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3,3',4,5'-tetrahydroxystilbene (CID 667639) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(125)
 
 
Inactive(633)
 
 
Inconclusive(95)
 
 
Unspecified(53)
 
 
Top Targets:
7TM GPCR Srx(24)
 
 
 
7TM GPCR Srsx(16)
 
 
HELICc(9)
 
 
 
ANK(9)
 
 
 
 
PLDc mTdp1 2(8)
 
 
 
 
BioAssay Types:
Confirmatory(434)
 
 
 
 
 
Screening(349)
 
 
 
 
 
Literature(93)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(336)
 
 
 
 
 
IC50(42)
 
 
 
 
 
AC50(11)
 
 
 
EC50(7)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 729    Data Row: 906   Total Pages: 19   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID50106772]
Potency 0.3162qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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2
[SID56463614]
Potency 0.5623qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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3
[SID90341169]
Potency 0.5804HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators [AID488982, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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4
[SID56463614]
Potency 0.6513qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID90341169]
Potency 0.6702qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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6
[SID56463614]
AC50_uM 0.689HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity [AID493248, Type: confirmatory]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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7
[SID90341169]
Potency 0.8437qHTS Validation Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1) [AID488816, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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8
[SID90341169]
Potency 0.8437qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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9
[SID26753620]
Potency 1.4125qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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10
[SID26753620]
Potency 1.7783qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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11
[SID103264620]
IC50 1.8Antioxidant activity against cupric ion-induced lipid peroxidation in human LDL by TBA assay [AID401040, Type: Literature]
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12
[SID90341169]
Potency 1.9953qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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13
[SID29215167]
Potency 2.8184qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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14
[SID26753620]
Potency 2.8184qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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15
[SID103264620]
IC50 3Inhibition of PKA [AID378680, Type: Literature]
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16
[SID103264620]
IC50 3Inhibition of rat liver protein kinase A [AID325756, Type: Literature]
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17
[SID90341169]
Potency 3.6611Validation screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID493106, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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18
[SID90341169]
Potency 3.7933qHTS Validation Assay to Find Inhibitors of T. brucei phosphofructokinase [AID485368, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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19
[SID90341169]
Potency 4.1078qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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20
[SID29215167]
Potency 4.4668qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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21
[SID103264620]
IC50 5Inhibition of p56 Lck tyrosine kinase [AID224136, Type: Literature]
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22
[SID103264620]
EC50 5Inhibition of SYK in human basophils assessed as reduction in anti-IgE-stimulated histamine release [AID701085, Type: Literature]Lysine--tRNA ligase [gi:20178333]
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23
[SID26753619]
Potency 5.0119qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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24
[SID56463614]
Potency 5.1714qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504466, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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25
[SID56463614]
AC50_uM 5.21Luminescence assay for the detection of hydrogen peroxide activity in the abscence of ALR and DTT, at dose Measured in Biochemical System Using Plate Reader - 2036-03_Inhibitor_Dose_CherryPick_Activity [AID540356, Type: confirmatory]
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26
[SID29215167]
Potency 6.3096qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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27
[SID50106772]
Potency 7.0795qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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28
[SID56463614]
Potency 7.0795qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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29
[SID56463614]
AC50_uM 7.534MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity [AID588345, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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30
[SID56463614]
Potency 7.9433qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator precursor [Mus musculus] [gi:6679377]
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31
[SID56463614]
Potency 7.9433qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase plasminogen activator surface receptor precursor [Mus musculus] [gi:7242179]
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32
[SID50106772]
Potency 7.9433qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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33
[SID26753620]
Potency 7.9433Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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34
[SID56463614]
Potency 7.9433qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]plasminogen precursor [Mus musculus] [gi:257471003]
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35
[SID103264620]
IC50 8Binding affinity at PKC [AID325586, Type: Literature]
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36
[SID103264620]
IC50 8Inhibition of PKC [AID378673, Type: Literature]
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37
[SID56463614]
Potency 8.4921qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase [AID485367, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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38
[SID26753619]
Potency 8.9125Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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39
[SID50106772]
Potency 8.9125qHTS for differential inhibitors of proliferation of Plasmodium falciparum line GB4 [AID1816, Type: confirmatory]
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40
[SID26753619]
Potency 9.2qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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41
[SID56463614]
Potency 9.5283qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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42
[SID103264620]
IC50 10Inhibition of p72 Syk [AID325757, Type: Literature]
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43
[SID50106772]
Potency 10qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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44
[SID50106772]
Potency 10qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
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45
[SID103264620]
IC50 10Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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46
[SID103264620]
IC50 10Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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47
[SID103264620]
IC50 10Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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48
[SID26753619]
Potency 10.3225qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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49
[SID56463614]
Potency 11.2202qHTS of Trypanosoma Brucei Inhibitors: Confirmatory Assay for Cherry-picked Compounds [AID720569, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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50
[SID50106772]
Potency 11.2202Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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