Bookmark and Share
Dihydroxyacetone (CID 670) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(21)
 
 
Inactive(6)
 
 
Unspecified(36)
 
 
BioAssay Types:
Literature(63)
 
 
 
 
BioActivity Types:
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 63    Data Row: 63   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104246132]
Trypanocidal activity against Trypanosoma brucei bloodstream form assessed as cell death at 1 mM after 40 mins by spectrophotometry [AID372259, Type: Literature]
View
2
[SID104246132]
Trypanocidal activity against Trypanosoma brucei bloodstream form at < 1 mM [AID372260, Type: Literature]
View
3
[SID104246132]
Trypanocidal activity against Trypanosoma brucei bloodstream form at > 1 mM [AID372261, Type: Literature]
View
4
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as presence of more than one flagellum at 5 mM after 20 hrs by scanning electron microscopy [AID372271, Type: Literature]
View
5
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as increase in mitochondrion size at 3 mM after 24 hrs by transmission electron microscopy [AID372281, Type: Literature]
View
6
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as dilation of mitochondrion membrane at 3 mM after 24 hrs by transmission electron microscopy [AID372282, Type: Literature]
View
7
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as disorder of mitochondrion structure at 3 mM after 24 hrs by transmission electron microscopy [AID372283, Type: Literature]
View
8
[SID104246132]
Effect on cell cycle of Trypanosoma brucei bloodstream form assessed as increase in cells with two nuclei and two kinetoplasts at 1 to 3 mM using DAPI staining by phase-contrast microscopy [AID372285, Type: Literature]
View
9
[SID104246132]
Effect on cell cycle of Trypanosoma brucei bloodstream form assessed as increase in cells with two nuclei and one kinetoplast at 1 to 3 mM using DAPI staining by phase-contrast microscopy [AID372286, Type: Literature]
View
10
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as dilation of mitochondrial membrane at 3 mM after 24 hrs by transmission electron microscopy [AID372299, Type: Literature]
View
11
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as presence of glycosomes at 3 mM after 24 hrs by transmission electron microscopy [AID372300, Type: Literature]
View
12
[SID104246132]
Trypanocidal activity against Trypanosoma brucei bloodstream form assessed as induction of autophagy at 3 mM after 24 hrs by transmission electron microscopy [AID372302, Type: Literature]
View
13
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as presence of more than one flagellum at 3 mM after 24 hrs by transmission electron microscopy [AID372275, Type: Literature]
View
14
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as presence of one or two nucleus at 3 mM after 24 hrs by transmission electron microscopy [AID372276, Type: Literature]
View
15
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as increase in cisternal and vesicular structures within cytosol at 3 mM after 24 hrs by transmission electron microscopy [AID372277, Type: Literature]
View
16
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as increase in autophagic vaculoe structures at 3 mM after 24 hrs by transmission electron microscopy [AID372278, Type: Literature]
View
17
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as presence of myelin-like structures at 3 mM after 24 hrs by transmission electron microscopy [AID372279, Type: Literature]
View
18
[SID104246132]
Induction of programmed cell death in Trypanosoma brucei bloodstream form assessed as death of total cell population at > 4 nM up to 24 hrs using propidium iodide staining by FACS analysis [AID372319, Type: Literature]
View
19
[SID104246132]
Induction of necrosis in Trypanosoma brucei bloodstream form assessed as death of total cell population at > 4 nM up to 24 hrs using propidium iodide staining by FACS analysis [AID372320, Type: Literature]
View
20
[SID104246132]
Permeability across plasma membrane of Trypanosoma brucei bloodstream form expressing aquaglyceroporins using propidium iodide staining by FACS analysis [AID372321, Type: Literature]
View
21
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as appearance of multiple folds in mitochondrion membrane at 3 mM after 24 hrs by transmission electron microscopy [AID372459, Type: Literature]
View
22
[SID104246132]
IC50 1030Trypanocidal activity against Trypanosoma brucei bloodstream form assessed as phosphatase activity [AID372266, Type: Literature]
View
23
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as presence of more than one flagellum after 24 hrs using DAPI staining by phase-contrast microscopy [AID372267, Type: Literature]
View
24
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as increase in cell size after 24 hrs using DAPI staining by phase-contrast microscopy [AID372268, Type: Literature]
View
25
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as presence of atypical combination of number of nucleus after 24 hrs using DAPI staining by phase-contrast microscopy [AID372269, Type: Literature]
View
26
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as presence of kinetoplast after 24 hrs using DAPI staining by phase-contrast microscopy [AID372270, Type: Literature]
