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Dihydroxyacetone (CID 670) - Compound BioActivity Data
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BioActivity Outcomes:
Active(21)
 
 
Inactive(6)
 
 
Unspecified(36)
 
 
BioAssay Types:
Literature(63)
 
 
 
 
BioActivity Types:
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 63    Data Row: 63   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104246132]
Trypanocidal activity against Trypanosoma brucei bloodstream form assessed as cell death at 1 mM after 40 mins by spectrophotometry [AID372259, Type: Literature]
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2
[SID104246132]
Trypanocidal activity against Trypanosoma brucei bloodstream form at < 1 mM [AID372260, Type: Literature]
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3
[SID104246132]
Trypanocidal activity against Trypanosoma brucei bloodstream form at > 1 mM [AID372261, Type: Literature]
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4
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as presence of more than one flagellum at 5 mM after 20 hrs by scanning electron microscopy [AID372271, Type: Literature]
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5
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as increase in mitochondrion size at 3 mM after 24 hrs by transmission electron microscopy [AID372281, Type: Literature]
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6
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as dilation of mitochondrion membrane at 3 mM after 24 hrs by transmission electron microscopy [AID372282, Type: Literature]
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7
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as disorder of mitochondrion structure at 3 mM after 24 hrs by transmission electron microscopy [AID372283, Type: Literature]
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8
[SID104246132]
Effect on cell cycle of Trypanosoma brucei bloodstream form assessed as increase in cells with two nuclei and two kinetoplasts at 1 to 3 mM using DAPI staining by phase-contrast microscopy [AID372285, Type: Literature]
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9
[SID104246132]
Effect on cell cycle of Trypanosoma brucei bloodstream form assessed as increase in cells with two nuclei and one kinetoplast at 1 to 3 mM using DAPI staining by phase-contrast microscopy [AID372286, Type: Literature]
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10
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as dilation of mitochondrial membrane at 3 mM after 24 hrs by transmission electron microscopy [AID372299, Type: Literature]
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11
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as presence of glycosomes at 3 mM after 24 hrs by transmission electron microscopy [AID372300, Type: Literature]
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12
[SID104246132]
Trypanocidal activity against Trypanosoma brucei bloodstream form assessed as induction of autophagy at 3 mM after 24 hrs by transmission electron microscopy [AID372302, Type: Literature]
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13
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as presence of more than one flagellum at 3 mM after 24 hrs by transmission electron microscopy [AID372275, Type: Literature]
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14
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as presence of one or two nucleus at 3 mM after 24 hrs by transmission electron microscopy [AID372276, Type: Literature]
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15
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as increase in cisternal and vesicular structures within cytosol at 3 mM after 24 hrs by transmission electron microscopy [AID372277, Type: Literature]
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16
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as increase in autophagic vaculoe structures at 3 mM after 24 hrs by transmission electron microscopy [AID372278, Type: Literature]
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17
[SID104246132]
Effect on morphological changes in Trypanosoma brucei bloodstream form assessed as presence of myelin-like structures at 3 mM after 24 hrs by transmission electron microscopy [AID372279, Type: Literature]
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18
[SID104246132]
Induction of programmed cell death in Trypanosoma brucei bloodstream form assessed as death of total cell population at > 4 nM up to 24 hrs using propidium iodide staining by FACS analysis [AID372319, Type: Literature]
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19
[SID104246132]
Induction of necrosis in Trypanosoma brucei bloodstream form assessed as death of total cell population at > 4 nM up to 24 hrs using propidium iodide staining by FACS analysis [AID372320, Type: Literature]
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20
[SID104246132]
Permeability across plasma membrane of Trypanosoma brucei bloodstream form expressing aquaglyceroporins using propidium iodide staining by FACS analysis [AID372321, Type: Literature]
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