1 Integrase multimerization [AID1053171, Type: confirmatory]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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13
[SID89853614]
IC50_Mean 4.47Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence resonance energy transfer assay [AID624383, Type: confirmatory]SUMO-1 [Homo sapiens] [gi:1762973]
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14
[SID89853614]
IC50 5.09Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the Lymphoid Phosphatase (PTPN22) Inhibition Assay [AID624241, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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15
[SID89853614]
AbsAC35_uM 6.4ALPHAscreen artifact counterscreen Measured in Biochemical System Using Plate Reader - 7053-03_Inhibitor_Dose_CherryPick_Activity [AID1053174, Type: confirmatory]
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16
[SID89853614]
IC50_Mean 6.49Dose response confirmation of uHTS small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID602372, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 5 isoform a [Homo sapiens] [gi:90652859]
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17
[SID89853614]
Potency 9.1905qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen [AID686980, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:115503961]
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18
[SID89853614]
Potency 10.691qHTS Assay to Find Inhibitors of Pin1: Hit Validation [AID624308, Type: confirmatory]peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Homo sapiens] [gi:5453898]
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19
[SID89853614]
Potency 11.2202qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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20
[SID89853614]
Potency 11.9955qHTS Assay to Find Inhibitors of Pin1: Hit Validation using Tamra Binding [AID624312, Type: confirmatory]peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Homo sapiens] [gi:5453898]
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