View
27
[SID104246132]
Compound was tested for inhibition of Human acrosin by ketoses [AID30431, Type: Literature]
View
28
[SID104246132]
Trypanocidal activity against Trypanosoma brucei bloodstream form assessed as decrease in cell density after 24 hrs by spectrophotometry [AID372263, Type: Literature]
View
29
[SID104246132]
Trypanocidal activity against Trypanosoma brucei bloodstream form at 4 mM up to 24 hrs by spectrophotometry [AID372264, Type: Literature]
View
30
[SID104246132]
Trypanocidal activity against Trypanosoma brucei bloodstream form at 5 mM up to 24 hrs by spectrophotometry [AID372265, Type: Literature]
View
31
[SID104246132]
Effect on cell cycle of Trypanosoma brucei bloodstream form assessed as induction of necrosis at 1 mM after 24 hrs using propidium iodide staining by FACS analysis [AID372287, Type: Literature]
View
32
[SID104246132]
Effect on cell cycle of Trypanosoma brucei bloodstream form assessed as induction of necrosis at 2 mM after 24 hrs using propidium iodide staining by FACS analysis [AID372288, Type: Literature]
View
33
[SID104246132]
Effect on cell cycle of Trypanosoma brucei bloodstream form assessed as induction of necrosis at 3 mM after 24 hrs using propidium iodide staining by FACS analysis [AID372289, Type: Literature]
View
34
[SID104246132]
Effect on cell cycle of Trypanosoma brucei bloodstream form assessed as induction of necrosis at 4 mM after 24 hrs using propidium iodide staining by FACS analysis [AID372290, Type: Literature]
View
35
[SID104246132]
Effect on cell cycle of Trypanosoma brucei bloodstream form assessed as induction of necrosis at 5 uM after 24 hrs using propidium iodide staining by FACS analysis [AID372291, Type: Literature]
View
36
[SID104246132]
Cell cycle arrest in Trypanosoma brucei bloodstream form assessed as accumulation at G2/M phase at 2 mM after 24 hrs using propidium iodide staining by FACS analysis [AID372292, Type: Literature]
View
37
[SID104246132]
Cell cycle arrest in Trypanosoma brucei bloodstream form assessed as accumulation at G2 phase at 2 mM after 24 hrs using propidium iodide staining by FACS analysis [AID372293, Type: Literature]
View
38
[SID104246132]
Effect on cell cycle of Trypanosoma brucei bloodstream form assessed as DNA content at 1 mM after 24 hrs using propidium iodide staining by FACS analysis [AID372294, Type: Literature]
View
39
[SID104246132]
Effect on cell cycle of Trypanosoma brucei bloodstream form assessed as DNA content at 2 mM after 24 hrs using propidium iodide staining by FACS analysis [AID372295, Type: Literature]
View
40
[SID104246132]
Effect on cell cycle of Trypanosoma brucei bloodstream form assessed as DNA content at 3 mM after 24 hrs using propidium iodide staining by FACS analysis [AID372296, Type: Literature]
View
41
[SID104246132]
Effect on cell cycle of Trypanosoma brucei bloodstream form assessed as DNA content at 4 mM after 24 hrs using propidium iodide staining by FACS analysis [AID372297, Type: Literature]
View
42
[SID104246132]
Effect on cell cycle of Trypanosoma brucei bloodstream form assessed as DNA content at 5 uM after 24 hrs using propidium iodide staining by FACS analysis [AID372298, Type: Literature]
View
43
[SID104246132]
Induction of apoptosis-like programmed cell death in Trypanosoma brucei bloodstream form assessed as loss of mitochondrial-membrane potential at 1 mM after 24 hrs by TMRE staining [AID372303, Type: Literature]
View
44
[SID104246132]
Induction of apoptosis-like programmed cell death in Trypanosoma brucei bloodstream form assessed as loss of mitochondrial-membrane potential at 2 mM after 24 hrs by TMRE staining [AID372304, Type: Literature]
View
45
[SID104246132]
Induction of apoptosis-like programmed cell death in Trypanosoma brucei bloodstream form assessed as loss of mitochondrial-membrane potential at 3 mM after 24 hrs by TMRE staining [AID372305, Type: Literature]
View
46
[SID104246132]
Induction of apoptosis-like programmed cell death in Trypanosoma brucei bloodstream form assessed as loss of mitochondrial-membrane potential at 4 mM after 24 hrs by TMRE staining [AID372306, Type: Literature]
View
47
[SID104246132]
Induction of apoptosis-like programmed cell death in Trypanosoma brucei bloodstream form assessed as loss of mitochondrial-membrane potential at 5 uM after 24 hrs by TMRE staining [AID372307, Type: Literature]
View
48
[SID104246132]
Induction of apoptosis-like programmed cell death in Trypanosoma brucei bloodstream form assessed as phosphatidylserine exposure in outer leaflet of plasma membrane at 1 mM after 24 hrs by V-Fluos staining staining [AID372309, Type: Literature]
View
49
[SID104246132]
Induction of apoptosis-like programmed cell death in Trypanosoma brucei bloodstream form assessed as phosphatidylserine exposure in outer leaflet of plasma membrane at 2 mM after 24 hrs by V-Fluos staining staining [AID372310, Type: Literature]
View
50
[SID104246132]
Induction of apoptosis-like programmed cell death in Trypanosoma brucei bloodstream form assessed as phosphatidylserine exposure in outer leaflet of plasma membrane at 3 mM after 24 hrs by V-Fluos staining staining [AID372311, Type: Literature]
View